Inhibitor of Apoptosis

The inhibitor of apoptosis (IAP) family of proteins are major regulators of apoptosis through interaction with components of the apoptotic signaling cascades. Discovered in baculovirus, human homologs can be described as baculovirus IAP repeat containing (BIRC) proteins.

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Background
Literature
Pathways
Gene Data

Inhibitors

Cat No Product Name / Activity
5141 AZD 5582 dihydrochloride
Dimeric Smac mimetic; potent IAP inhibitor
2156 Embelin
Inhibitor of X-linked inhibitor of apoptosis (XIAP); cell-permeable and antitumor
5251 UC 112
IAP and XIAP inhibitor; antitumor

Other

Cat No Product Name / Activity
3253 Triptolide
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

Related Targets

    Inhibitors of apoptosis (IAP) are a family of proteins that are the major regulators of apoptosis through their interaction with the various components of the apoptotic signaling cascades. Originally discovered in baculovirus, the human homologs are sometimes described as baculovirus IAP repeat containing (BIRC) proteins.

    There are a number of different IAPs including neuronal apoptosis inhibitory protein (NAIP or BIRC1), cellular IAPs (c-IAP-1 and c-IAP-2, or BIRC2 and BIRC3 respectively), X-chromosome linked IAP (XIAP or BIRC4) and survivin (BIRC5). cIAP-1 and 2 function through interaction with TNF receptors and by binding to the mitochondrial protein, SMAC, preventing it binding to XIAP. Thought to be the most potent apoptosis suppressor, XIAP, directly binds and inhibits caspases -3, -7 and -9. Survivin, which also binds to several caspases, is up-regulated in a many tumor cell types.

    Literature for Inhibitor of Apoptosis

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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    Programmed Cell Death

    Programmed Cell Death Poster

    There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

    Pathways for Inhibitor of Apoptosis

    Apoptosis

    Apoptosis Signaling Pathway

    Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

    Inhibitor of Apoptosis Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    NIAP Human NAIP NM_004536 Q13075
    Mouse Naip1 NM_008670 Q9QWK5
    Rat Naip2 XM_226742 Q8R4U8
    c-IAP-1 Human BIRC2 NM_001166 Q13490
    Mouse Birc2 NM_007465 Q62210
    Rat Birc2 NM_021752 O88642
    c-IAP-2 Human BIRC3 NM_001165 Q13489
    Mouse Birc3 NM_007464 O08863
    Rat Birc3 NM_023987 Q9ESE9
    XIAP Human XIAP NM_001167 P98170
    Mouse Xiap NM_009688 Q60989
    Rat Xiap NM_022231 Q9R0I6
    Survivin Human BIRC5 NM_001168 O15392
    Mouse Birc5 NM_001012273 O70201
    Rat Birc5 NM_022274 Q9JHY7