Pepstatin A

Pricing Availability Delivery Time Qty
Cat.No. 1190 - Pepstatin A | H-iso-Valeryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic-acid | CAS No. 26305-03-3
Description: Aspartic protease inhibitor
Datasheet
Citations (1)
Literature

Biological Activity

Irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).

Technical Data

M. Wt 685.89
Formula C34H63N5O9
Sequence VVA

(Modifications: Val-1 = N-terminal H-iso-Valeryl, Val-2 = Val-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-4-amino-3-hydroxy-6-methylheptanoic-acid)

Storage Desiccate at -20°C
CAS Number 26305-03-3
PubChem ID 5478883
InChI Key FAXGPCHRFPCXOO-LXTPJMTPSA-N
Smiles O=C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@H]([C@@H](O)CC(O)=O)CC(C)C)=O)=O)[C@H]([C@@H](C)C)NC([C@@H](NC(CC(C)C)=O)C(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in ethanol with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 685.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.46 mL 7.29 mL 14.58 mL
5 mM 0.29 mL 1.46 mL 2.92 mL
10 mM 0.15 mL 0.73 mL 1.46 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Marciniszyn et al (1976) Mode of inhibition of acid proteases by pepstatin. J.Biol.Chem. 251 7088 PMID: 993206

Merck Index 12 7290 PMID:

Sato et al (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67 9677 PMID: 17942897


If you know of a relevant reference for Pepstatin A, please let us know.

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Keywords: Pepstatin A, supplier, Aspartic, protease, inhibitors, inhibits, Proteases, Proteinases, PepstatinA, Other, Proteases, Autophagy, Other, Proteases, Tocris Bioscience

1 Citation for Pepstatin A

Citations are publications that use Tocris products. Selected citations for Pepstatin A include:

Tsai et al (2013) WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma. J Neurosci 4 e792 PMID: 24008736


Do you know of a great paper that uses Pepstatin A from Tocris? If so please let us know.

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