Potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC50 = 10 nM). Displays >200 fold selectivity over HDAC isoforms 1, 2, 3, 6 and 10. Induces apoptosis in cell lines derived from T cell lymphomas or leukemias.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 296.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.37 mL||16.87 mL||33.75 mL|
|5 mM||0.67 mL||3.37 mL||6.75 mL|
|10 mM||0.34 mL||1.69 mL||3.37 mL|
|50 mM||0.07 mL||0.34 mL||0.67 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Pipalia et al (2011) Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts. Proc.Natl.Acad.Sci.U.S.A. 108 5620 PMID: 21436030
Balasubramanian et al (2008) A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. Leukemia 22 1026 PMID: 18256683
If you know of a relevant reference for PCI 34051, please let us know.
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Keywords: PCI 34051, supplier, PCI34051, potent, selective, histone, deacetylase, 8, (HDAC8), inhibitors, inhibits, epigenetics, Histone, Deacetylases, Apoptosis, Inducers, Histone, Deacetylases, Tocris Bioscience
Citations for PCI 34051
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