Streptozocin

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Cat.No. 1621 - Streptozocin | C8H15N3O7 | CAS No. 18883-66-4
Description: DNA alkylator; antitumor and induces diabetes
Alternative Names: Streptozotocin
Chemical Name: 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cells in vivo.

Technical Data

M. Wt 265.22
Formula C8H15N3O7
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 18883-66-4
PubChem ID 2733335
InChI Key ZSJLQEPLLKMAKR-YDEIVXIUSA-N
Smiles O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(N(C)N=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.52 100
water 26.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 265.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.85 mL 37.7 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.89 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bennett and Pegg (1981) Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 41 2786 PMID: 6454479

Weis (1982) Steptozotocin: A review of its pharmacology, efficacy and toxicity. Cancer Treat. Rep. 66 427 PMID: 6277485


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Keywords: Streptozocin, supplier, DNA, alkylators, antitumor, antitmour, induces, diabetes, Apoptosis, Inducers, antibiotics, chemotherapeutics, Streptozotocin, Apoptosis, Inducers, Antibiotics, Apoptosis, Inducers, Tocris Bioscience

Citations for Streptozocin

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Pathways for Streptozocin

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.