NF-κB and IκB Inhibitors

Cat. No.	Product Name / Activity
4547	ACHP
	Selective IKKα and IKKβ inhibitor; blocks NF-κB-DNA binding
4857	Amlexanox
	Inhibitor of TBK1 and IKKε; antiallergic agent
1777	Arctigenin
	Inhibitor of IκBα phosphorylation. Also inhibits MEK1
1743	Bay 11-7085
	Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
1744	Bay 11-7821
	Indirect inhibitor of IκBα phosphorylation
5300	BI 605906
	Selective IKKβ inhibitor
4806	BMS 345541
	Selective allosteric inhibitor of IKK; anti-inflammatory
5821	C-DIM 12
	Inhibits NF-κB-dependent gene expression; Nurr1 activator
2743	Caffeic acid phenethyl ester
	Specific inhibitor of NF-κB activation
2509	Cardamonin
	Inhibitor of NF-κB activation; anti-inflammatory
6646	CDDO-Me
	NF-κB pathway inhibitor; inhibits IKKβ; also Nrf2 pathway activator
3203	Celastrol
	Inhibits TNF-α-induced NF-κB activation
6237	FPS ZM1
	High affinity antagonist of the receptor for advanced glycation end products (RAGE)
5672	GSK 319347A
	Potent and selective IKKε inhibitor
4590	Honokiol
	Blocks NF-κB activation; also anti-inflammatory and antioxidant
2539	IKK 16
	Selective inhibitor of IKK
2611	IMD 0354
	Inhibitor of IKKβ
5699	IP7e
	Blocks NF-κB pathway; also potent Nurr1 activator
2874	Luteolin
	Blocks NF-κB activation
1748	MG 132
	Inhibits NF-κB activation; proteasome and calpain inhibitor
4899	ML 120B dihydrochloride
	Novel IKK2-selective inhibitor
7136	NIKi New
	Potent NIK inhibitor
4238	PF 184
	Potent and selective IKKβ inhibitor
1554	Piceatannol
	Inhibits TNF-induced NF-κB activation
4569	PS 1145 dihydrochloride
	Selective IKK inhibitor; orally active
6259	RAGE antagonist peptide
	Receptor for advanced glycation end products (RAGE) antagonist
3318	SC 514
	IKKβ inhibitor; attenuates NF-κB-induced gene expression
6829	(R)-Shikonin
	Blocks TNF-α and NF-κB signaling; induces necroptosis; anti-inflammatory
5309	SP 100030
	NF-κB and AP-1 dual inhibitor
4935	Sulfasalazine
	Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1
2559	TPCA-1
	Potent, selective inhibitor of IKKβ
2816	Withaferin A
	Inhibits NF-κB activation
6111	Zoledronic Acid
	NF-κB signaling inhibitor; also potent farnesyl diphosphate (FPP) synthase inhibitor