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Apoptosis Inducers

Apoptosis inducers exhibit pro-apoptotic effects through a variety of mechanisms, including DNA cross-linking, inhibition of antiapoptotic proteins and activation of caspases. These inducers may target a specific cellular process in order to induce antitumor or antineoplastic effects.

Products
Literature (1)
Pathways (1)
Cat. No. Product Name / Activity
1229 Actinomycin D
Antineoplastic antibiotic
2098 Apoptosis Activator 2
Selectively induces tumor cell apoptosis
3367 AT 101
Downregulates Bcl-2 and Mcl-1; pro-apoptotic
3906 Betulinic acid
Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
5791 Bz 423
ATP synthase inhibitor; proapoptotic
2489 C 75
Induces apoptosis and exhibits anti-tumor activity
2626 Carboplatin
DNA cross-linking antitumor agent
2251 Cisplatin
DNA-alkylating antitumor agent
4091 Cyclophosphamide
Alkylating agent; chemotherapeutic
2252 Doxorubicin hydrochloride
Antitumor antibiotic agent; induces apoptosis
7507 Evofosfamide
Hypoxia-activated DNA alkylating agent prodrug
8072 FK 866
Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
3495 Fludarabine
Proapoptotic; increases Bax and decreases Bid, XIAP and survivin expression
3603 Kaempferol
Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
6617 LYN 1604 dihydrochloride
Induces apoptosis; ULK1 agonist
3258 Mitomycin C
DNA cross-linking antitumor agent
3715 Narciclasine
Antiproliferative agent; exhibits pro-apoptotic effects
2623 Oxaliplatin
DNA cross-linking antitumor agent
4643 PCI 34051
Potent and selective histone deacetylase 8 (HDAC8) inhibitor; induces apoptosis in T cell-derived cell lines
5314 SMBA 1
High affinity and selective activator of Bax
1621 Streptozocin
DNA alkylator; antitumor and induces diabetes
2706 Temozolomide
DNA-methylating antitumor agent

Related Targets

    Literature for Apoptosis Inducers

    Tocris offers the following scientific literature for Apoptosis Inducers to showcase our products. We invite you to request* your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.

    Programmed Cell Death Poster

    Programmed Cell Death Poster

    There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

    Pathways for Apoptosis Inducers

    Apoptosis Signaling Pathway

    Apoptosis Signaling Pathway

    Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.