Macrolide antibiotic. Inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram-positive and gram-negative organisms. Orally active with improved pharmacokinetics over erythromycin in mouse models. Inhibits autophagy.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 748.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.34 mL||6.68 mL||13.35 mL|
|5 mM||0.27 mL||1.34 mL||2.67 mL|
|10 mM||0.13 mL||0.67 mL||1.34 mL|
|50 mM||0.03 mL||0.13 mL||0.27 mL|
References are publications that support the biological activity of the product.
Retsema et al (1987) Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms. Antimicrob.Agents Chemother. 31 1939 PMID: 2449865
Girard et al (1987) Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with extended half-life and excellent tissue distribution. Antimicrob.Agents Chemother. 31 1948 PMID: 2830841
Champney and Burdine (1995) Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtilis and Staphylococcus aureas. Antimicrob.Agents Chemother. 39 2141 PMID: 8540733
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316
If you know of a relevant reference for Azithromycin, please let us know.
Keywords: Azithromycin, Azithromycin supplier, Macrolides, antibiotics, Inhibits, inhibitors, 50S, ribosomal, subunit, formation, elongation, transpeptidation, gram, positive, negative, CP62993, Pfizer, CP, 62993, DNA,, RNA, and, Protein, Synthesis, Antibiotics, Autophagy, 3771, Tocris Bioscience
1 Citation for Azithromycin
Citations are publications that use Tocris products. Selected citations for Azithromycin include:
Broad and Sanger (2013) The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin. Br J Pharmacol 168 1859 PMID: 23190027
Do you know of a great paper that uses Azithromycin from Tocris? Please let us know.
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Literature in this Area
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