Zoledronic Acid

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Cat.No. 6111 - Zoledronic Acid | C5H10N2O7P2 | CAS No. 118072-93-8
Description: Potent farnesyl diphosphate (FPP) synthase inhibitor
Alternative Names: Zometa
Chemical Name: [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB.

Technical Data

M. Wt 272.09
Formula C5H10N2O7P2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 118072-93-8
PubChem ID 68740
InChI Key XRASPMIURGNCCH-UHFFFAOYSA-N
Smiles OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 13.6 50
water 0.68 2.5

Preparing Stock Solutions

The following data is based on the product molecular weight 272.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.35 mL 36.75 mL 73.51 mL
2.5 mM 1.47 mL 7.35 mL 14.7 mL
5 mM 0.74 mL 3.68 mL 7.35 mL
25 mM 0.15 mL 0.74 mL 1.47 mL

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References

References are publications that support the biological activity of the product.

Schech et al (2013) Zoledronic acid reverses the epithelial-mesenchymal transition and inhibits self-renewal of breast cancer cells through inactivation of NF-κB. Mol.Cancer Ther. 12 1356 PMID: 23619300

Tassone et al (2003) Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. Br.J.Cancer 88 1971 PMID: 12799645

Dunford et al (2001) Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J.Pharmacol.Exp.Ther. 296 235 PMID: 11160603


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Keywords: Zoledronic Acid, Zoledronic Acid supplier, bisphosphonate, NF-KB, NF-kappaB, NF-κB, signaling, inhibitors, inhibits, potent, FPP, synthase, farnesyl, diphosphate, Ras, Zometa, Other, Synthases/Synthetases, NF-kB/IkB, Cancer, Stem, Cells, 6111, Tocris Bioscience

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis