You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo. Prevents NF-κB activation by inhibiting activation of IKKβ. Also inhibits chymotrypsin-like activity of the 20S proteasome.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 470.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||21.25 mL||106.25 mL||212.49 mL|
|0.5 mM||4.25 mL||21.25 mL||42.5 mL|
|1 mM||2.12 mL||10.62 mL||21.25 mL|
|5 mM||0.42 mL||2.12 mL||4.25 mL|
References are publications that support the biological activity of the product.
Mohan et al (2004) Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis 7 115 PMID: 15516832
Yang et al (2007) The tumor proteasome is a primary target for the natural anticancer compound withaferin A isolated from "Indian Winter Cherry". Mol.Pharmacol. 71 426 PMID: 17093135
Kaileh et al (2007) Withaferin A strongly elicits IkB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity. J.Biol.Chem. 282 4253 PMID: 17150968
If you know of a relevant reference for Withaferin A, please let us know.
View Related Products by Product Action
Keywords: Withaferin A, Withaferin A supplier, inhibitors, inhibits, NF-κB, NF-kappaB, NF-kB, activation, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Transcription, Factors, WithaferinA, NF-kB/IkB, 2816, Tocris Bioscience
5 Citations for Withaferin A
Citations are publications that use Tocris products. Selected citations for Withaferin A include:
Yang et al (2016) The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Neural Plast 7 11385 PMID: 27150562
Martorana et al (2015) Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes. EMBO J 2015 381964 PMID: 26266054
Hatzold et al (2016) Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit. Elife 5 PMID: 27240166
Trendelenburg et al (2012) TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of AVNA. Skelet Muscle 2 3 PMID: 22313861
Yadav et al (2010) Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor. J Mol Med (Berl) 88 1243 PMID: 20798912
Do you know of a great paper that uses Withaferin A from Tocris? Please let us know.
Reviews for Withaferin A
Average Rating: 5 (Based on 1 Review.)
Have you used Withaferin A?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
RAW macrophages were stimulated with Withaferin (1 µM) alone or in the presence of LPS (200 ng/ml) for 8 h to follow TNFalpha mRNA expression using qPCR. Withaferin significantly inhibited LPS-induced TNFalpha production.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.