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Description: High affinity and selective activator of Bax
Chemical Name: 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol
Purity: ≥98% (HPLC)
Literature (2)
Pathways (1)

Biological Activity for SMBA 1

SMBA 1 is a high affinity and selective activator of Bax (Ki = 43.3 nM). Binds to the S184 binding pocket to block Bax phosphorylation. Does not bind to other Bcl-2 family members, including Bcl-2, Bak and Bid. Facilitates Bax insertion into the mitochondrial membrane and promotes Bax-dependent cytochrome c release. Induces apoptosis in lung cancer cell lines expressing high levels of Bax selectively over normal cells expressing low levels of Bax. Represses tumor growth of A549 lung cancer xenografts in mice.

Technical Data for SMBA 1

M. Wt 315.32
Formula C20H13NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 906440-37-7
PubChem ID 349156
Smiles OC(C=CC=C4)=C4\C=C2C3=C(C=CC([N+]([O-])=O)=C3)C1=CC=CC=C1/2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SMBA 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.53 100
ethanol 3.15 10 with gentle warming

Preparing Stock Solutions for SMBA 1

The following data is based on the product molecular weight 315.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.17 mL 15.86 mL 31.71 mL
5 mM 0.63 mL 3.17 mL 6.34 mL
10 mM 0.32 mL 1.59 mL 3.17 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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References for SMBA 1

References are publications that support the biological activity of the product.

Xin et al (2014) Small-molecule Bax agonists for cancer therapy. Nat.Commun. 5 4935 PMID: 25230299

If you know of a relevant reference for SMBA 1, please let us know.

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Citations for SMBA 1

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Parkinson's Disease Poster

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Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for SMBA 1

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.