HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.
Deuterated analog also available.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 418.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.39 mL||11.95 mL||23.89 mL|
|5 mM||0.48 mL||2.39 mL||4.78 mL|
|10 mM||0.24 mL||1.19 mL||2.39 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the products' biological activity.
Garrett et al (2001) Statins and bone formation. Curr.Pharm.Des. 7 715 PMID: 11405194
Kaushal et al (2003) Potential anticancer effects of statins: fact or fiction? Endothelium 10 49 PMID: 12699077
White (1999) Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation. J.Clin.Pharmacol. 39 111 PMID: 11563401
Reinoso et al (2002) Preclinical pharmacokinetics of statins. Methods Find.Exp.Clin.Pharmacol. 24 593 PMID: 12616706
If you know of a relevant reference for Simvastatin, please let us know.
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Keywords: Simvastatin, supplier, HMG-CoA, reductase, inhibitors, inhibits, Reductases, ferroptosis, hyperlipidemia, hypolipemic, HMG-CoA, Reductase, Ferroptosis, HMG-CoA, Reductase, Tocris Bioscience
3 Citations for Simvastatin
Citations are publications that use Tocris products. Selected citations for Simvastatin include:
Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. Br J Pharmacol 8 e66404 PMID: 23799098
Vainio et al (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. Pharmacol Res Perspect 2 1176 PMID: 22202492
Seto et al (2007) Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells. Oncotarget 151 987 PMID: 17558433
Do you know of a great paper that uses Simvastatin from Tocris? If so please let us know.
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