You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent Nurr1 activator (EC50 = 3.9 nM). Delays onset and reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). Also suppresses NF-κB signaling. Brain penetrant and orally bioavailable.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||7.81||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 390.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.56 mL||12.81 mL||25.61 mL|
|5 mM||0.51 mL||2.56 mL||5.12 mL|
|10 mM||0.26 mL||1.28 mL||2.56 mL|
|50 mM||0.05 mL||0.26 mL||0.51 mL|
References are publications that support the biological activity of the product.
Hintermann et al (2007) Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg.Med.Chem.Lett. 17 193 PMID: 17035009
Montarolo et al (2014) Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One 9 e108791 PMID: 25265488
If you know of a relevant reference for IP7e, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: IP7e, IP7e supplier, potent, Nurr1, activators, activates, orally, bioavailable, multiple, sclerosis, MS, EAE, experimental, autoimmune, encephalomyelitis, brain, penetrant, NF-KB, κ, signaling, isoxazolo-pyridinone, 7e, NF-kB/IkB, Nerve, Growth, Factor, IB-like, Receptors, 5699, Tocris Bioscience
Citations for IP7e
Citations are publications that use Tocris products.
Currently there are no citations for IP7e. Do you know of a great paper that uses IP7e from Tocris? Please let us know.
Reviews for IP7e
There are currently no reviews for this product. Be the first to review IP7e and earn rewards!
Have you used IP7e?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Foundations of Immuno-oncology eBook
In this eBook, we examine the complexity of the tumor microenvironment, explore technologies that are innovating basic and translational research, and strategies that are advancing immunotherapy into the clinic.
- Tumor Microenvironment
- Immune Checkpoints
- Therapeutic Monoclonal Antibodies
- Small Molecules & Immuno-Oncology
- Cell-based Therapeutics
- Cytokines and Immunotherapy
- Tools to Advance Your Immuno-Oncology Research