Cardamonin

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Cat.No. 2509 - Cardamonin | C16H14O4 | CAS No. 19309-14-9
Description: Inhibitor of NF-κB activation; anti-inflammatory
Chemical Name: (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature
Pathways

Biological Activity

Chalone analog that display anti-inflammatory activity. Inhibits NO and PGE2 production from LPS- and IFN-γ-induced RAW cells and inhibits TXB2 production via the COX-1 and COX-2 pathways. Inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.

Technical Data

M. Wt 270.28
Formula C16H14O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 19309-14-9
PubChem ID 641785
InChI Key NYSZJNUIVUBQMM-BQYQJAHWSA-N
Smiles OC1=CC(O)=C(C(/C=C/C2=CC=CC=C2)=O)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.03 100
ethanol 5.41 20

Preparing Stock Solutions

The following data is based on the product molecular weight 270.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.7 mL 18.5 mL 37 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
10 mM 0.37 mL 1.85 mL 3.7 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lee et al (2006) Blockade of nuclear factor-κB signaling pathway and anti-inflammatory activity of Cardamomin, a chalcone analog from Alpina conchigera. J.Pharmacol.Exp.Ther. 316 271 PMID: 16183703

Ahmad et al (2006) Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood. Eur.J.Pharmacol. 538 188 PMID: 16650843

Israf et al (2007) Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-κB nuclear translocation and Iκ-B phosphorylation in RAW 264.7 macrophage cells. Mol.Immunol. 44 673 PMID: 16777230


If you know of a relevant reference for Cardamonin, please let us know.

View Related Products by Product Action

View all NF-κB and IκB Inhibitors

Keywords: Cardamonin, supplier, Nf-kappaB, NF-kB, NF-κB, inhibitors, activation, inhibits, anti-inflammatory, transcription, factors, nuclear, factor, kappa, B, signaling, signalling, NF-kB/IkB, NF-kB/IkB, Tocris Bioscience

2 Citations for Cardamonin

Citations are publications that use Tocris products. Selected citations for Cardamonin include:

Yadav et al (2012) Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins. Br J Pharmacol 165 741 PMID: 21797841

Jia et al (2015) β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer. Cell Death Differ 22 298 PMID: 25257174


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Pathways for Cardamonin

NF-κB

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.