Irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).
(Modifications: Val-1 = N-terminal H-iso-Valeryl, Val-2 = Val-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-4-amino-3-hydroxy-6-methylheptanoic-acid)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in ethanol with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 685.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.46 mL||7.29 mL||14.58 mL|
|5 mM||0.29 mL||1.46 mL||2.92 mL|
|10 mM||0.15 mL||0.73 mL||1.46 mL|
|50 mM||0.03 mL||0.15 mL||0.29 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Marciniszyn et al (1976) Mode of inhibition of acid proteases by pepstatin. J.Biol.Chem. 251 7088 PMID: 993206
Sato et al (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67 9677 PMID: 17942897
If you know of a relevant reference for Pepstatin A, please let us know.
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Keywords: Pepstatin A, supplier, Aspartic, protease, inhibitors, inhibits, Proteases, Proteinases, PepstatinA, Other, Proteases, Tocris Bioscience
1 Citation for Pepstatin A
Citations are publications that use Tocris products. Selected citations for Pepstatin A include:
Tsai et al (2013) WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma. J Neurosci 4 e792 PMID: 24008736
Do you know of a great paper that uses Pepstatin A from Tocris? If so please let us know.
Literature in this Area
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