Xanthohumol

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Cat.No. 4686 - Xanthohumol | C21H22O5 | CAS No. 6754-58-1
Description: p97 ATPase (VCP) inhibitor
Chemical Name: (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)

Biological Activity

p97 ATPase (VCP) inhibitor. Binds to the N domain of p97, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC50 = 50.3 μM).

Technical Data

M. Wt 354.4
Formula C21H22O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 6754-58-1
PubChem ID 639665
InChI Key ORXQGKIUCDPEAJ-YRNVUSSQSA-N
Smiles OC1=C(C(/C=C/C2=CC=C(O)C=C2)=O)C(OC)=CC(O)=C1C/C=C(C)/C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.44 100
ethanol 35.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 354.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.22 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Sasazawa et al (2012) Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein. ACS Chem.Biol. 7 892 PMID: 22360440

Tabata et al (1997) Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry 46 683 PMID: 9366096

Inokoshi et al (2009) Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. J.Antibiot.(Tokyo) 62 51 PMID: 19132064


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View Related Products by Product Action

View all p97 ATPase Inhibitors

Keywords: Xanthohumol, Xanthohumol supplier, valosin-containing, protein, VCP, transitional, endoplasmic, reticulum, ATPase, TER, inhibitors, autophagosome, autophagy, apoptosis, inhibits, Autophagy, Diacylglycerol, O-Acyltransferase, Other, ER, stress/UPR, p97, 4686, Tocris Bioscience

1 Citation for Xanthohumol

Citations are publications that use Tocris products. Selected citations for Xanthohumol include:

den Brok et al (2016) Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation Nature Communications 7 13324 PMID: 27819292


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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