You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Betulinic acid
Betulinic acid is a natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Also a GPBA receptor partial agonist (EC50 = 1.04 μM, efficacy 83%).
Technical Data for Betulinic acid
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Betulinic acid
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Betulinic acid
The following data is based on the product molecular weight 456.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.38 mL||21.9 mL||43.79 mL|
|2.5 mM||0.88 mL||4.38 mL||8.76 mL|
|5 mM||0.44 mL||2.19 mL||4.38 mL|
|25 mM||0.09 mL||0.44 mL||0.88 mL|
References for Betulinic acid
References are publications that support the biological activity of the product.
Kashiwada et al (1996) Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents. J.Med.Chem. 39 1016 PMID: 8676334
Fulda (2008) Betulinic acid for cancer treatment and prevention. Int.J.Mol.Sci. 9 1096 PMID: 19325847
Genet et al (2010) Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J.Med.Chem. 53 178 PMID: 19911773
If you know of a relevant reference for Betulinic acid, please let us know.
View Related Products by Target
Keywords: Betulinic acid, Betulinic acid supplier, antitumor, anti-HIV, NFkappaB, NF-kB, NFκB, TGR5, receptors, activators, activates, apoptosis, inducers, partial, agonists, agonism, Apoptosis, Inducers, NF-kB/IkB, GPBA, Receptors, 3906, Tocris Bioscience
1 Citation for Betulinic acid
Citations are publications that use Tocris products. Selected citations for Betulinic acid include:
Inoue et al (2012) Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Neurotox Res 303 G810 PMID: 22821947
Do you know of a great paper that uses Betulinic acid from Tocris? Please let us know.
Reviews for Betulinic acid
There are currently no reviews for this product. Be the first to review Betulinic acid and earn rewards!
Have you used Betulinic acid?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.