Bz 423
Biological Activity
ATP synthase inhibitor (IC50 ~5 μM). Binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase in vitro resulting in generation of superoxide and apoptosis. Kills primary B and T cell in mice in vivo. Suppresses autoimmunity and prolongs survival in mouse lupus model.
Technical Data
| M. Wt | 440.92 |
| Formula | C27H21ClN2O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 216691-95-1 |
| PubChem ID | 5497206 |
| InChI Key | IJEUIRDNQUQMFU-UHFFFAOYSA-N |
| Smiles | CN1C2=CC=C(C=C2C(C3=CC=C(C=C3)O)=NC(C1=O)CC4=CC5=CC=CC=C5C=C4)Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.09 | 100 | |
| ethanol | 44.09 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 440.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.34 mL | 22.68 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Johnson et al (2005) Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423. Chem.Biol. 12 485 PMID: 15850986
Blatt et al (2009) Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochem.Pharmacol. 15 966 PMID: 19481066
Blatt et al (2002) Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. J.Clin.Invest. 110 1123 PMID: 12393848
If you know of a relevant reference for Bz 423, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Bz 423, supplier, Bz423, ATP, synthase, inhibitors, inhibits, pro-apoptotic, oligomycin, sensitivity, conferring, protein, OSCP, autoimmunity, superoxide, generation, Other, Synthases/Synthetases, Apoptosis, Inducers, Other, Synthases/Synthetases, Tocris Bioscience
Citations for Bz 423
Citations are publications that use Tocris products.
Currently there are no citations for Bz 423. Do you know of a great paper that uses Bz 423 from Tocris? If so please let us know.
Reviews for Bz 423
There are currently no reviews for this product. Be the first to review Bz 423 and earn rewards!
Have you used Bz 423?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and Europe
Submit a ReviewLiterature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
