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Cat.No. 4686 - Xanthohumol | C21H22O5 | CAS No. 6754-58-1
Description: p97 ATPase (VCP) inhibitor
Chemical Name: (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

p97 ATPase (VCP) inhibitor. Binds to the N domain of p97, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC50 = 50.3 μM).

Technical Data

M. Wt 354.4
Formula C21H22O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 6754-58-1
PubChem ID 639665
Smiles OC1=C(C(/C=C/C2=CC=C(O)C=C2)=O)C(OC)=CC(O)=C1C/C=C(C)/C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.44 100
ethanol 35.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 354.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.22 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Sasazawa et al (2012) Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein. ACS Chem.Biol. 7 892 PMID: 22360440

Tabata et al (1997) Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry 46 683 PMID: 9366096

Inokoshi et al (2009) Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. J.Antibiot.(Tokyo) 62 51 PMID: 19132064

If you know of a relevant reference for Xanthohumol, please let us know.

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Keywords: Xanthohumol, supplier, valosin-containing, protein, VCP, transitional, endoplasmic, reticulum, ATPase, TER, inhibitors, autophagosome, autophagy, apoptosis, inhibits, p97, ATPase, Tocris Bioscience

1 Citation for Xanthohumol

Citations are publications that use Tocris products. Selected citations for Xanthohumol include:

den Brok et al (2016) Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation Nature Communications 7 13324 PMID: 27819292

Do you know of a great paper that uses Xanthohumol from Tocris? If so please let us know.

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Literature in this Area


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Cancer Metabolism Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.

Pathways for Xanthohumol


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