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Apoptosis Inducers

Apoptosis inducers exhibit pro-apoptotic effects through a variety of mechanisms, including DNA cross-linking, inhibition of antiapoptotic proteins and activation of caspases. These inducers may target a specific cellular process in order to induce antitumor or antineoplastic effects.

Products
Literature
Pathways
Cat No Product Name / Activity
1229 Actinomycin D
Antineoplastic antibiotic
5330 AEG 40730 dihydrochloride
IAP antagonist; induces apoptosis
4846 Apicidin
Potent histone deacetylase inhibitor; induces apoptosis
2098 Apoptosis Activator 2
Selectively induces tumor cell apoptosis
3367 AT 101
Downregulates Bcl-2 and Mcl-1; pro-apoptotic
4810 BAM 7
Selective Bax activator; induces Bax-mediated apoptosis
3681 Bendamustine hydrochloride
Cytostatic agent; exhibits DNA alkylating and purine analog properties
3906 Betulinic acid
Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
5372 Bioymifi
DR5 (TRAIL receptor) agonist; induces apoptosis
5791 Bz 423
ATP synthase inhibitor; proapoptotic
2489 C 75
Induces apoptosis and exhibits anti-tumor activity
2626 Carboplatin
DNA cross-linking antitumor agent
5144 CFM 4
CARP-1 mimetic; proapoptotic
5804 Chaetoglobosin A
Selectively induces apoptosis of CLL cells; antibiotic
3868 CHM 1
Potent antitumor agent; inducer of apoptosis
5800 CHMFL-FLT3-122
Induces apoptosis; FLT3 inhibitor
2251 Cisplatin
DNA-alkylating antitumor agent
5292 Cladribine
Deoxyadenosine analog; pro-apoptotic
5973 CP 724714
Potent and selective ErbB2 inhibitor; promotes tumor apoptosis
2841 Curcumin
Antitumor, anti-inflammatory and antioxidant
4091 Cyclophosphamide
Alkylating agent; chemotherapeutic
2137 2,3-DCPE hydrochloride
Selectively induces cancer cell apoptosis
1770 Deguelin
Anticancer and antiviral agent; chemopreventive and pro-apoptotic
2252 Doxorubicin hydrochloride
Antitumor antibiotic agent; induces apoptosis
4808 FK 866 hydrochloride
Non-competitive and potent NAMPT inhibitor; induces apoptosis and autophagy
3495 Fludarabine
Proapoptotic; increases Bax and decreases Bid, XIAP and survivin expression
3590 Gambogic acid
Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins
3603 Kaempferol
Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
1807 2-Methoxyestradiol
Apoptotic and antiangiogenic agent
3258 Mitomycin C
DNA cross-linking antitumor agent
5231 MPC 6827 hydrochloride
Inhibitor of microtubule polymerization; antimitotic and antitumor
3715 Narciclasine
Antiproliferative agent; exhibits pro-apoptotic effects
4566 NSC 687852
Inhibitor UCHL5 and USP14; induces apoptosis
6026 Oleanolic acid
Selective GPBA receptor (TGR5) partial agonist; apoptosis inducer
3427 Oncrasin 1
Proapoptotic; induces abnormal nuclear accumulation of PKCι
2623 Oxaliplatin
DNA cross-linking antitumor agent
4643 PCI 34051
Potent and selective histone deacetylase 8 (HDAC8) inhibitor; induces apoptosis in T cell-derived cell lines
4396 Piperlongumine
Induces apoptosis; increases p53 and ROS levels in cancer cells
4761 Plumbagin
Induces apoptosis; anticancer
5359 Rifaximin
Apoptosis inducer; pregnane X receptor agonist and antibiotic
5314 SMBA 1
High affinity and selective activator of Bax
1621 Streptozocin
DNA alkylator; antitumor and induces diabetes
2706 Temozolomide
DNA-methylating antitumor agent
3909 Toceranib
Potent PDGFR and VEGFR inhibitor; induces apoptosis
4038 TW 37
Bcl-2 inhibitor; induces apoptosis

Literature for Apoptosis Inducers

Tocris offers the following scientific literature for Apoptosis Inducers to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Apoptosis Inducers

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.