Hydroxychloroquine sulfate

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Cat.No. 5648 - Hydroxychloroquine sulfate | C18H28ClN3O5S | CAS No. 747-36-4
Description: Autophagy inhibitor; also TLR9 inhibitor
Chemical Name: 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol sulfate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Autophagy inhibitor. Inhibits growth and induces apoptosis of renal cancer cells in vitro. Also inhibits TLR9.

Technical Data

M. Wt 433.95
Formula C18H28ClN3O5S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 747-36-4
PubChem ID 12947
InChI Key JCBIVZZPXRZKTI-UHFFFAOYSA-N
Smiles ClC(C=C1)=CC2=C1C(NC(CCCN(CC)CCO)C)=CC=N2.OS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 43.4 100

Preparing Stock Solutions

The following data is based on the product molecular weight 433.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.52 mL 23.04 mL
5 mM 0.46 mL 2.3 mL 4.61 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lee et al (2015) Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. PLoS ONE 10 e0131464 PMID: 26134285

Lamphier et al (2014) Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol.Pharmacol. 85 429 PMID: 24342772


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Keywords: Hydroxychloroquine sulfate, supplier, TLR9, toll-like, receptors, inhibitors, autophagy, inhibits, cancer, Toll-like, Receptors, Autophagy, Autophagy, Tocris Bioscience

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Autophagy

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