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Biological Activity for Concanamycin A
Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that displays > 2000-fold selectivity over other H+-ATPases (IC50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H+-ATPases and porcine P-type Na+,K+-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.
Technical Data for Concanamycin A
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Concanamycin A
|Solubility||Soluble in DMSO|
References for Concanamycin A
References are publications that support the biological activity of the product.
Hong et al (2006) Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells. J.Pharmacol.Exp.Ther. 319 672 PMID: 16895977
Muroi et al (1993) Folimycin (Concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitus virus before arrival to the golgi apparatus. Cell Struct.Function. 18 139
Nishihara et al (1995) Specific inhibitors of vacuolar type H+-ATPases induce apoptotic cell death. Biochem.Biophy.Res.Comm. 212 255
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Keywords: Concanamycin A, Concanamycin A supplier, H+-ATPase, vacuolar, inhibitors, inhibits, V-Type, Hydrogen-ATPases, Ion, Transporters, Pumps, ConcanamycinA, antibiotics, Folimycin, Antibiotics, Autophagy, 2656, Tocris Bioscience
2 Citations for Concanamycin A
Citations are publications that use Tocris products. Selected citations for Concanamycin A include:
Gomes-da-Silva et al (2019) Recruitment of LC3 to damaged Golgi apparatus. Cell Death Differ 26 1467 PMID: 30349077
Chabaud et al (2015) Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells. Nat Commun 6 7526 PMID: 26109323
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