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Inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 149.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||33.52 mL||167.62 mL||335.23 mL|
|1 mM||6.7 mL||33.52 mL||67.05 mL|
|2 mM||3.35 mL||16.76 mL||33.52 mL|
|10 mM||0.67 mL||3.35 mL||6.7 mL|
References are publications that support the biological activity of the product.
Blommaart et al (1997) The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur.J.Biochem. 243 240 PMID: 9030745
Canu et al (2005) Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. J.Neurochem. 92 1228 PMID: 15715672
Seglen and Gordon (1982) 3-methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc.Natl.Acad.Sci. USA 79 1889
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Keywords: 3-Methyladenine, 3-Methyladenine supplier, pi, 3-kinase, phosphatidylinositol, 3, kinase, inhibitors, inhibits, autophagy, 3-MA, pi3k, PI, 3-Kinase, Inositol, Lipids, Other, Apoptosis, Autophagy, 3977, Tocris Bioscience
8 Citations for 3-Methyladenine
Citations are publications that use Tocris products. Selected citations for 3-Methyladenine include:
Park et al (2019) Gliotoxin Enhances Autophagic Cell Death via the DAPK1-TAp63 Signaling Pathway in PTX-Resistant Ovarian Cancer Cells. Mar Drugs 17 PMID: 31336860
Vidakovics et al (2019) Junín virus induces autophagy in human A549 cells. PLoS One 14 e0218730 PMID: 31216340
Wang et al (2013) Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Nat Commun 2013 857929 PMID: 23762164
Wolf et al (2013) Miz1 is required to maintain autophagic flux. Clin Transl Med 4 2535 PMID: 24088869
Sagrillo-Fagundes et al (2019) Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells. PLoS One 14 e0202458 PMID: 30629581
Nepal et al (2015) Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis. Evid Based Complement Alternat Med 6 7166 PMID: 25704884
Kim et al (2013) Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation. J Biol Chem 288 22693 PMID: 23754277
Hylin et al (2018) A role for autophagy in long-term spatial memory formation in male rodents. J Neurosci Res 96 416 PMID: 29230855
Do you know of a great paper that uses 3-Methyladenine from Tocris? Please let us know.
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