Hydroxychloroquine sulfate

Pricing Availability Delivery Time Qty
Cat.No. 5648 - Hydroxychloroquine sulfate | C18H28ClN3O5S | CAS No. 747-36-4
Description: Autophagy inhibitor; also TLR9 inhibitor
Chemical Name: 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol sulfate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Autophagy inhibitor. Inhibits growth and induces apoptosis of renal cancer cells in vitro. Also inhibits TLR9.

Technical Data

M. Wt 433.95
Formula C18H28ClN3O5S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 747-36-4
PubChem ID 12947
InChI Key JCBIVZZPXRZKTI-UHFFFAOYSA-N
Smiles ClC(C=C1)=CC2=C1C(NC(CCCN(CC)CCO)C)=CC=N2.OS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 43.4 100

Preparing Stock Solutions

The following data is based on the product molecular weight 433.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.52 mL 23.04 mL
5 mM 0.46 mL 2.3 mL 4.61 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lee et al (2015) Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. PLoS ONE 10 e0131464 PMID: 26134285

Lamphier et al (2014) Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol.Pharmacol. 85 429 PMID: 24342772


If you know of a relevant reference for Hydroxychloroquine sulfate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Autophagy Inhibitors

Keywords: TLR9 toll-like receptors inhibitors autophagy inhibits cancer Autophagy

Citations for Hydroxychloroquine sulfate

Citations are publications that use Tocris products.

Currently there are no citations for Hydroxychloroquine sulfate. Do you know of a great paper that uses Hydroxychloroquine sulfate from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Autophagy

Autophagy Scientific Review

Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

Autophagy

Autophagy Poster

Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Hydroxychloroquine sulfate

Protocols

TODO: Add Protocols