The inhibitor of apoptosis (IAP) family of proteins are major regulators of apoptosis through interaction with components of the apoptotic signaling cascades. Discovered in baculovirus, human homologs can be described as baculovirus IAP repeat containing (BIRC) proteins.
Inhibitor of Apoptosis Inhibitors |
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Cat. No. | Product Name / Activity |
6470 | A 410099.1 |
High affinity XIAP antagonist; active in vivo | |
5141 | AZD 5582 dihydrochloride |
Dimeric Smac mimetic; potent IAP inhibitor | |
5251 | UC 112 |
IAP and XIAP inhibitor; antitumor | |
6491 | YM 155 |
Survivin suppressor | |
Other |
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Cat. No. | Product Name / Activity |
3253 | Triptolide |
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive |
Inhibitors of apoptosis (IAP) are a family of proteins that are the major regulators of apoptosis through their interaction with the various components of the apoptotic signaling cascades. Originally discovered in baculovirus, the human homologs are sometimes described as baculovirus IAP repeat containing (BIRC) proteins.
There are a number of different IAPs including neuronal apoptosis inhibitory protein (NAIP or BIRC1), cellular IAPs (c-IAP-1 and c-IAP-2, or BIRC2 and BIRC3 respectively), X-chromosome linked IAP (XIAP or BIRC4) and survivin (BIRC5). cIAP-1 and 2 function through interaction with TNF receptors and by binding to the mitochondrial protein, SMAC, preventing it binding to XIAP. Thought to be the most potent apoptosis suppressor, XIAP, directly binds and inhibits caspases -3, -7 and -9. Survivin, which also binds to several caspases, is up-regulated in a many tumor cell types.
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There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
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NIAP | Human | NAIP | NM_004536 | Q13075 |
Mouse | Naip1 | NM_008670 | Q9QWK5 | |
Rat | Naip2 | XM_226742 | Q8R4U8 | |
c-IAP-1 | Human | BIRC2 | NM_001166 | Q13490 |
Mouse | Birc2 | NM_007465 | Q62210 | |
Rat | Birc2 | NM_021752 | O88642 | |
c-IAP-2 | Human | BIRC3 | NM_001165 | Q13489 |
Mouse | Birc3 | NM_007464 | O08863 | |
Rat | Birc3 | NM_023987 | Q9ESE9 | |
XIAP | Human | XIAP | NM_001167 | P98170 |
Mouse | Xiap | NM_009688 | Q60989 | |
Rat | Xiap | NM_022231 | Q9R0I6 | |
Survivin | Human | BIRC5 | NM_001168 | O15392 |
Mouse | Birc5 | NM_001012273 | O70201 | |
Rat | Birc5 | NM_022274 | Q9JHY7 |