FPS ZM1

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Cat.No. 6237 - FPS ZM1 | C20H22ClNO | CAS No. 945714-67-0
Description: High affinity antagonist of RAGE
Chemical Name: 4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity antagonist of the receptor for advanced glycation end products (RAGE) (Ki = 25 nM). Blocks Aβ binding to the V domain of RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo. Blocks β-secretase activity, Aβ production, microglia activation and neuroinflammation in vivo. BBB permeable.

Technical Data

M. Wt 327.85
Formula C20H22ClNO
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 945714-67-0
PubChem ID 24752728
InChI Key XDFKWGIBQMHSOH-UHFFFAOYSA-N
Smiles ClC1=CC=C(C(N(C2CCCCC2)CC3=CC=CC=C3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.78 100
ethanol 32.78 100

Preparing Stock Solutions

The following data is based on the product molecular weight 327.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.25 mL 30.5 mL
5 mM 0.61 mL 3.05 mL 6.1 mL
10 mM 0.31 mL 1.53 mL 3.05 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Deane et al (2012) A multimodal RAGE-specific inhibitor reduces amyloid beta -mediated brain disorder in a mouse model of Alzheimer disease. J.Clin.Invest. 122 1377 PMID: 22406537

Hong et al (2016) Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-beta Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus. Neurochem.Res. 41 1192 PMID: 26738988


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View all RAGE Antagonists

Keywords: FPS ZM1, supplier, FPSZM1, Inhibitors, Inhibits, Antagonist, RAGE, Receptor, for, advanced, glycation, end, products, RAP, RAGE, antagonist, peptide, blood-brain, barrier, BBB, permeable, penetrant, AB42, Aβ, Aβ42, Alzheimer's, Disease, NF-kB/IkB, RAGE, RAGE, Tocris Bioscience

Citations for FPS ZM1

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