Antimalarial drug. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine (Cat. No. 3977).
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 515.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.94 mL||9.69 mL||19.39 mL|
|5 mM||0.39 mL||1.94 mL||3.88 mL|
|10 mM||0.19 mL||0.97 mL||1.94 mL|
|50 mM||0.04 mL||0.19 mL||0.39 mL|
References are publications that support the products' biological activity.
Jiang et al (2010) Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. Biomed.Pharmacother. 64 609 PMID: 20888174
Sasaki et al (2010) Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. BMC Cancer 10 370 PMID: 20630104
If you know of a relevant reference for Chloroquine diphosphate, please let us know.
Keywords: Chloroquine diphosphate, supplier, Chloroquine, diphosphate, antimalarial, antitumor, antimetastatic, autophagy, apoptosis, Other, Apoptosis, Autophagy, Other, Apoptosis, Tocris Bioscience
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.