Sulfasalazine

Pricing Availability Delivery Time Qty
Cat.No. 4935 - Sulfasalazine | C18H14N4O5S | CAS No. 599-79-1
Description: Inhibitor of NF-κB activation; also inhibits SXC
Chemical Name: 5-[[4-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature
Pathways

Biological Activity

Inhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system Xc (SXC). Anti-inflammatory.

Compound Libraries

Sulfasalazine is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 398.39
Formula C18H14N4O5S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 599-79-1
PubChem ID 5359476
InChI Key OQANPHBRHBJGNZ-BKUYFWCQSA-N
Smiles OC1=CC=C(/N=N/C2=CC=C(S(NC3=NC=CC=C3)(=O)=O)C=C2)C=C1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 398.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.1 mL
5 mM 0.5 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.26 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Robe et al (2004) In vitro and in vivo activity of the nuclear factor-κB inhbitor sulfasalazine in human glioblastomas. Clin.Cancer Res. 10 5595 PMID: 15328202

Lo et al (2010) Potential use fo the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer. Curr.Oncol. 17 9 PMID: 20567622

Sontheimer and Bridges (2012) Sulfasalazine for brain cancer fits. Expert Opin.Invest.Drugs 21 575 PMID: 22404218


If you know of a relevant reference for Sulfasalazine, please let us know.

View Related Products by Product Action

View all NF-κB and IκB Inhibitors

Keywords: Sulfasalazine, supplier, antirheumatic, antiinflammatories, antiinflammatory, arthritis, system, XC, SXC, cysteine-glutamate, antiporters, NF-kappaB, NF-kB, NF-κB, inhibitors, inhibits, NF-kB/IkB, NF-kB/IkB, Tocris Bioscience

1 Citation for Sulfasalazine

Citations are publications that use Tocris products. Selected citations for Sulfasalazine include:

Yeligar et al (2009) Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol 183 5964 PMID: 19828633


Do you know of a great paper that uses Sulfasalazine from Tocris? If so please let us know.

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Reviews

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Literature in this Area

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Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Pathways for Sulfasalazine

NF-κB

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.

Protocols

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