NF-κB and IκB Inhibitors

Cat. No. Product Name / Activity
4547 ACHP
Selective IKKα and IKKβ inhibitor; blocks NF-κB-DNA binding
4857 Amlexanox
Inhibitor of TBK1 and IKKε; antiallergic agent
4626 Andrographolide
Inhibits NFκB; blocks androgen receptor (AR) expression
1777 Arctigenin
Inhibitor of IκBα phosphorylation. Also inhibits MEK1
1743 Bay 11-7085
Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
1744 Bay 11-7821
Indirect inhibitor of IκBα phosphorylation
5273 Bengamide B
Potent inhibitor of NF-κB activation
5300 BI 605906
Selective IKKβ inhibitor
4806 BMS 345541
Selective allosteric inhibitor of IKK; anti-inflammatory
5821 C-DIM 12
Inhibits NF-κB-dependent gene expression; Nurr1 activator
2743 Caffeic acid phenethyl ester
Specific inhibitor of NF-κB activation
2509 Cardamonin
Inhibitor of NF-κB activation; anti-inflammatory
6646 CDDO-Me
NF-κB pathway inhibitor; inhibits IKKβ; also Nrf2 pathway activator
3203 Celastrol
Inhibits TNF-α-induced NF-κB activation
4246 CID 2858522
Selectively inhibits PKC-induced NF-κB activation
6237 FPS ZM1
High affinity antagonist of the receptor for advanced glycation end products (RAGE)
2637 Gliotoxin
Immunosuppressant; inhibits NF-κB and cytokine production
5672 GSK 319347A
Potent and selective IKKε inhibitor
4590 Honokiol
Blocks NF-κB activation; also anti-inflammatory and antioxidant
2861 HU 211
NF-κB inhibitor; decreases TNF-α, IL-6 and NO production. Also NMDA antagonist
2539 IKK 16
Selective inhibitor of IKK
2611 IMD 0354
Inhibitor of IKKβ
5699 IP7e
Blocks NF-κB pathway; also potent Nurr1 activator
5846 IT 901
NF-κB c-Rel subunit inhibitor
2874 Luteolin
Blocks NF-κB activation
1748 MG 132
Inhibits NF-κB activation; proteasome and calpain inhibitor
4899 ML 120B dihydrochloride
Novel IKK2-selective inhibitor
4354 ML 130
Inhibits NOD1-induced NF-κB activation
0610 Parthenolide
NF-κB inhibitor; also 5-HT release inhibitor
4238 PF 184
Potent and selective IKKβ inhibitor
1554 Piceatannol
Inhibits TNF-induced NF-κB activation
1947 PR 39 (porcine)
IκBα inhibitor
3731 Pristimerin
Suppresses NF-κB activation
4569 PS 1145 dihydrochloride
Selective IKK inhibitor; orally active
0727 Pyrrolidinedithiocarbamate ammonium
Inhibits NF-κB, prevents increase in NOS mRNA
6259 RAGE antagonist peptide
Receptor for advanced glycation end products (RAGE) antagonist
1778 Ro 106-9920
Inhibitor of NF-κB activation
3318 SC 514
IKKβ inhibitor; attenuates NF-κB-induced gene expression
6829 (R)-Shikonin
Blocks TNF-α and NF-κB signaling; induces necroptosis; anti-inflammatory
5309 SP 100030
NF-κB and AP-1 dual inhibitor
4935 Sulfasalazine
Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1
4426 Tanshinone IIA
Inhibits NF-κB and AP-1 DNA binding. Displays antioxidant properties
2559 TPCA-1
Potent, selective inhibitor of IKKβ
2816 Withaferin A
Inhibits NF-κB activation
6111 Zoledronic Acid
NF-κB signaling inhibitor; also potent farnesyl diphosphate (FPP) synthase inhibitor