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Exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC50 = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro. Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 307.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.25 mL||16.27 mL||32.55 mL|
|5 mM||0.65 mL||3.25 mL||6.51 mL|
|10 mM||0.33 mL||1.63 mL||3.25 mL|
|50 mM||0.07 mL||0.33 mL||0.65 mL|
References are publications that support the biological activity of the product.
Dumont et al (2007) The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts. Neoplasia 9 766 PMID: 17898872
Ingrassia et al (2009) Structure-activity relationship analysis of novel derivatives of narciclasine (an Amaryllidaceae isocarbostyril derivative) as potential anticancer agents. J.Med.Chem. 52 1100 PMID: 19199649
Lefranc et al (2009) Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells. Mol.Cancer Ther. 8 1739 PMID: 19531573
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Keywords: Narciclasine, Narciclasine supplier, Narciclasine, small, g, proteins, rhoA, rho, kinases, ROCK, signaling, signalling, modulators, anticancer, antiproliferative, agents, cell, cycle, inhibitors, inhibits, actin, Cell, Cycle, Inhibitors, Actin, Apoptosis, Inducers, Rho, 3715, Tocris Bioscience
1 Citation for Narciclasine
Citations are publications that use Tocris products. Selected citations for Narciclasine include:
Duman et al (2019) The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest. Elife 8 PMID: 31461398
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Literature in this Area
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