ASK1

Apoptosis signal-regulated kinase 1 (ASK1) is a serine/threonine kinase, MAP3K family member, which induces apoptosis through the activation of JNK and p38. ASK1 has been implicated in the pathology of neurodegenerative and oxidative stress-related diseases.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5641 MSC 2032964A
Potent and selective ASK1 inhibitor; orally bioavailable
4429 NQDI 1
ASK1 inhibitor
4825 TC ASK 10
Potent and selective ASK1 inhibitor; orally bioavailable

Apoptosis signal-regulated kinase 1 (ASK1) is a ubiquitously expressed serine/threonine kinase which induces apoptosis in a wide variety of cell types. ASK1 is a member of the MAP3K family and is therefore part of the MAPK signaling pathway. The kinase activates JNK and p38 through phosphorylation of SEK1/MKK7 and MKK3/MKK6 respectively, which induces mitochondria-dependent caspase activation and subsequent apoptosis. ASK1 is activated following auto-phosphorylation of Thr845 (mouse)/Thr838 (human) in the activation loop of its kinase domain, whilst Raf1 and the 14.3.3 proteins interact with ASK1 to suppress its proapoptotic activity.

ASK1-induced apoptosis can be activated by a number of stimuli, including: reactive oxygen species (ROS) such as hydrogen peroxide; death receptor ligands e.g. TNF-α and Fas ligand; endoplasmic reticulum (ER) stress; and lipopolysaccharide, GPCR and Ca2+ signaling. ASK1 has been implicated in the pathology of oxidative stress-related disease states such as ischemia-reperfusion injury and hematopoietic diseases, as well as in the role of ER stress in the pathogenesis of neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's disease.

Literature for ASK1

Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

ASK1 Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ASK1 Human MAP3K5 NM_005923 Q99683
Mouse Map3k5 NM_008580 Q14AY4
Rat Map3k5 NM_001277694 NP_001264623