ACHP

Pricing Availability Delivery Time Qty
Cat.No. 4547 - ACHP | C21H24N4O2 | CAS No. 406208-42-2
Description: Selective IKKα and IKKβ inhibitor
Chemical Name: 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

IκB kinase inhibitor (IC50 values are 8.5 and 250 nM for IKKβ and IKKα respectively). Selective for IKKα and IKKβ over IKK3, Syk and MAPKKK4 (IC50 values are > 20 μM). Inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis.

Technical Data

M. Wt 364.44
Formula C21H24N4O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 406208-42-2
PubChem ID 65663
InChI Key SRVFFFJZQVENJC-IHRRRGAJSA-N
Smiles OC1=CC=CC(OCC3CC3)=C1C2=NC(N)=C(C#N)C(C4CCNCC4)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.29 20

Preparing Stock Solutions

The following data is based on the product molecular weight 364.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Sanda et al (2005) Growth inhibition of multiple myeloma cells by a novel IκB kinase inhibitor. Clin.Cancer Res. 11 1974 PMID: 15756023


If you know of a relevant reference for ACHP, please let us know.

View Related Products by Product Action

View all IκB Kinase Inhibitors

Keywords: ACHP, supplier, IkappaB, IKB, kinase, IKKalpha, IKKa, IKKbeta, IKKb, inhibitors, inhibits, NF-kB, pathway, apoptosis, inducers, cell, growth, arrest, anticancer, IkB, Kinase, Tocris Bioscience

2 Citations for ACHP

Citations are publications that use Tocris products. Selected citations for ACHP include:

Mbongue et al (2015) Induction of indoleamine 2, 3-dioxygenase in human dendritic cells by a cholera toxin B subunit-proinsulin vaccine. Front Cell Neurosci 10 e0118562 PMID: 25714914

Mia and Bank (2015) The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis. J Cell Mol Med PMID: 26337045


Do you know of a great paper that uses ACHP from Tocris? If so please let us know.

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Reviews

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Literature in this Area

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Pathways for ACHP

Protocols

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