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Biological Activity for Pepstatin A
Pepstatin A is an irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).
Technical Data for Pepstatin A
(Modifications: Val-1 = N-terminal H-iso-Valeryl, Val-2 = Val-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-4-amino-3-hydroxy-6-methylheptanoic-acid)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pepstatin A
|Solubility||Soluble to 1 mg/ml in ethanol with gentle warming|
References for Pepstatin A
References are publications that support the biological activity of the product.
Marciniszyn et al (1976) Mode of inhibition of acid proteases by pepstatin. J.Biol.Chem. 251 7088 PMID: 993206
Sato et al (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67 9677 PMID: 17942897
Gacko et al (2007) Cathepsin D inhibitors. Folia Histochem.Cytobiol. 45 291 PMID: 18165168
Mizuochi et al (1997) Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain. Immunol.Lett. 43 189 PMID: 7721331
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Keywords: Pepstatin A, Pepstatin A supplier, Aspartic, protease, inhibitors, inhibits, Proteases, Proteinases, PepstatinA, cathepsin, D, selective, high, affinity, Autophagy, Cathepsin, 1190, Tocris Bioscience
3 Citations for Pepstatin A
Citations are publications that use Tocris products. Selected citations for Pepstatin A include:
Berg et al (2019) Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation. Cell Rep 27 2837 PMID: 31167131
Guerroue et al (2017) Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell 68 786 PMID: 29149599
Tsai et al (2013) WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma. J Neurosci 4 e792 PMID: 24008736
Do you know of a great paper that uses Pepstatin A from Tocris? Please let us know.
Reviews for Pepstatin A
Average Rating: 4 (Based on 1 Review.)
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use this as a protease inhibitor in my protein isolation buffer. It was a beneficial product for the Rat profiling cytokine assay kit.