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Products (22)
Targets (5)
Resources (3)

"apoptosis" has 22 results in Products.

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Apoptosis Activator 2

Cat. No. 2098/10
Description: Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
Purity: ≥99% (HPLC)
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Streptozocin

Cat. No. 1621/100
Description: DNA alkylator; antitumor and induces diabetes
Purity: ≥95% (HPLC)
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Temozolomide

Cat. No. 2706/10
Description: DNA-methylating antitumor agent
Purity: ≥98% (HPLC)
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Oxaliplatin

Cat. No. 2623/50
Description: DNA cross-linking antitumor agent
Purity: ≥99% (HPLC)
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Carboplatin

Cat. No. 2626/50
Description: DNA cross-linking antitumor agent
Purity: ≥99% (HPLC)
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Mitomycin C

Cat. No. 3258/2
Description: DNA cross-linking antitumor agent
Purity: ≥98% (HPLC)
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Kaempferol

Cat. No. 3603/50
Description: Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
Purity: ≥98% (HPLC)
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Betulinic acid

Cat. No. 3906/10
Description: Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
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FK 866

Cat. No. 8072/10
Description: Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
Purity: ≥98% (HPLC)
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AT 101

Cat. No. 3367/10
Description: Downregulates Bcl-2 and Mcl-1; pro-apoptotic
Purity: ≥98% (HPLC)
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Cyclophosphamide

Cat. No. 4091/50
Description: Alkylating agent; chemotherapeutic
Purity: ≥99% (HPLC)
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SMBA 1

Cat. No. 5314/10
Description: High affinity and selective activator of Bax
Purity: ≥98% (HPLC)
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C 75

Cat. No. 2489/10
Description: Potent fatty acid synthase inhibitor; proapoptotic
Purity: ≥94% (HPLC)
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Fludarabine

Cat. No. 3495/10
Description: Purine analog; inhibits DNA synthesis
Purity: ≥98% (HPLC)
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Actinomycin D

Cat. No. 1229/10
Description: Inhibits RNA polymerase
Purity: ≥95% (HPLC)
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Cisplatin

Cat. No. 2251/50
Description: Potent pro-apoptotic anticancer agent; activates caspase-3
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LYN 1604 dihydrochloride

Cat. No. 6617/10
Description: Potent UNC-51-like kinase 1 (ULK1) agonist
Purity: ≥98% (HPLC)
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Evofosfamide

Cat. No. 7507/10
Description: Hypoxia-activated DNA alkylating agent prodrug
Purity: ≥98% (HPLC)
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Bz 423

Cat. No. 5791/10
Description: ATP synthase inhibitor; proapoptotic
Purity: ≥98% (HPLC)
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Narciclasine

Cat. No. 3715/1
Description: Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression
Purity: ≥98% (HPLC)
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Doxorubicin hydrochloride

Cat. No. 2252/10
Description: Antitumor antibiotic agent. Inhibits DNA topoisomerase II
Purity: ≥98% (HPLC)
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PCI 34051

Cat. No. 4643/10
Description: Potent and selective HDAC8 inhibitor
Purity: ≥98% (HPLC)
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"apoptosis" has 5 results in Targets.

ASK1

Apoptosis signal-regulated kinase 1 (ASK1) is a serine/threonine kinase, MAP3K family member, which induces apoptosis through the activation of JNK and p38. ASK1 has been implicated in the pathology of neurodegenerative and oxidative stress-related diseases.

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Apoptosis

Apoptosis is a mechanism of cell death that occurs after sufficient cellular damage. It occurs normally during development and aging and is considered a vital component of cell turnover, cell development and function of the immune system. It occurs as a defense mechanism such as in immune reactions or when cells are damaged by disease or noxious agents.

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Apoptosis Inducers

Apoptosis inducers exhibit pro-apoptotic effects through a variety of mechanisms, including DNA cross-linking, inhibition of antiapoptotic proteins and activation of caspases. These inducers may target a specific cellular process in order to induce antitumor or antineoplastic effects.

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Inhibitor of Apoptosis

The inhibitor of apoptosis (IAP) family of proteins are major regulators of apoptosis through interaction with components of the apoptotic signaling cascades. Discovered in baculovirus, human homologs can be described as baculovirus IAP repeat containing (BIRC) proteins.

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"apoptosis" has 3 results in Resources.

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

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Huntington's Disease Life Science Poster

Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.

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Programmed Cell Death Life Science Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

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