You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Selective inhibitor of TANK-binding kinase 1 (TBK1) and IKKε (IC50 values are ~1-2 μM). Displays no effect on IKKα or IKKβ at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 298.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.35 mL||16.76 mL||33.52 mL|
|5 mM||0.67 mL||3.35 mL||6.7 mL|
|10 mM||0.34 mL||1.68 mL||3.35 mL|
|50 mM||0.07 mL||0.34 mL||0.67 mL|
References are publications that support the biological activity of the product.
Reilly et al (2012) An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice. Nat.Med. 19 313 PMID: 23396211
Okada et al (2003) Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amle. Biochem.J. 374 433 PMID: 12803546
Makino et al (1987) Mechanism of action of an antiallergic agent, amle. (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase. Int.Arch.Allergy Appl.Immunol. 82 66 PMID: 2433225
If you know of a relevant reference for Amlexanox, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Amlexanox, Amlexanox supplier, diabetes, obese, obesity, mouse, mice, anti-inflammatory, anti-inflammatories, metabolic, disorders, diseases, IkB, kinase, IkappaB, IκB, IKK, TBK1, TANK-binding, 1, noncanonical, Kinase, NF-kB/IkB, Histaminergic-Related, Compounds, TANK, binding, (TBK), 4857, Tocris Bioscience
1 Citation for Amlexanox
Citations are publications that use Tocris products. Selected citations for Amlexanox include:
Alrahbeni et al (2015) Full UPF3B function is critical for neuronal differentiation of neural stem cells. Br J Pharmacol 8 33 PMID: 26012578
Do you know of a great paper that uses Amlexanox from Tocris? Please let us know.
Reviews for Amlexanox
There are currently no reviews for this product. Be the first to review Amlexanox and earn rewards!
Have you used Amlexanox?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.