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Macrolide antibiotic. Inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram-positive and gram-negative organisms. Orally active with improved pharmacokinetics over erythromycin in mouse models. Inhibits autophagy.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 748.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.34 mL||6.68 mL||13.35 mL|
|5 mM||0.27 mL||1.34 mL||2.67 mL|
|10 mM||0.13 mL||0.67 mL||1.34 mL|
|50 mM||0.03 mL||0.13 mL||0.27 mL|
References are publications that support the biological activity of the product.
Retsema et al (1987) Spectrum and mode of action of azithro. (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms. Antimicrob.Agents Chemother. 31 1939 PMID: 2449865
Girard et al (1987) Pharmacokinetic and in vivo studies with azithro. (CP-62,993), a new macrolide with extended half-life and excellent tissue distribution. Antimicrob.Agents Chemother. 31 1948 PMID: 2830841
Champney and Burdine (1995) Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtilis and Staphylococcus aureas. Antimicrob.Agents Chemother. 39 2141 PMID: 8540733
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316
If you know of a relevant reference for Azithromycin, please let us know.
Keywords: Azithromycin, Azithromycin supplier, Macrolides, antibiotics, Inhibits, inhibitors, 50S, ribosomal, subunit, formation, elongation, transpeptidation, gram, positive, negative, CP62993, Pfizer, CP, 62993, DNA,, RNA, and, Protein, Synthesis, Antibiotics, Autophagy, 3771, Tocris Bioscience
3 Citations for Azithromycin
Citations are publications that use Tocris products. Selected citations for Azithromycin include:
Broad and Sanger (2013) The antibiotic azithro. is a motilin receptor agonist in human stomach: comparison with erythro. Br J Pharmacol 168 1859 PMID: 23190027
Palmer et al (2018) Nonoptimal Gene Expression Creates Latent Potential for Antibiotic Resistance. Mol Biol Evol 35 2669 PMID: 30169679
Groote et al (2018) Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent. Front Microbiol 9 2231 PMID: 30294313
Do you know of a great paper that uses Azithromycin from Tocris? Please let us know.
Reviews for Azithromycin
Average Rating: 5 (Based on 1 Review.)
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Literature in this Area
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