Apoptosis Inducers

Apoptosis inducers exhibit pro-apoptotic effects through a variety of mechanisms, including DNA cross-linking, inhibition of antiapoptotic proteins and activation of caspases. These inducers may target a specific cellular process in order to induce antitumor or antineoplastic effects.

Products

Literature

Pathways

Cat No	Product Name / Activity
1229	Actinomycin D
	Antineoplastic antibiotic
5330	AEG 40730 dihydrochloride
	IAP antagonist; induces apoptosis
4846	Apicidin
	Potent histone deacetylase inhibitor; induces apoptosis
2098	Apoptosis Activator 2
	Selectively induces tumor cell apoptosis
3367	AT 101
	Downregulates Bcl-2 and Mcl-1; pro-apoptotic
4810	BAM 7
	Selective Bax activator; induces Bax-mediated apoptosis
3681	Bendamustine hydrochloride
	Cytostatic agent; exhibits DNA alkylating and purine analog properties
3906	Betulinic acid
	Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
5372	Bioymifi
	DR5 (TRAIL receptor) agonist; induces apoptosis
5791	Bz 423
	ATP synthase inhibitor; proapoptotic
2489	C 75
	Induces apoptosis and exhibits anti-tumor activity
2626	Carboplatin
	DNA cross-linking antitumor agent
5144	CFM 4
	CARP-1 mimetic; proapoptotic
5804	Chaetoglobosin A
	Selectively induces apoptosis of CLL cells; antibiotic
3868	CHM 1
	Potent antitumor agent; inducer of apoptosis
5800	CHMFL-FLT3-122
	Induces apoptosis; FLT3 inhibitor
2251	Cisplatin
	DNA-alkylating antitumor agent
5292	Cladribine
	Deoxyadenosine analog; pro-apoptotic
5973	CP 724714
	Potent and selective ErbB2 inhibitor; promotes tumor apoptosis
2841	Curcumin
	Antitumor, anti-inflammatory and antioxidant
4091	Cyclophosphamide
	Alkylating agent; chemotherapeutic
2137	2,3-DCPE hydrochloride
	Selectively induces cancer cell apoptosis
1770	Deguelin
	Anticancer and antiviral agent; chemopreventive and pro-apoptotic
2252	Doxorubicin hydrochloride
	Antitumor antibiotic agent; induces apoptosis
4808	FK 866 hydrochloride
	Non-competitive and potent NAMPT inhibitor; induces apoptosis and autophagy
3495	Fludarabine
	Proapoptotic; increases Bax and decreases Bid, XIAP and survivin expression
3590	Gambogic acid
	Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins
3603	Kaempferol
	Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca²⁺ uniporter
1807	2-Methoxyestradiol
	Apoptotic and antiangiogenic agent
3258	Mitomycin C
	DNA cross-linking antitumor agent
5231	MPC 6827 hydrochloride
	Inhibitor of microtubule polymerization; antimitotic and antitumor
3715	Narciclasine
	Antiproliferative agent; exhibits pro-apoptotic effects
4566	NSC 687852
	Inhibitor UCHL5 and USP14; induces apoptosis
6026	Oleanolic acid
	Selective GPBA receptor (TGR5) partial agonist; apoptosis inducer
3427	Oncrasin 1
	Proapoptotic; induces abnormal nuclear accumulation of PKCι
2623	Oxaliplatin
	DNA cross-linking antitumor agent
4643	PCI 34051
	Potent and selective histone deacetylase 8 (HDAC8) inhibitor; induces apoptosis in T cell-derived cell lines
4396	Piperlongumine
	Induces apoptosis; increases p53 and ROS levels in cancer cells
4761	Plumbagin
	Induces apoptosis; anticancer
5359	Rifaximin
	Apoptosis inducer; pregnane X receptor agonist and antibiotic
5314	SMBA 1
	High affinity and selective activator of Bax
1621	Streptozocin
	DNA alkylator; antitumor and induces diabetes
2706	Temozolomide
	DNA-methylating antitumor agent
3909	Toceranib
	Potent PDGFR and VEGFR inhibitor; induces apoptosis
4038	TW 37
	Bcl-2 inhibitor; induces apoptosis

Literature for Apoptosis Inducers

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

Cancer Metabolism
Epigenetics in Cancer
Receptor Signaling
Cell Cycle and DNA Damage Repair
Angiogenesis
Invasion and Metastasis

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Apoptosis Inducers

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.