Pepstatin A

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Cat.No. 1190 - Pepstatin A | H-iso-Valeryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic-acid | CAS No. 26305-03-3
Description: Selective and high affinity cathepsin D inhibitor
Datasheet
Citations (3)
Reviews (1)

Biological Activity for Pepstatin A

Pepstatin A is an irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).

Technical Data for Pepstatin A

M. Wt 685.91
Formula C34H63N5O9
Sequence VVA

(Modifications: Val-1 = N-terminal H-iso-Valeryl, Val-2 = Val-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-4-amino-3-hydroxy-6-methylheptanoic-acid)

Storage Desiccate at -20°C
CAS Number 26305-03-3
PubChem ID 5478883
InChI Key FAXGPCHRFPCXOO-LXTPJMTPSA-N
Smiles O=C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@H]([C@@H](O)CC(O)=O)CC(C)C)=O)=O)[C@H]([C@@H](C)C)NC([C@@H](NC(CC(C)C)=O)C(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Pepstatin A

Solubility Soluble to 1 mg/ml in ethanol with gentle warming

Product Datasheets for Pepstatin A

Certificate of Analysis / Product Datasheet
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References for Pepstatin A

References are publications that support the biological activity of the product.

Marciniszyn et al (1976) Mode of inhibition of acid proteases by pepstatin. J.Biol.Chem. 251 7088 PMID: 993206

Sato et al (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67 9677 PMID: 17942897

Gacko et al (2007) Cathepsin D inhibitors. Folia Histochem.Cytobiol. 45 291 PMID: 18165168

Mizuochi et al (1997) Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain. Immunol.Lett. 43 189 PMID: 7721331


If you know of a relevant reference for Pepstatin A, please let us know.

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Keywords: Pepstatin A, Pepstatin A supplier, Aspartic, protease, inhibitors, inhibits, Proteases, Proteinases, PepstatinA, cathepsin, D, selective, high, affinity, Autophagy, Cathepsin, 1190, Tocris Bioscience

3 Citations for Pepstatin A

Citations are publications that use Tocris products. Selected citations for Pepstatin A include:

Berg et al (2019) Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation. Cell Rep 27 2837 PMID: 31167131

Guerroue et al (2017) Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell 68 786 PMID: 29149599

Tsai et al (2013) WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma. J Neurosci 4 e792 PMID: 24008736


Do you know of a great paper that uses Pepstatin A from Tocris? Please let us know.

Reviews for Pepstatin A

Average Rating: 4 (Based on 1 Review.)

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Protease Inhibitor.
By Anonymous on 03/08/2021
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Vessels

use this as a protease inhibitor in my protein isolation buffer. It was a beneficial product for the Rat profiling cytokine assay kit.