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Description: Potent NIK inhibitor
Chemical Name: 4-[3-[2-Amino-5-(2-methoxyethoxy)-4-pyrimidinyl]-1H-indol-5-yl]-2-methyl-3-butyn-2-ol
Purity: ≥98%
Pathways (1)

Biological Activity for NIKi

NIKi is a potent inhibitor of NF-κB-inducing kinase (NIK) activity (IC50 = 20 nM).

Technical Data for NIKi

M. Wt 366.42
Formula C20H22N4O3
Storage Store at -20°C
Purity ≥98%
CAS Number 1202763-91-4
PubChem ID 58221375
Smiles COCCOC1=CN=C(N=C1C2=CNC3=CC=C(C#CC(C)(O)C)C=C23)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NIKi

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.64 100

Preparing Stock Solutions for NIKi

The following data is based on the product molecular weight 366.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.65 mL 27.29 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.36 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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References for NIKi

References are publications that support the biological activity of the product.

Li et al (2013) Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures. Bioorg.Med.Chem.Lett. 23 1238 PMID: 23374866

If you know of a relevant reference for NIKi, please let us know.

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Keywords: NIKi, NIKi supplier, potent, NF-κB, nf-kappab, nf-κb, blocks, inhibitors, inhibits, nuclear, factor, kappa, B, anti-inflammatory, antitumor, antitumour, NF-kB/IkB, 7136, Tocris Bioscience

Citations for NIKi

Citations are publications that use Tocris products.

Currently there are no citations for NIKi. Do you know of a great paper that uses NIKi from Tocris? Please let us know.

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Pathways for NIKi

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.