Simvastatin

Pricing Availability Delivery Time Qty
Cat.No. 1965 - Simvastatin | C25H38O5 | CAS No. 79902-63-9
Description: HMG-CoA reductase inhibitor
Chemical Name: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews (1)
Literature

Biological Activity

HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Deuterated analog also available.

Compound Libraries

Simvastatin is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 418.57
Formula C25H38O5
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 79902-63-9
PubChem ID 54454
InChI Key RYMZZMVNJRMUDD-HGQWONQESA-N
Smiles [H][C@@]12C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(O3)=O)=C[C@H](C)C[C@@H]1OC(C(C)(C)CC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 31.39 75
DMSO 20.93 50

Preparing Stock Solutions

The following data is based on the product molecular weight 418.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.95 mL 23.89 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
10 mM 0.24 mL 1.19 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Garrett et al (2001) Statins and bone formation. Curr.Pharm.Des. 7 715 PMID: 11405194

Kaushal et al (2003) Potential anticancer effects of statins: fact or fiction? Endothelium 10 49 PMID: 12699077

White (1999) Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation. J.Clin.Pharmacol. 39 111 PMID: 11563401

Reinoso et al (2002) Preclinical pharmacokinetics of statins. Methods Find.Exp.Clin.Pharmacol. 24 593 PMID: 12616706


If you know of a relevant reference for Simvastatin, please let us know.

View Related Products by Product Action

View all HMG-CoA Reductase Inhibitors

Keywords: Simvastatin, Simvastatin supplier, HMG-CoA, reductase, inhibitors, inhibits, Reductases, ferroptosis, hyperlipidemia, hypolipemic, statins, Reductase, Ferroptosis, 1965, Tocris Bioscience

4 Citations for Simvastatin

Citations are publications that use Tocris products. Selected citations for Simvastatin include:

Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. Br J Pharmacol 8 e66404 PMID: 23799098

Vainio et al (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. Pharmacol Res Perspect 2 1176 PMID: 22202492

Seto et al (2007) Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells. Oncotarget 151 987 PMID: 17558433

Rojo-Arreola et al (2014) Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One 9 e87594 PMID: 24489942


Do you know of a great paper that uses Simvastatin from Tocris? Please let us know.

Reviews for Simvastatin

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Role of mevalonate pathway inhibitor for protection of joint degeneration
By Anonymous on 03/22/2018
Assay Type: In Vitro
Species: Other
Cell Line/Tissue: cartilage

I used this drug to test the role of mevalonate pathway in joint integrity

It works well and the price is nice.


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