AT 101

Pricing Availability   Qty
Description: Downregulates Bcl-2 and Mcl-1; pro-apoptotic
Chemical Name: (-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Pathways (1)

Biological Activity for AT 101

AT 101 is a R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.

Compound Libraries for AT 101

AT 101 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AT 101

M. Wt 518.56
Formula C30H30O8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 90141-22-3
PubChem ID 3503
InChI Key QBKSWRVVCFFDOT-UHFFFAOYSA-N
Smiles OC1=[C@]([C@]2=C(O)C(C(C=O)=C(O)C(O)=C3C(C)C)=C3C=C2C)C(C)=CC4=C1C(C=O)=C(O)C(O)=C4C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AT 101

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.37 20

Preparing Stock Solutions for AT 101

The following data is based on the product molecular weight 518.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.64 mL 48.21 mL 96.42 mL
1 mM 1.93 mL 9.64 mL 19.28 mL
2 mM 0.96 mL 4.82 mL 9.64 mL
10 mM 0.19 mL 0.96 mL 1.93 mL

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Product Datasheets for AT 101

Certificate of Analysis / Product Datasheet
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References for AT 101

References are publications that support the biological activity of the product.

Balakrishnan et al (2009) AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood 113 149 PMID: 18836097

Kline et al (2008) R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells. Exp.Hematol. 36 568 PMID: 18346839

Loberg et al (2007) In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. Neoplasia 9 1030 PMID: 18084610


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View Related Products by Target

Keywords: AT 101, AT 101 supplier, downregulates, Bcl-2, Mcl-1, proapoptotic, apoptosis, inducer, gossypol, Bcl, AT101, Family, Apoptosis, Inducers, 3367, Tocris Bioscience

1 Citation for AT 101

Citations are publications that use Tocris products. Selected citations for AT 101 include:

Chen et al (2016) Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells. World J Gastroenterol 11 e0156145 PMID: 27203692


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Programmed Cell Death Poster

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Pathways for AT 101

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.