R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 518.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.93 mL||9.64 mL||19.28 mL|
|5 mM||0.39 mL||1.93 mL||3.86 mL|
|10 mM||0.19 mL||0.96 mL||1.93 mL|
|50 mM||0.04 mL||0.19 mL||0.39 mL|
References are publications that support the products' biological activity.
Balakrishnan et al (2009) AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood 113 149 PMID: 18836097
Kline et al (2008) R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells. Exp.Hematol. 36 568 PMID: 18346839
Loberg et al (2007) In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. Neoplasia 9 1030 PMID: 18084610
If you know of a relevant reference for AT 101, please let us know.
Keywords: AT 101, supplier, downregulates, Bcl-2, Mcl-1, proapoptotic, apoptosis, inducer, gossypol, Bcl, AT101, Bcl-2, Family, Apoptosis, Inducers, Bcl-2, Family, Tocris Bioscience
1 Citation for AT 101
Citations are publications that use Tocris products. Selected citations for AT 101 include:
Chen et al (2016) Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells. World J Gastroenterol 11 e0156145 PMID: 27203692
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