SMBA 1

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Cat.No. 5314 - SMBA 1 | C20H13NO3 | CAS No. 906440-37-7
Description: High affinity and selective activator of Bax
Chemical Name: 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

High affinity and selective activator of Bax (Ki = 43.3 nM). Binds to the S184 binding pocket to block Bax phosphorylation. Does not bind to other Bcl-2 family members, including Bcl-2, Bak and Bid. Facilitates Bax insertion into the mitochondrial membrane and promotes Bax-dependent cytochrome c release. Induces apoptosis in lung cancer cell lines expressing high levels of Bax selectively over normal cells expressing low levels of Bax. Represses tumor growth of A549 lung cancer xenografts in mice.

Technical Data

M. Wt 315.32
Formula C20H13NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 906440-37-7
PubChem ID 349156
InChI Key PEYKRJBXACUOOB-UHFFFAOYSA-N
Smiles OC(C=CC=C4)=C4\C=C2C3=C(C=CC([N+]([O-])=O)=C3)C1=CC=CC=C1/2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 3.15 10 with gentle warming
DMSO 31.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 315.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.17 mL 15.86 mL 31.71 mL
5 mM 0.63 mL 3.17 mL 6.34 mL
10 mM 0.32 mL 1.59 mL 3.17 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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References

References are publications that support the biological activity of the product.

Xin et al (2014) Small-molecule Bax agonists for cancer therapy. Nat.Commun. 5 4935 PMID: 25230299


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Citations for SMBA 1

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

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Parkinson's

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Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for SMBA 1

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.