RAGE antagonist peptide

Pricing Availability   Qty
Description: RAGE antagonist
Purity: ≥95% (HPLC)
Citations (2)
Reviews (1)
Literature (3)

Biological Activity for RAGE antagonist peptide

RAGE antagonist peptide is a receptor for advanced glycation end products (RAGE) antagonist. Blocks S100P, S100A4 and HMGB-1 mediated RAGE activation in vitro and in vivo. Inhibits growth and metastasis of rat glioma tumors. Reduces cell growth and RAGE-mediated NF-κB activity in human PDAC cell lines. Inhibits effects of TDI exposure in BALB/c mice.

Technical Data for RAGE antagonist peptide

M. Wt 1272.56
Formula C57H101N13O17S

(Modifications: Glu-1 = N-terminal Ac, Leu-10 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1092460-91-7
PubChem ID 127021052
Smiles CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RAGE antagonist peptide

Solubility Soluble to 1 mg/ml in water

Product Datasheets for RAGE antagonist peptide

Certificate of Analysis / Product Datasheet
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References for RAGE antagonist peptide

References are publications that support the biological activity of the product.

Arumugam et al (2012) S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin.Cancer.Res. 18 4356 PMID: 22718861

Yao et al (2016) The receptor for advanced glycation end products is required for beta -catenin stabilization in a chemical-induced asthma model. Br.J.Pharmacol. 173 2600 PMID: 27332707

If you know of a relevant reference for RAGE antagonist peptide, please let us know.

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Keywords: RAGE antagonist peptide, RAGE antagonist peptide supplier, Inhibitors, Inhibits, Antagonist, RAGE, Receptor, for, advanced, glycation, end, products, RAP, antagonist, peptide, NF-kB/IkB, 6259, Tocris Bioscience

2 Citations for RAGE antagonist peptide

Citations are publications that use Tocris products. Selected citations for RAGE antagonist peptide include:

Uderhardt et al (2019) Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 177 541 PMID: 30955887

Thom et al (2023) Blood-Borne Microparticles Are an Inflammatory Stimulus in Type 2 Diabetes Mellitus Immunohorizons 7 71 PMID: 36645851

Do you know of a great paper that uses RAGE antagonist peptide from Tocris? Please let us know.

Reviews for RAGE antagonist peptide

Average Rating: 5 (Based on 1 Review.)

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Good inhibitor.
By Stefan Uderhardt on 06/06/2020
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: phagocyte

H20 dilution 10 μM

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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