Pepstatin A

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Cat.No. 1190 - Pepstatin A | H-iso-Valeryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic-acid | CAS No. 26305-03-3
Description: Aspartic protease inhibitor
Datasheet
Citations (3)
Reviews
Literature (1)

Biological Activity

Irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).

Technical Data

M. Wt 685.91
Formula C34H63N5O9
Sequence VVA

(Modifications: Val-1 = N-terminal H-iso-Valeryl, Val-2 = Val-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-4-amino-3-hydroxy-6-methylheptanoic-acid)

Storage Desiccate at -20°C
CAS Number 26305-03-3
PubChem ID 5478883
InChI Key FAXGPCHRFPCXOO-LXTPJMTPSA-N
Smiles O=C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@H]([C@@H](O)CC(O)=O)CC(C)C)=O)=O)[C@H]([C@@H](C)C)NC([C@@H](NC(CC(C)C)=O)C(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in ethanol with gentle warming

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Marciniszyn et al (1976) Mode of inhibition of acid proteases by pepstatin. J.Biol.Chem. 251 7088 PMID: 993206

Merck Index 12 7290

Sato et al (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67 9677 PMID: 17942897


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Keywords: Pepstatin A, Pepstatin A supplier, Aspartic, protease, inhibitors, inhibits, Proteases, Proteinases, PepstatinA, Other, Autophagy, 1190, Tocris Bioscience

3 Citations for Pepstatin A

Citations are publications that use Tocris products. Selected citations for Pepstatin A include:

Berg et al (2019) Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation. Cell Rep 27 2837 PMID: 31167131

Tsai et al (2013) WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma. J Neurosci 4 e792 PMID: 24008736

Guerroue et al (2017) Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell 68 786 PMID: 29149599


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Literature in this Area

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