IP7e

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Cat.No. 5699 - IP7e | C23H22N2O4 | CAS No. 500164-74-9
Description: Potent Nurr1 activator
Chemical Name: 6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent Nurr1 activator (EC50 = 3.9 nM). Delays onset and reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). Also suppresses NF-κB signaling. Brain penetrant and orally bioavailable.

Technical Data

M. Wt 390.43
Formula C23H22N2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 500164-74-9
PubChem ID 9908426
InChI Key YCAACZFPADQMAR-UHFFFAOYSA-N
Smiles CN1C(C2=CC=C(COCCOC)C=C2)=CC3=C(C(C4=CC=CC=C4)=NO3)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.04 100
ethanol 7.81 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 390.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.81 mL 25.61 mL
5 mM 0.51 mL 2.56 mL 5.12 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hintermann et al (2007) Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg.Med.Chem.Lett. 17 193 PMID: 17035009

Montarolo et al (2014) Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One 9 e108791 PMID: 25265488


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Keywords: potent Nurr1 activators activates orally bioavailable multiple sclerosis MS EAE experimental autoimmune encephalomyelitis brain penetrant NF-KB κ signaling isoxazolo-pyridinone 7e Other Nuclear Receptors

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