MRT 68921 dihydrochloride

Pricing Availability   Qty
Description: ULK inhibitor
Chemical Name: N-[3-[[5-Cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride
Purity: ≥98% (HPLC)
Citations (6)
Literature (1)

Biological Activity for MRT 68921 dihydrochloride

MRT 68921 dihydrochloride is a potent ULK inhibitor (IC50 values are 1.1 and 2.9 nM for ULK2 and ULK1, respectively). Inhibits autophagy in mouse embryonic fibroblasts.

Technical Data for MRT 68921 dihydrochloride

M. Wt 507.5
Formula C25H34N6O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 2080306-21-2
PubChem ID 124201611
Smiles CN1CCC2=CC(NC3=NC=C(C(NCCCNC(C4CCC4)=O)=N3)C5CC5)=CC=C2C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MRT 68921 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 50.75 100

Preparing Stock Solutions for MRT 68921 dihydrochloride

The following data is based on the product molecular weight 507.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.85 mL 19.7 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets for MRT 68921 dihydrochloride

References for MRT 68921 dihydrochloride

References are publications that support the biological activity of the product.

Petherick et al (2015) Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J.Biol.Chem. 290 11376 PMID: 25833948

If you know of a relevant reference for MRT 68921 dihydrochloride, please let us know.

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Keywords: MRT 68921 dihydrochloride, MRT 68921 dihydrochloride supplier, MRT68921, dihydrochloride, ULK1, 2, inhibitors, inhibits, autophagy, potent, Other, Kinases, Autophagy, 5780, Tocris Bioscience

6 Citations for MRT 68921 dihydrochloride

Citations are publications that use Tocris products. Selected citations for MRT 68921 dihydrochloride include:

Pia et al (2021) Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells. Cells 10 PMID: 33673037

Jesse C et al (2021) Endoplasmic reticulum tubules limit the size of misfolded protein condensates. Elife 10 PMID: 34467852

Patricia et al (2022) Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration. Nat Commun 13 4220 PMID: 35864098

Andreas et al (2023) Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity. Transl Psychiatry 13 143 PMID: 37137886

Do you know of a great paper that uses MRT 68921 dihydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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