3-Methyladenine

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Cat.No. 3977 - 3-Methyladenine | C6H7N5 | CAS No. 5142-23-4
Description: Class III PI 3-kinase inhibitor; also inhibits autophagy
Alternative Names: 3-MA
Chemical Name: 3-Methyl-3H-purin-6-amine
Purity: ≥99% (HPLC)
Datasheet
Citations (8)
Reviews
Literature (4)

Biological Activity

Inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation.

Compound Libraries

3-Methyladenine is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 149.15
Formula C6H7N5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 5142-23-4
PubChem ID 1673
InChI Key FSASIHFSFGAIJM-UHFFFAOYSA-N
Smiles NC(N=CN2C)=C1C2=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.98 20

Preparing Stock Solutions

The following data is based on the product molecular weight 149.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 33.52 mL 167.62 mL 335.23 mL
1 mM 6.7 mL 33.52 mL 67.05 mL
2 mM 3.35 mL 16.76 mL 33.52 mL
10 mM 0.67 mL 3.35 mL 6.7 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Blommaart et al (1997) The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur.J.Biochem. 243 240 PMID: 9030745

Canu et al (2005) Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. J.Neurochem. 92 1228 PMID: 15715672

Seglen and Gordon (1982) 3-methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc.Natl.Acad.Sci. USA 79 1889


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View Related Products by Product Action

View all PI 3-kinase Inhibitors

Keywords: 3-Methyladenine, 3-Methyladenine supplier, pi, 3-kinase, phosphatidylinositol, 3, kinase, inhibitors, inhibits, autophagy, 3-MA, pi3k, PI, 3-Kinase, Inositol, Lipids, Other, Apoptosis, Autophagy, 3977, Tocris Bioscience

8 Citations for 3-Methyladenine

Citations are publications that use Tocris products. Selected citations for 3-Methyladenine include:

Park et al (2019) Gliotoxin Enhances Autophagic Cell Death via the DAPK1-TAp63 Signaling Pathway in PTX-Resistant Ovarian Cancer Cells. Mar Drugs 17 PMID: 31336860

Vidakovics et al (2019) Junín virus induces autophagy in human A549 cells. PLoS One 14 e0218730 PMID: 31216340

Wang et al (2013) Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Nat Commun 2013 857929 PMID: 23762164

Wolf et al (2013) Miz1 is required to maintain autophagic flux. Clin Transl Med 4 2535 PMID: 24088869


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Literature in this Area

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