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MRT 68601 hydrochloride
Biological Activity for MRT 68601 hydrochloride
MRT 68601 hydrochloride is a potent TBK1 (TANK-binding kinase-1) inhibitor (IC50 = 6 nM). Inhibits the formation of autophagosomes in lung cancer cells.
Technical Data for MRT 68601 hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MRT 68601 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for MRT 68601 hydrochloride
The following data is based on the product molecular weight 487.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.05 mL||10.27 mL||20.53 mL|
|5 mM||0.41 mL||2.05 mL||4.11 mL|
|10 mM||0.21 mL||1.03 mL||2.05 mL|
|50 mM||0.04 mL||0.21 mL||0.41 mL|
Product Datasheets for MRT 68601 hydrochloride
References for MRT 68601 hydrochloride
References are publications that support the biological activity of the product.
Newman et al (2012) TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. PLoS ONE 7 e50672 PMID: 23209807
McIver et al (2012) Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKe kinases. Bioorg.Med.Chem.Lett. 22 7169 PMID: 23099093
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Citations for MRT 68601 hydrochloride
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Literature in this Area
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