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Chalone analog that display anti-inflammatory activity. Inhibits NO and PGE2 production from LPS- and IFN-γ-induced RAW cells and inhibits TXB2 production via the COX-1 and COX-2 pathways. Inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 270.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.7 mL||18.5 mL||37 mL|
|5 mM||0.74 mL||3.7 mL||7.4 mL|
|10 mM||0.37 mL||1.85 mL||3.7 mL|
|50 mM||0.07 mL||0.37 mL||0.74 mL|
References are publications that support the biological activity of the product.
Lee et al (2006) Blockade of nuclear factor-κB signaling pathway and anti-inflammatory activity of Cardamomin, a chalcone analog from Alpina conchigera. J.Pharmacol.Exp.Ther. 316 271 PMID: 16183703
Ahmad et al (2006) Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood. Eur.J.Pharmacol. 538 188 PMID: 16650843
Israf et al (2007) Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-κB nuclear translocation and Iκ-B phosphorylation in RAW 264.7 macrophage cells. Mol.Immunol. 44 673 PMID: 16777230
If you know of a relevant reference for Cardamonin, please let us know.
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Keywords: Cardamonin, Cardamonin supplier, Nf-kappaB, NF-kB, NF-κB, inhibitors, activation, inhibits, anti-inflammatory, transcription, factors, nuclear, factor, kappa, B, signaling, signalling, NF-kB/IkB, 2509, Tocris Bioscience
3 Citations for Cardamonin
Citations are publications that use Tocris products. Selected citations for Cardamonin include:
Yadav et al (2012) Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins. Br J Pharmacol 165 741 PMID: 21797841
Jia et al (2015) β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer. Cell Death Differ 22 298 PMID: 25257174
Kim et al (2016) Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks. EBioMedicine 7 100 PMID: 27322464
Do you know of a great paper that uses Cardamonin from Tocris? Please let us know.
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Literature in this Area
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