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Biological Activity for Hydroxychloroquine sulfate
Hydroxychloroquine sulfate is an autophagy inhibitor. Also inhibits TLR9. Inhibits growth and induces apoptosis of renal cancer cells in vitro. Additionally inhibits PRC2 by inhibiting the allosteric binding of PRC2 to EED (embryonic ectoderm development) within the H3K27me3-binding pocket, and reduces H3K27me3 levels in multiple myeloma cells in vitro. Inhibits SARS-CoV-2 viral infection, in vitro (EC50 values in μM range and dependent on viral RNA copy number). Also antimalarial and immunomodulator.
Tocris products are for biomedical research use only. They are not intended for human or veterinary use.
Technical Data for Hydroxychloroquine sulfate
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Hydroxychloroquine sulfate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Hydroxychloroquine sulfate
The following data is based on the product molecular weight 433.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.3 mL||11.52 mL||23.04 mL|
|5 mM||0.46 mL||2.3 mL||4.61 mL|
|10 mM||0.23 mL||1.15 mL||2.3 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
Product Datasheets for Hydroxychloroquine sulfate
References for Hydroxychloroquine sulfate
References are publications that support the biological activity of the product.
Lee et al (2015) Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. PLoS ONE 10 e0131464 PMID: 26134285
Lamphier et al (2014) Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol.Pharmacol. 85 429 PMID: 24342772
Catalano et al (2019) A drug repurposing screening reveals a novel epigenetic activity of hydroxychloroquine. Eur.J.Med.Chem. 183 PMID: 31550663
Liu et al (2020) Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discovery 6 16 PMID: 32194981
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Keywords: Hydroxychloroquine sulfate, Hydroxychloroquine sulfate supplier, TLR9, toll-like, receptors, inhibitors, autophagy, inhibits, cancer, immunomodulator, antimalarial, Toll-like, Receptors, Autophagy, Other, Lysine, Methyltransferases, COVID-19, Endocytosis, Antimalarials, Coronavirus, 5648, Tocris Bioscience
Citations for Hydroxychloroquine sulfate
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Literature in this Area
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