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Biological Activity for RAGE antagonist peptide
RAGE antagonist peptide is a receptor for advanced glycation end products (RAGE) antagonist. Blocks S100P, S100A4 and HMGB-1 mediated RAGE activation in vitro and in vivo. Inhibits growth and metastasis of rat glioma tumors. Reduces cell growth and RAGE-mediated NF-κB activity in human PDAC cell lines. Inhibits effects of TDI exposure in BALB/c mice.
Technical Data for RAGE antagonist peptide
(Modifications: Glu-1 = N-terminal Ac, Leu-10 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RAGE antagonist peptide
|Solubility||Soluble to 1 mg/ml in water|
Product Datasheets for RAGE antagonist peptide
References for RAGE antagonist peptide
References are publications that support the biological activity of the product.
Arumugam et al (2012) S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin.Cancer.Res. 18 4356 PMID: 22718861
Yao et al (2016) The receptor for advanced glycation end products is required for beta -catenin stabilization in a chemical-induced asthma model. Br.J.Pharmacol. 173 2600 PMID: 27332707
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2 Citations for RAGE antagonist peptide
Citations are publications that use Tocris products. Selected citations for RAGE antagonist peptide include:
Uderhardt et al (2019) Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 177 541 PMID: 30955887
Thom et al (2023) Blood-Borne Microparticles Are an Inflammatory Stimulus in Type 2 Diabetes Mellitus Immunohorizons 7 71 PMID: 36645851
Do you know of a great paper that uses RAGE antagonist peptide from Tocris? Please let us know.
Reviews for RAGE antagonist peptide
Average Rating: 5 (Based on 1 Review.)
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H20 dilution 10 μM
Literature in this Area
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