C 75

Pricing Availability   Qty
Description: Potent fatty acid synthase inhibitor; proapoptotic
Alternative Names: trans-C 75
Chemical Name: (2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid
Purity: ≥95% (HPLC)
Citations (1)
Literature (1)

Biological Activity for C 75

C 75 is a synthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitro and in vivo. Displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits antitumor activity.

Compound Libraries for C 75

C 75 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for C 75

M. Wt 254.32
Formula C14H22O4
Storage Store at +4°C
Purity ≥95% (HPLC)
CAS Number 191282-48-1
PubChem ID 90488767
Smiles C=C([C@@H]([C@](O)=O)[C@H](CCCCCCCC)O1)C1=O.C=C([C@H](C(O)=O)[C@@H](CCCCCCCC)O2)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for C 75

Solvent Max Conc. mg/mL Max Conc. mM
1eq. NaOH 25.43 100
DMSO 25.43 100

Preparing Stock Solutions for C 75

The following data is based on the product molecular weight 254.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.66 mL 39.32 mL
5 mM 0.79 mL 3.93 mL 7.86 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets for C 75

Certificate of Analysis / Product Datasheet
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References for C 75

References are publications that support the biological activity of the product.

Zhou et al (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 63 7330 PMID: 14612531

Takahashi et al (2004) The anorexigenic fatty acid synthase inhibitor, C45, is a nonspecific neuronal activator. Endocrinology 145 184 PMID: 14512433

Kuhajda et al (2000) Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc.Natl.Acad.Sci. 97 3450

Thupari et al (2004) Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. Am.J.Physiol.Endocrinol.Metab. 287 97

If you know of a relevant reference for C 75, please let us know.

View Related Products by Product Action

View all Fatty Acid Synthase Inhibitors

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1 Citation for C 75

Citations are publications that use Tocris products. Selected citations for C 75 include:

Sadowski et al (2014) The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer. Oncotarget 5 9362 PMID: 25313139

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including: