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AT 101 is a R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.
AT 101 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 518.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||9.64 mL||48.21 mL||96.42 mL|
|1 mM||1.93 mL||9.64 mL||19.28 mL|
|2 mM||0.96 mL||4.82 mL||9.64 mL|
|10 mM||0.19 mL||0.96 mL||1.93 mL|
References are publications that support the biological activity of the product.
Balakrishnan et al (2009) AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood 113 149 PMID: 18836097
Kline et al (2008) R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells. Exp.Hematol. 36 568 PMID: 18346839
Loberg et al (2007) In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. Neoplasia 9 1030 PMID: 18084610
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Keywords: AT 101, AT 101 supplier, downregulates, Bcl-2, Mcl-1, proapoptotic, apoptosis, inducer, gossypol, Bcl, AT101, Family, Apoptosis, Inducers, 3367, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for AT 101 include:
Chen et al (2016) Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells. World J Gastroenterol 11 e0156145 PMID: 27203692
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.