Celastrol

Pricing Availability Delivery Time Qty
Cat.No. 3203 - Celastrol | C29H38O4 | CAS No. 34157-83-0
Description: Inhibits TNF-α-induced NF-κB activation
Chemical Name: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature
Pathways

Biological Activity

Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-α-induced NFκB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 μM).

Technical Data

M. Wt 450.61
Formula C29H38O4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 34157-83-0
PubChem ID 122724
InChI Key KQJSQWZMSAGSHN-JJWQIEBTSA-N
Smiles O=C2C(O)=C(C)C1=CC=C([C@](CC[C@]5(C)[C@]([H])4C[C@](C)([C@@](O)=O)CC5)(C)[C@@]4(C)CC3)[C@]3(C)C1=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.06 100
ethanol 33.8 75

Preparing Stock Solutions

The following data is based on the product molecular weight 450.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.1 mL 22.19 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Nagase et al (2003) Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol. Biosci.Biotechnol.Biochem. 67 1883 PMID: 14519971

Sethi et al (2007) Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation. Blood 109 2727 PMID: 17110449

Sassa et al (1990) The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem.Biophys.Res.Comms. 172 890 PMID:


If you know of a relevant reference for Celastrol, please let us know.

View Related Products by Product Action

View all NF-κB and IκB Inhibitors

Keywords: inhibitors inhibits TNF-α TNF-alpha-induced NF-κB NF-kappaB NF-kB activation Antioxidant anti-inflammatory Topoisomerase II Nuclear Factor Kappa B Cytokine Signaling Signalling Transcription Factors DNA Isomerases NF-kB/IkB

1 Citation for Celastrol

Citations are publications that use Tocris products. Selected citations for Celastrol include:

Zwicker et al (2015) Interleukin 34: a new modulator of human and experimental inflammatory bowel disease. Clin Sci (Lond) 129 281 PMID: 25896238


Do you know of a great paper that uses Celastrol from Tocris? If so please let us know.

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Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Pathways for Celastrol

NF-κB

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.

Protocols

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