Apoptosis Activator 2

Pricing Availability Delivery Time Qty
Cat.No. 2098 - Apoptosis Activator 2 | C15H9Cl2NO2 | CAS No. 79183-19-0
Description: Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
Chemical Name: 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM).

Compound Libraries

Apoptosis Activator 2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 306.14
Formula C15H9Cl2NO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 79183-19-0
PubChem ID 1901244
InChI Key KGRJPLRFGLMQMV-UHFFFAOYSA-N
Smiles ClC1=CC=C(CN2C(=O)C(=O)C3=CC=CC=C23)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.61 100
ethanol 1.53 5

Preparing Stock Solutions

The following data is based on the product molecular weight 306.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.27 mL 16.33 mL 32.66 mL
5 mM 0.65 mL 3.27 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.27 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Alavian et al (2009) Elevtaed p75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev. 4 11 PMID: 19291307

Jayaraman and Pike (2009) Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones. J.Neuroendocrinol. 21 77 PMID: 19094096

Nguyen and Wells (2003) Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc.Natl.Acad.Sci.USA 100 7533 PMID:


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1 Citation for Apoptosis Activator 2

Citations are publications that use Tocris products. Selected citations for Apoptosis Activator 2 include:

Stankiewicz et al (2005) Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation. PLoS One 280 38729 PMID: 16172114


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