Apoptosis Inducers
Apoptosis inducers exhibit pro-apoptotic effects through a variety of mechanisms, including DNA cross-linking, inhibition of antiapoptotic proteins and activation of caspases. These inducers may target a specific cellular process in order to induce antitumor or antineoplastic effects.
| Cat. No. | Product Name / Activity |
|---|---|
| 1229 | Actinomycin D |
| Antineoplastic antibiotic | |
| 5330 | AEG 40730 dihydrochloride |
| IAP antagonist; induces apoptosis | |
| 2098 | Apoptosis Activator 2 |
| Selectively induces tumor cell apoptosis | |
| 3367 | AT 101 |
| Downregulates Bcl-2 and Mcl-1; pro-apoptotic | |
| 4810 | BAM 7 |
| Selective Bax activator; induces Bax-mediated apoptosis | |
| 3681 | Bendamustine hydrochloride |
| Cytostatic agent; exhibits DNA alkylating and purine analog properties | |
| 3906 | Betulinic acid |
| Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist | |
| 5372 | Bioymifi |
| DR5 (TRAIL receptor) agonist; induces apoptosis | |
| 5791 | Bz 423 |
| ATP synthase inhibitor; proapoptotic | |
| 2489 | C 75 |
| Induces apoptosis and exhibits anti-tumor activity | |
| 2626 | Carboplatin |
| DNA cross-linking antitumor agent | |
| 5144 | CFM 4 |
| CARP-1 mimetic; proapoptotic | |
| 5804 | Chaetoglobosin A |
| Selectively induces apoptosis of CLL cells; antibiotic | |
| 5800 | CHMFL-FLT3-122 |
| Induces apoptosis; FLT3 inhibitor | |
| 2251 | Cisplatin |
| DNA-alkylating antitumor agent | |
| 5292 | Cladribine |
| Deoxyadenosine analog; pro-apoptotic | |
| 5973 | CP 724714 |
| Potent and selective ErbB2 inhibitor; promotes tumor apoptosis | |
| 2841 | Curcumin |
| Antitumor, anti-inflammatory and antioxidant | |
| 4091 | Cyclophosphamide |
| Alkylating agent; chemotherapeutic | |
| 2137 | 2,3-DCPE hydrochloride |
| Selectively induces cancer cell apoptosis | |
| 2252 | Doxorubicin hydrochloride |
| Antitumor antibiotic agent; induces apoptosis | |
| 4808 | FK 866 hydrochloride |
| Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy | |
| 3495 | Fludarabine |
| Proapoptotic; increases Bax and decreases Bid, XIAP and survivin expression | |
| 6776 | G5 |
| Activates apoptosis in an apoptosome-independent pathway; ubiquitin isopeptidase inhibitor | |
| 3590 | Gambogic acid |
| Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins | |
| 3603 | Kaempferol |
| Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter | |
| 1807 | 2-Methoxyestradiol |
| Apoptotic and antiangiogenic agent | |
| 3258 | Mitomycin C |
| DNA cross-linking antitumor agent | |
| 5231 | MPC 6827 hydrochloride |
| Inhibitor of microtubule polymerization; antimitotic and antitumor | |
| 3715 | Narciclasine |
| Antiproliferative agent; exhibits pro-apoptotic effects | |
| 4566 | NSC 687852 |
| Inhibitor UCHL5 and USP14; induces apoptosis | |
| 6026 | Oleanolic acid |
| Selective GPBA receptor (TGR5) partial agonist; apoptosis inducer | |
| 3427 | Oncrasin 1 |
| Proapoptotic; induces abnormal nuclear accumulation of PKCι | |
| 2623 | Oxaliplatin |
| DNA cross-linking antitumor agent | |
| 4643 | PCI 34051 |
| Potent and selective histone deacetylase 8 (HDAC8) inhibitor; induces apoptosis in T cell-derived cell lines | |
| 4396 | Piperlongumine |
| Induces apoptosis; increases p53 and ROS levels in cancer cells | |
| 4761 | Plumbagin |
| Induces apoptosis; anticancer | |
| 5359 | Rifaximin |
| Apoptosis inducer; pregnane X receptor agonist and antibiotic | |
| 5314 | SMBA 1 |
| High affinity and selective activator of Bax | |
| 1621 | Streptozocin |
| DNA alkylator; antitumor and induces diabetes | |
| 2706 | Temozolomide |
| DNA-methylating antitumor agent | |
| 3909 | Toceranib |
| Potent PDGFR and VEGFR inhibitor; induces apoptosis | |
| 4038 | TW 37 |
| Bcl-2 inhibitor; induces apoptosis |
Literature for Apoptosis Inducers
Tocris offers the following scientific literature for Apoptosis Inducers to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Apoptosis Inducers
Apoptosis Signaling Pathway
Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.
Our Cancer Research Guide highlights over 750 products for cancer research.
Request copyRequest PDFWritten by Bram van Raam and Guy Salvesen
Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival.
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