MRT 68921 dihydrochloride

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Description: ULK inhibitor
Chemical Name: N-[3-[[5-Cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews

Biological Activity for MRT 68921 dihydrochloride

MRT 68921 dihydrochloride is a potent ULK inhibitor (IC50 values are 1.1 and 2.9 nM for ULK2 and ULK1, respectively). Inhibits autophagy in mouse embryonic fibroblasts.

Technical Data for MRT 68921 dihydrochloride

M. Wt 507.5
Formula C25H34N6O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 2080306-21-2
PubChem ID 124201611
InChI Key NLKPLTWKINJHCK-UHFFFAOYSA-N
Smiles CN1CCC2=CC(NC3=NC=C(C(NCCCNC(C4CCC4)=O)=N3)C5CC5)=CC=C2C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MRT 68921 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 50.75 100

Preparing Stock Solutions for MRT 68921 dihydrochloride

The following data is based on the product molecular weight 507.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.85 mL 19.7 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets for MRT 68921 dihydrochloride

References for MRT 68921 dihydrochloride

References are publications that support the biological activity of the product.

Petherick et al (2015) Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J.Biol.Chem. 290 11376 PMID: 25833948


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Keywords: MRT 68921 dihydrochloride, MRT 68921 dihydrochloride supplier, MRT68921, dihydrochloride, ULK1, 2, inhibitors, inhibits, autophagy, potent, Other, Kinases, Autophagy, 5780, Tocris Bioscience

6 Citations for MRT 68921 dihydrochloride

Citations are publications that use Tocris products. Selected citations for MRT 68921 dihydrochloride include:

Pia et al (2021) Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells. Cells 10 PMID: 33673037

Jesse C et al (2021) Endoplasmic reticulum tubules limit the size of misfolded protein condensates. Elife 10 PMID: 34467852

Elena et al (2020) The mito-QC Reporter for Quantitative Mitophagy Assessment in Primary Retinal Ganglion Cells and Experimental Glaucoma Models. Int J Mol Sci 21 PMID: 32164182

Wei et al (2020) Podocytes maintain high basal levels of autophagy independent of mtor signaling. Autophagy 16 1932-1948 PMID: 31865844


Do you know of a great paper that uses MRT 68921 dihydrochloride from Tocris? Please let us know.

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