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Submit ReviewMRT 68921 dihydrochloride
Description: ULK inhibitor
Chemical Name: N-[3-[[5-Cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for MRT 68921 dihydrochloride
MRT 68921 dihydrochloride is a potent ULK inhibitor (IC50 values are 1.1 and 2.9 nM for ULK2 and ULK1, respectively). Inhibits autophagy in mouse embryonic fibroblasts.
Technical Data for MRT 68921 dihydrochloride
| M. Wt | 507.5 |
| Formula | C25H34N6O.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 2080306-21-2 |
| PubChem ID | 124201611 |
| InChI Key | NLKPLTWKINJHCK-UHFFFAOYSA-N |
| Smiles | CN1CCC2=CC(NC3=NC=C(C(NCCCNC(C4CCC4)=O)=N3)C5CC5)=CC=C2C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MRT 68921 dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 50.75 | 100 |
Preparing Stock Solutions for MRT 68921 dihydrochloride
The following data is based on the product molecular weight 507.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.97 mL | 9.85 mL | 19.7 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.94 mL |
| 10 mM | 0.2 mL | 0.99 mL | 1.97 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
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Product Datasheets for MRT 68921 dihydrochloride
References for MRT 68921 dihydrochloride
References are publications that support the biological activity of the product.
Petherick et al (2015) Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J.Biol.Chem. 290 11376 PMID: 25833948
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Keywords: MRT 68921 dihydrochloride, MRT 68921 dihydrochloride supplier, MRT68921, dihydrochloride, ULK1, 2, inhibitors, inhibits, autophagy, potent, Other, Kinases, Autophagy, 5780, Tocris Bioscience
6 Citations for MRT 68921 dihydrochloride
Citations are publications that use Tocris products. Selected citations for MRT 68921 dihydrochloride include:
Pia et al (2021) Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells. Cells 10 PMID: 33673037
Jesse C et al (2021) Endoplasmic reticulum tubules limit the size of misfolded protein condensates. Elife 10 PMID: 34467852
Patricia et al (2022) Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration. Nat Commun 13 4220 PMID: 35864098
Andreas et al (2023) Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity. Transl Psychiatry 13 143 PMID: 37137886
Elena et al (2020) The mito-QC Reporter for Quantitative Mitophagy Assessment in Primary Retinal Ganglion Cells and Experimental Glaucoma Models. Int J Mol Sci 21 PMID: 32164182
Wei et al (2020) Podocytes maintain high basal levels of autophagy independent of mtor signaling. Autophagy 16 1932-1948 PMID: 31865844
Do you know of a great paper that uses MRT 68921 dihydrochloride from Tocris? Please let us know.
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