Concanamycin A

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Cat.No. 2656 - Concanamycin A | C46H75NO14 | CAS No. 80890-47-7
Description: H+-ATPase (vacuolar) inhibitor
Alternative Names: Folimycin
Chemical Name: (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one
Purity: ≥90% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Specific inhibitor of V-type (vacuolar) H+-ATPase that displays > 2000-fold selectivity over other H+-ATPases (IC50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H+-ATPases and porcine P-type Na+,K+-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.

Technical Data

M. Wt 866.09
Formula C46H75NO14
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 80890-47-7
PubChem ID 6438151
InChI Key DJZCTUVALDDONK-HQMSUKCRSA-N
Smiles O=C1O[C@@]([C@@H](C)[C@@H](O)[C@H](C)[C@]2(O)O[C@H](/C=C/C)[C@@H](C)[C@H](O[C@]3([H])O[C@H](C)[C@@H](OC(N)=O)[C@H](O)C3)C2)([H])[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)[C@H](O)[C@H](C)/C=C(C)/C=C1\OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble in DMSO

References

References are publications that support the biological activity of the product.

Hong et al (2006) Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells. J.Pharmacol.Exp.Ther. 319 672 PMID: 16895977

Muroi et al (1993) Folimycin (Concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitus virus before arrival to the golgi apparatus. Cell Struct.Function. 18 139

Nishihara et al (1995) Specific inhibitors of vacuolar type H+-ATPases induce apoptotic cell death. Biochem.Biophy.Res.Comm. 212 255


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Keywords: Concanamycin A, Concanamycin A supplier, H+-ATPase, vacuolar, inhibitors, inhibits, V-Type, Hydrogen-ATPases, Ion, Transporters, Pumps, ConcanamycinA, antibiotics, Folimycin, Antibiotics, Autophagy, 2656, Tocris Bioscience

1 Citation for Concanamycin A

Citations are publications that use Tocris products. Selected citations for Concanamycin A include:

Chabaud et al (2015) Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells. Nat Commun 6 7526 PMID: 26109323


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Literature in this Area

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