Streptozocin

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Cat.No. 1621 - Streptozocin | C8H15N3O7 | CAS No. 18883-66-4
Description: DNA alkylator; antitumor and induces diabetes
Alternative Names: Streptozotocin
Chemical Name: 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)

Biological Activity

Antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cells in vivo.

Technical Data

M. Wt 265.22
Formula C8H15N3O7
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 18883-66-4
PubChem ID 2733335
InChI Key ZSJLQEPLLKMAKR-YDEIVXIUSA-N
Smiles O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(N(C)N=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.52 100
DMSO 26.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 265.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.85 mL 37.7 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.89 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Bennett and Pegg (1981) Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 41 2786 PMID: 6454479

Weis (1982) Steptozotocin: A review of its pharmacology, efficacy and toxicity. Cancer Treat. Rep. 66 427 PMID: 6277485


If you know of a relevant reference for Streptozocin, please let us know.

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Keywords: Streptozocin, Streptozocin supplier, DNA, alkylators, antitumor, antitmour, induces, diabetes, Apoptosis, Inducers, antibiotics, chemotherapeutics, Streptozotocin, Antibiotics, 1621, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Streptozocin (streptozotocin), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Streptozocin

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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Streptozocin

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.