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MRT 68921 dihydrochloride

Cat. No. 5780 Submit a Review Datasheet / COA / SDS
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Cat.No. 5780 - MRT 68921 dihydrochloride | C25H34N6O.2HCl
Description: PGK1 inhibitior
Chemical Name: N-[3-[[5-Cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MRT 68921 dihydrochloride

MRT 68921 dihydrochloride is a potent ULK inhibitor (IC50 values are 1.1 and 2.9 nM for ULK2 and ULK1, respectively). Inhibits autophagy in mouse embryonic fibroblasts.

Technical Data for MRT 68921 dihydrochloride

M. Wt 507.5
Formula C25H34N6O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 124201611
InChI Key NLKPLTWKINJHCK-UHFFFAOYSA-N
Smiles CN1CCC2=CC(NC3=NC=C(C(NCCCNC(C4CCC4)=O)=N3)C5CC5)=CC=C2C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MRT 68921 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 50.75 100

Preparing Stock Solutions for MRT 68921 dihydrochloride

The following data is based on the product molecular weight 507.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.85 mL 19.7 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets for MRT 68921 dihydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for MRT 68921 dihydrochloride

References are publications that support the biological activity of the product.

Petherick et al (2015) Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J.Biol.Chem. 290 11376 PMID: 25833948

If you know of a relevant reference for MRT 68921 dihydrochloride, please let us know.

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Keywords: MRT 68921 dihydrochloride, MRT 68921 dihydrochloride supplier, MRT68921, dihydrochloride, ULK1, 2, inhibitors, inhibits, autophagy, potent, Other, Kinases, Autophagy, 5780, Tocris Bioscience

Citations for MRT 68921 dihydrochloride

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