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Description: High affinity antagonist of RAGE
Chemical Name: 4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide
Purity: ≥99% (HPLC)
Citations (3)
Reviews (1)
Literature (3)

Biological Activity for FPS ZM1

FPS ZM1 is a high affinity antagonist of the receptor for advanced glycation end products (RAGE) (Ki = 25 nM). Blocks Aβ binding to the V domain of RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo. Blocks β-secretase activity, Aβ production, microglia activation and neuroinflammation in vivo. BBB permeable.

Compound Libraries for FPS ZM1

FPS ZM1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for FPS ZM1

M. Wt 327.85
Formula C20H22ClNO
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 945714-67-0
PubChem ID 24752728
Smiles ClC1=CC=C(C(N(C2CCCCC2)CC3=CC=CC=C3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FPS ZM1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.78 100
ethanol 32.78 100

Preparing Stock Solutions for FPS ZM1

The following data is based on the product molecular weight 327.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.25 mL 30.5 mL
5 mM 0.61 mL 3.05 mL 6.1 mL
10 mM 0.31 mL 1.53 mL 3.05 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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References for FPS ZM1

References are publications that support the biological activity of the product.

Deane et al (2012) A multimodal RAGE-specific inhibitor reduces amyloid beta -mediated brain disorder in a mouse model of Alzheimer disease. J.Clin.Invest. 122 1377 PMID: 22406537

Hong et al (2016) Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-beta Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus. Neurochem.Res. 41 1192 PMID: 26738988

If you know of a relevant reference for FPS ZM1, please let us know.

View Related Products by Product Action

View all RAGE Antagonists

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3 Citations for FPS ZM1

Citations are publications that use Tocris products. Selected citations for FPS ZM1 include:

Uderhardt et al (2019) Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 177 541 PMID: 30955887

Hui et al (2021) Proof-of-concept study investigating the role of S100P-RAGE in nasopharyngeal carcinoma. Exp Ther Med 21 470 PMID: 33767765

Venkat et al (2021) S100B Inhibition Attenuates Intestinal Damage and Diarrhea Severity During Clostridioides difficile Infection by Modulating Inflammatory Response. Front Cell Infect Microbiol 11 739874 PMID: 34568098

Do you know of a great paper that uses FPS ZM1 from Tocris? Please let us know.

Reviews for FPS ZM1

Average Rating: 5 (Based on 1 Review.)

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Good inhibitor.
By Anonymous on 06/06/2020
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: phagocyte

DMSO dilution 10 μM

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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