You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Spautin 1
Spautin 1 is an inhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.
Compound Libraries for Spautin 1
Technical Data for Spautin 1
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Spautin 1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Spautin 1
The following data is based on the product molecular weight 271.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.69 mL||18.43 mL||36.87 mL|
|5 mM||0.74 mL||3.69 mL||7.37 mL|
|10 mM||0.37 mL||1.84 mL||3.69 mL|
|50 mM||0.07 mL||0.37 mL||0.74 mL|
References for Spautin 1
References are publications that support the biological activity of the product.
Salabei et al (2013) PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. Biochem.J. 451 375 PMID: 23421427
Liu et al (2011) Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147 223 PMID: 21962518
If you know of a relevant reference for Spautin 1, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Spautin 1, Spautin 1 supplier, class, III, PI3, kinase, autophagy, inhibitors, inhibits, USP10, USP13, deubiquitinating, enzymes, vps34, Deubiquitinating, Enzymes, Autophagy, 5197, Tocris Bioscience
Citations for Spautin 1
Citations are publications that use Tocris products.
Currently there are no citations for Spautin 1. Do you know of a great paper that uses Spautin 1 from Tocris? Please let us know.
Reviews for Spautin 1
There are currently no reviews for this product. Be the first to review Spautin 1 and earn rewards!
Have you used Spautin 1?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image