Chloroquine diphosphate

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Cat.No. 4109 - Chloroquine diphosphate | C18H26ClN3·2H3PO4 | CAS No. 50-63-5
Description: Antimalarial; inhibits apoptosis and autophagy
Chemical Name: N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity

Antimalarial drug. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine (Cat. No. 3977).

Technical Data

M. Wt 515.86
Formula C18H26ClN3·2H3PO4
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 50-63-5
PubChem ID 64927
InChI Key QKICWELGRMTQCR-UHFFFAOYSA-N
Smiles CCN(CC)CCCC(C)NC2=CC=NC1=CC(Cl)=CC=C12.O=P(O)(O)O.O=P(O)(O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 51.59 100

Preparing Stock Solutions

The following data is based on the product molecular weight 515.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.69 mL 19.39 mL
5 mM 0.39 mL 1.94 mL 3.88 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Jiang et al (2010) Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. Biomed.Pharmacother. 64 609 PMID: 20888174

Sasaki et al (2010) Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. BMC Cancer 10 370 PMID: 20630104


If you know of a relevant reference for Chloroquine diphosphate, please let us know.

Keywords: Chloroquine diphosphate, Chloroquine diphosphate supplier, Chloroquine, diphosphate, antimalarial, antitumor, antimetastatic, autophagy, apoptosis, Other, Apoptosis, Autophagy, Antimalarials, 4109, Tocris Bioscience

2 Citations for Chloroquine diphosphate

Citations are publications that use Tocris products. Selected citations for Chloroquine diphosphate include:

Tong et al (2018) Corilagin inhibits breast cancer growth via reactive oxygen species-dependent apoptosis and autophagy. J Cell Mol Med PMID: 29923307

Gupta et al (2014) Opioid receptor function is regulated by post-endocytic peptide processing. J Biol Chem 289 19613 PMID: 24847082


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Literature in this Area

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