You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
MRT 68601 hydrochloride
Potent TBK1 (TANK-binding kinase-1) inhibitor (IC50 = 6 nM). Inhibits the formation of autophagosomes in lung cancer cells.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 487.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.05 mL||10.27 mL||20.53 mL|
|5 mM||0.41 mL||2.05 mL||4.11 mL|
|10 mM||0.21 mL||1.03 mL||2.05 mL|
|50 mM||0.04 mL||0.21 mL||0.41 mL|
References are publications that support the biological activity of the product.
Newman et al (2012) TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. PLoS ONE 7 e50672 PMID: 23209807
McIver et al (2012) Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKe kinases. Bioorg.Med.Chem.Lett. 22 7169 PMID: 23099093
If you know of a relevant reference for MRT 68601 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: MRT 68601 hydrochloride, MRT 68601 hydrochloride supplier, MRT68601, hydrochloride, potent, TBK1, TANK-binding, kinase-1, inhibitors, inhibits, autophagy, autophagosomes, Autophagy, TANK, binding, kinase, (TBK), 5067, Tocris Bioscience
Citations for MRT 68601 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for MRT 68601 hydrochloride. Do you know of a great paper that uses MRT 68601 hydrochloride from Tocris? Please let us know.
Reviews for MRT 68601 hydrochloride
There are currently no reviews for this product. Be the first to review MRT 68601 hydrochloride and earn rewards!
Have you used MRT 68601 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.