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Inhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system Xc (SXC). Inhibitor of folate transporter 1 (SLC19A1); inhibits cellular uptake of Methotrexate (Cat. No. 1230) and cyclic dinucleotides, including 2',3'-cGAMP (Cat.No. 5945). Anti-inflammatory. Induces ferroptosis.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 398.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.51 mL||12.55 mL||25.1 mL|
|5 mM||0.5 mL||2.51 mL||5.02 mL|
|10 mM||0.25 mL||1.26 mL||2.51 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
References are publications that support the biological activity of the product.
Robe et al (2004) In vitro and in vivo activity of the nuclear factor-κB inhbitor sulfasal. in human glioblastomas. Clin.Cancer Res. 10 5595 PMID: 15328202
Lo et al (2010) Potential use fo the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer. Curr.Oncol. 17 9 PMID: 20567622
Sontheimer and Bridges (2012) Sulfasalazine for brain cancer fits. Expert Opin.Invest.Drugs 21 575 PMID: 22404218
Jansen et al (2004) Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis. Arthritis Rheum. 50 2130 PMID: 15248210
Luteijn et al (2019) SLC19A1 transports immunoreactive cyclic dinucleotides. Nature 573 434 PMID: 31511694
Xie et al (2016) Ferroptosis: process and function. Cell Death Differ. 23 369 PMID: 26794443
If you know of a relevant reference for Sulfasalazine, please let us know.
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Keywords: Sulfasalazine, Sulfasalazine supplier, antirheumatic, antiinflammatories, antiinflammatory, arthritis, system, XC, SXC, cysteine-glutamate, antiporters, NF-kappaB, NF-kB, NF-κB, inhibitors, inhibits, ferroptosis, inducers, induces, folate, transporter, 1, cGAMP, SLC19A1, NF-kB/IkB, Ferroptosis, Other, Ion, Pumps/Transporters, 4935, Tocris Bioscience
2 Citations for Sulfasalazine
Citations are publications that use Tocris products. Selected citations for Sulfasalazine include:
Shin et al (2018) Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo. Oncogenesis 7 86 PMID: 30425240
Yeligar et al (2009) Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol 183 5964 PMID: 19828633
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