Bz 423

Pricing Availability   Qty
Description: ATP synthase inhibitor; proapoptotic
Chemical Name: 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for Bz 423

Bz 423 is an ATP synthase inhibitor (IC50 ~5 μM). Binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase in vitro resulting in generation of superoxide and apoptosis. Kills primary B and T cell in mice in vivo. Suppresses autoimmunity and prolongs survival in mouse lupus model.

Technical Data for Bz 423

M. Wt 440.92
Formula C27H21ClN2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 216691-95-1
PubChem ID 5497206
Smiles CN1C2=CC=C(C=C2C(C3=CC=C(C=C3)O)=NC(C1=O)CC4=CC5=CC=CC=C5C=C4)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bz 423

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 44.09 100
ethanol 44.09 100

Preparing Stock Solutions for Bz 423

The following data is based on the product molecular weight 440.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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References for Bz 423

References are publications that support the biological activity of the product.

Johnson et al (2005) Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423. Chem.Biol. 12 485 PMID: 15850986

Blatt et al (2009) Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochem.Pharmacol. 15 966 PMID: 19481066

Blatt et al (2002) Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. J.Clin.Invest. 110 1123 PMID: 12393848

If you know of a relevant reference for Bz 423, please let us know.

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Keywords: Bz 423, Bz 423 supplier, Bz423, ATP, synthase, inhibitors, inhibits, pro-apoptotic, oligomycin, sensitivity, conferring, protein, OSCP, autoimmunity, superoxide, generation, Other, Synthases/Synthetases, Apoptosis, Inducers, 5791, Tocris Bioscience

1 Citation for Bz 423

Citations are publications that use Tocris products. Selected citations for Bz 423 include:

Giorgia et al (2020) Impaired flickering of the permeability transition pore causes SPG7 spastic paraplegia. EBioMedicine 61 103050 PMID: 33045469

Do you know of a great paper that uses Bz 423 from Tocris? Please let us know.

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