Spautin 1

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Cat.No. 5197 - Spautin 1 | C15H11F2N3 | CAS No. 1262888-28-7
Description: USP10 and USP13 inhibitor; inhibits autophagy
Chemical Name: 6-Fluoro-N-[(4-Fluorophenyl)methyl]-4-quinazolinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Inhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.

Compound Libraries

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Technical Data

M. Wt 271.26
Formula C15H11F2N3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1262888-28-7
PubChem ID 51037431
InChI Key AWIVHRPYFSSVOG-UHFFFAOYSA-N
Smiles FC1=CC=C(N=CN=C2NCC3=CC=C(F)C=C3)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 271.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.69 mL 18.43 mL 36.87 mL
5 mM 0.74 mL 3.69 mL 7.37 mL
10 mM 0.37 mL 1.84 mL 3.69 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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References

References are publications that support the biological activity of the product.

Salabei et al (2013) PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. Biochem.J. 451 375 PMID: 23421427

Liu et al (2011) Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147 223 PMID: 21962518


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Keywords: Spautin 1, Spautin 1 supplier, class, III, PI3, kinase, autophagy, inhibitors, inhibits, USP10, USP13, deubiquitinating, enzymes, vps34, Deubiquitinating, Enzymes, Autophagy, 5197, Tocris Bioscience

Citations for Spautin 1

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