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Description: Inhibitor of NF-κB activation; anti-inflammatory
Chemical Name: (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one
Purity: ≥98% (HPLC)
Citations (3)
Pathways (1)

Biological Activity for Cardamonin

Cardamonin is a chalone analog that display anti-inflammatory activity. Inhibits NO and PGE2 production from LPS- and IFN-γ-induced RAW cells and inhibits TXB2 production via the COX-1 and COX-2 pathways. Inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.

Compound Libraries for Cardamonin

Cardamonin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Cardamonin

M. Wt 270.28
Formula C16H14O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 19309-14-9
PubChem ID 641785
Smiles OC1=CC(O)=C(C(/C=C/C2=CC=CC=C2)=O)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cardamonin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.03 100
ethanol 5.41 20

Preparing Stock Solutions for Cardamonin

The following data is based on the product molecular weight 270.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.7 mL 18.5 mL 37 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
10 mM 0.37 mL 1.85 mL 3.7 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets for Cardamonin

Certificate of Analysis / Product Datasheet
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References for Cardamonin

References are publications that support the biological activity of the product.

Lee et al (2006) Blockade of nuclear factor-κB signaling pathway and anti-inflammatory activity of Cardamomin, a chalcone analog from Alpina conchigera. J.Pharmacol.Exp.Ther. 316 271 PMID: 16183703

Ahmad et al (2006) Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood. Eur.J.Pharmacol. 538 188 PMID: 16650843

Israf et al (2007) Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-κB nuclear translocation and Iκ-B phosphorylation in RAW 264.7 macrophage cells. Mol.Immunol. 44 673 PMID: 16777230

If you know of a relevant reference for Cardamonin, please let us know.

View Related Products by Product Action

View all NF-κB and IκB Inhibitors

Keywords: Cardamonin, Cardamonin supplier, Nf-kappaB, NF-kB, NF-κB, inhibitors, activation, inhibits, anti-inflammatory, transcription, factors, nuclear, factor, kappa, B, signaling, signalling, NF-kB/IkB, 2509, Tocris Bioscience

3 Citations for Cardamonin

Citations are publications that use Tocris products. Selected citations for Cardamonin include:

Jia et al (2015) β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer. Cell Death Differ 22 298 PMID: 25257174

Yadav et al (2012) Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins. Br J Pharmacol 165 741 PMID: 21797841

Kim et al (2016) Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks. EBioMedicine 7 100 PMID: 27322464

Do you know of a great paper that uses Cardamonin from Tocris? Please let us know.

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Pathways for Cardamonin

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.