RAGE antagonist peptide

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Cat.No. 6259 - RAGE antagonist peptide | Ac-Glu-Leu-Lys-Val-Leu-Met-Glu-Lys-Glu-Leu-NH2 | CAS No. 1092460-91-7
Description: RAGE antagonist
Datasheet
Citations
Literature

Biological Activity

Receptor for advanced glycation end products (RAGE) antagonist. Blocks S100P, S100A4 and HMGB-1 mediated RAGE activation in vitro and in vivo. Inhibits growth and metastasis of rat glioma tumors. Reduces cell growth and RAGE-mediated NF-κB activity in human PDAC cell lines. Inhibits effects of TDI exposure in BALB/c mice.

Technical Data

M. Wt 1272.56
Formula C57H101N13O17S
Sequence ELKVLMEKEL

(Modifications: Glu-1 = N-terminal Ac, Leu-10 = C-terminal amide)

Storage Store at -20°C
CAS Number 1092460-91-7
PubChem ID 127021052
InChI Key UPCWJIBXKJZZLN-YZLORNOTNA-N
Smiles CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1272.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.79 mL 3.93 mL 7.86 mL
5 mM 0.16 mL 0.79 mL 1.57 mL
10 mM 0.08 mL 0.39 mL 0.79 mL
50 mM 0.02 mL 0.08 mL 0.16 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Arumugam et al (2012) S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin.Cancer.Res. 18 4356 PMID: 2718861

Yao et al (2016) The receptor for advanced glycation end products is required for beta -catenin stabilization in a chemical-induced asthma model. Br.J.Pharmacol. 173 2600 PMID: 7332707


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Keywords: RAGE antagonist peptide, supplier, Inhibitors, Inhibits, Antagonist, RAGE, Receptor, for, advanced, glycation, end, products, RAP, RAGE, antagonist, peptide, NF-kB/IkB, RAGE, RAGE, Tocris Bioscience

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