Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMRT 68921 dihydrochloride is a potent ULK inhibitor (IC50 values are 1.1 and 2.9 nM for ULK2 and ULK1, respectively). Inhibits autophagy in mouse embryonic fibroblasts.
M. Wt | 507.5 |
Formula | C25H34N6O.2HCl |
Storage | Desiccate at RT |
Purity | ≥98% (HPLC) |
PubChem ID | 124201611 |
InChI Key | NLKPLTWKINJHCK-UHFFFAOYSA-N |
Smiles | CN1CCC2=CC(NC3=NC=C(C(NCCCNC(C4CCC4)=O)=N3)C5CC5)=CC=C2C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 50.75 | 100 |
The following data is based on the product molecular weight 507.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.97 mL | 9.85 mL | 19.7 mL |
5 mM | 0.39 mL | 1.97 mL | 3.94 mL |
10 mM | 0.2 mL | 0.99 mL | 1.97 mL |
50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
References are publications that support the biological activity of the product.
Petherick et al (2015) Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J.Biol.Chem. 290 11376 PMID: 25833948
If you know of a relevant reference for MRT 68921 dihydrochloride, please let us know.
Keywords: MRT 68921 dihydrochloride, MRT 68921 dihydrochloride supplier, MRT68921, dihydrochloride, ULK1, 2, inhibitors, inhibits, autophagy, potent, Other, Kinases, Autophagy, 5780, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for MRT 68921 dihydrochloride. Do you know of a great paper that uses MRT 68921 dihydrochloride from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review MRT 68921 dihydrochloride and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image