Bz 423

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Cat.No. 5791 - Bz 423 | C27H21ClN2O2 | CAS No. 216691-95-1
Description: ATP synthase inhibitor; proapoptotic
Chemical Name: 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

ATP synthase inhibitor (IC50 ~5 μM). Binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase in vitro resulting in generation of superoxide and apoptosis. Kills primary B and T cell in mice in vivo. Suppresses autoimmunity and prolongs survival in mouse lupus model.

Technical Data

M. Wt 440.92
Formula C27H21ClN2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 216691-95-1
PubChem ID 5497206
InChI Key IJEUIRDNQUQMFU-UHFFFAOYSA-N
Smiles CN1C2=CC=C(C=C2C(C3=CC=C(C=C3)O)=NC(C1=O)CC4=CC5=CC=CC=C5C=C4)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.09 100
ethanol 44.09 100

Preparing Stock Solutions

The following data is based on the product molecular weight 440.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Johnson et al (2005) Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423. Chem.Biol. 12 485 PMID: 15850986

Blatt et al (2009) Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochem.Pharmacol. 15 966 PMID: 19481066

Blatt et al (2002) Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. J.Clin.Invest. 110 1123 PMID: 2393848


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Keywords: Bz423 ATP synthase inhibitors inhibits pro-apoptotic oligomycin sensitivity conferring protein OSCP autoimmunity superoxide generation Other Synthases/Synthetases

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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