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Biological Activity for IP7e
IP7e is a potent Nurr1 activator (EC50 = 3.9 nM). Delays onset and reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). Also suppresses NF-κB signaling. Brain penetrant and orally bioavailable.
Compound Libraries for IP7e
Technical Data for IP7e
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for IP7e
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||7.81||20 with gentle warming|
Preparing Stock Solutions for IP7e
The following data is based on the product molecular weight 390.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.56 mL||12.81 mL||25.61 mL|
|5 mM||0.51 mL||2.56 mL||5.12 mL|
|10 mM||0.26 mL||1.28 mL||2.56 mL|
|50 mM||0.05 mL||0.26 mL||0.51 mL|
References for IP7e
References are publications that support the biological activity of the product.
Hintermann et al (2007) Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg.Med.Chem.Lett. 17 193 PMID: 17035009
Montarolo et al (2014) Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One 9 e108791 PMID: 25265488
If you know of a relevant reference for IP7e, please let us know.
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Citations for IP7e
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Literature in this Area
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