C 75

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Cat.No. 2489 - C 75 | C14H22O4 | CAS No. 191282-48-1
Description: Potent fatty acid synthase inhibitor; proapoptotic
Alternative Names: trans-C 75
Chemical Name: (2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Synthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitro and in vivo. Displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits anti-tumor activity.

Technical Data

M. Wt 254.32
Formula C14H22O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 191282-48-1
PubChem ID 90488767
InChI Key VHOGWRFOUWVZQX-FBVLPHPLSA-N
Smiles C=C([C@@H]([C@](O)=O)[C@H](CCCCCCCC)O1)C1=O.C=C([C@H](C(O)=O)[C@@H](CCCCCCCC)O2)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 25.43 100
DMSO 25.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 254.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.66 mL 39.32 mL
5 mM 0.79 mL 3.93 mL 7.86 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Zhou et al (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 63 7330 PMID: 14612531

Takahashi et al (2004) The anorexigenic fatty acid synthase inhibitor, C45, is a nonspecific neuronal activator. Endocrinology 145 184 PMID: 14512433

Kuhajda et al (2000) Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc.Natl.Acad.Sci. 97 3450 PMID:

Thupari et al (2004) Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. Am.J.Physiol.Endocrinol.Metab. 287 97 PMID:


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Citations for C 75

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

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