Home / Pharmacology / Enzymes / Synthases/Synthetases / Other Synthases/Synthetases / Other Synthase/Synthetase Inhibitors / Bz 423

Bz 423

Cat. No. 5791 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 5791 - Bz 423 | C27H21ClN2O2 | CAS No. 216691-95-1
Description: ATP synthase inhibitor; proapoptotic
Chemical Name: 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Bz 423

Bz 423 is an ATP synthase inhibitor (IC50 ~5 μM). Binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase in vitro resulting in generation of superoxide and apoptosis. Kills primary B and T cell in mice in vivo. Suppresses autoimmunity and prolongs survival in mouse lupus model.

Compound Libraries for Bz 423

Bz 423 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Bz 423

M. Wt 440.92
Formula C27H21ClN2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 216691-95-1
PubChem ID 5497206
InChI Key IJEUIRDNQUQMFU-UHFFFAOYSA-N
Smiles CN1C2=CC=C(C=C2C(C3=CC=C(C=C3)O)=NC(C1=O)CC4=CC5=CC=CC=C5C=C4)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bz 423

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.09 100
ethanol 44.09 100

Preparing Stock Solutions for Bz 423

The following data is based on the product molecular weight 440.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Bz 423

References are publications that support the biological activity of the product.

Johnson et al (2005) Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423. Chem.Biol. 12 485 PMID: 15850986

Blatt et al (2009) Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochem.Pharmacol. 15 966 PMID: 19481066

Blatt et al (2002) Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. J.Clin.Invest. 110 1123 PMID: 12393848

If you know of a relevant reference for Bz 423, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Synthase/Synthetase Inhibitors

Keywords: Bz 423, Bz 423 supplier, Bz423, ATP, synthase, inhibitors, inhibits, pro-apoptotic, oligomycin, sensitivity, conferring, protein, OSCP, autoimmunity, superoxide, generation, Other, Synthases/Synthetases, Apoptosis, Inducers, 5791, Tocris Bioscience

Citations for Bz 423

Citations are publications that use Tocris products.

Currently there are no citations for Bz 423. Do you know of a great paper that uses Bz 423 from Tocris? Please let us know.

Reviews for Bz 423

There are currently no reviews for this product. Be the first to review Bz 423 and earn rewards!

Have you used Bz 423?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis