Inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 149.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.7 mL||33.52 mL||67.05 mL|
|5 mM||1.34 mL||6.7 mL||13.41 mL|
|10 mM||0.67 mL||3.35 mL||6.7 mL|
|50 mM||0.13 mL||0.67 mL||1.34 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Blommaart et al (1997) The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur.J.Biochem. 243 240 PMID: 9030745
Canu et al (2005) Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. J.Neurochem. 92 1228 PMID: 15715672
If you know of a relevant reference for 3-Methyladenine, please let us know.
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Keywords: 3-Methyladenine, supplier, pi, 3-kinase, phosphatidylinositol, 3, kinase, inhibitors, inhibits, autophagy, 3-MA, pi3k, 3-MA, PI, 3-Kinase, Inositol, Lipids, Other, Apoptosis, Autophagy, PI, 3-Kinase, Tocris Bioscience
4 Citations for 3-Methyladenine
Citations are publications that use Tocris products. Selected citations for 3-Methyladenine include:
Nepal et al (2015) Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis. Evid Based Complement Alternat Med 6 7166 PMID: 25704884
Kim et al (2013) Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation. J Biol Chem 288 22693 PMID: 23754277
Wang et al (2013) Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Nat Commun 2013 857929 PMID: 23762164
Wolf et al (2013) Miz1 is required to maintain autophagic flux. Clin Transl Med 4 2535 PMID: 24088869
Do you know of a great paper that uses 3-Methyladenine from Tocris? If so please let us know.