Irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).
(Modifications: Val-1 = N-terminal H-iso-Valeryl, Val-2 = Val-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-4-amino-3-hydroxy-6-methylheptanoic-acid)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in ethanol with gentle warming|
References are publications that support the biological activity of the product.
Marciniszyn et al (1976) Mode of inhibition of acid proteases by pepstatin. J.Biol.Chem. 251 7088 PMID: 993206
Merck Index 12 7290
Sato et al (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67 9677 PMID: 17942897
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Keywords: Pepstatin A, Pepstatin A supplier, Aspartic, protease, inhibitors, inhibits, Proteases, Proteinases, PepstatinA, Other, Autophagy, 1190, Tocris Bioscience
1 Citation for Pepstatin A
Citations are publications that use Tocris products. Selected citations for Pepstatin A include:
Tsai et al (2013) WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma. J Neurosci 4 e792 PMID: 24008736
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