You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Zoledronic Acid
Zoledronic Acid is a potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB.
Technical Data for Zoledronic Acid
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Zoledronic Acid
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Zoledronic Acid
The following data is based on the product molecular weight 272.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||7.35 mL||36.75 mL||73.51 mL|
|2.5 mM||1.47 mL||7.35 mL||14.7 mL|
|5 mM||0.74 mL||3.68 mL||7.35 mL|
|25 mM||0.15 mL||0.74 mL||1.47 mL|
References for Zoledronic Acid
References are publications that support the biological activity of the product.
Schech et al (2013) Zoledronic acid reverses the epithelial-mesenchymal transition and inhibits self-renewal of breast cancer cells through inactivation of NF-κB. Mol.Cancer Ther. 12 1356 PMID: 23619300
Tassone et al (2003) Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. Br.J.Cancer 88 1971 PMID: 12799645
Dunford et al (2001) Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J.Pharmacol.Exp.Ther. 296 235 PMID: 11160603
If you know of a relevant reference for Zoledronic Acid, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Zoledronic Acid, Zoledronic Acid supplier, bisphosphonate, NF-KB, NF-kappaB, NF-κB, signaling, inhibitors, inhibits, potent, FPP, synthase, farnesyl, diphosphate, Ras, Zometa, Other, Synthases/Synthetases, NF-kB/IkB, Cancer, Stem, Cells, GTPases, 6111, Tocris Bioscience
Citations for Zoledronic Acid
Citations are publications that use Tocris products.
Currently there are no citations for Zoledronic Acid. Do you know of a great paper that uses Zoledronic Acid from Tocris? Please let us know.
Reviews for Zoledronic Acid
There are currently no reviews for this product. Be the first to review Zoledronic Acid and earn rewards!
Have you used Zoledronic Acid?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.