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Anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activation. Also inhibits TNF-α -induced COX-2 expression. Antiproliferative and chemopreventative; inhibits proliferation of Lewis lung carcinoma cells in vivo. Inhibits influenza virus replication in vitro by preventing viral entry. Molecular docking studies also indicate binding to SARS-CoV-2 main protease (Mpro or 3CLpro).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 286.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.99 mL||34.94 mL||69.87 mL|
|2.5 mM||1.4 mL||6.99 mL||13.97 mL|
|5 mM||0.7 mL||3.49 mL||6.99 mL|
|25 mM||0.14 mL||0.7 mL||1.4 mL|
References are publications that support the biological activity of the product.
Ju et al (2007) A critical role of luteolin-induced reactive oxygen species in blockage of tumour necrosis factor-activated nuclear factor-κB pathway and sensitization of apoptosis in lung cancer cells. Mol.Pharmacol. 71 1381 PMID: 17296806
Chen et al (2007) Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophage. Life Sci. 81 1602 PMID: 17977562
Kim et al (2007) Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells. Ann.N.Y.Acad.Sci. 1090 597
Kim et al (2011) Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/ threonine kinase, inhibits tumor necrosis factor-α-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells. J.Pharm.Exp.Ther. 338 1013
Yan et al (2019) Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression. J.Nat.Med. 73 487 PMID: 30758716
Yu et al (2020) Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking. Int.J.Antimicrob.Agents PMID: 32389723
If you know of a relevant reference for Luteolin, please let us know.
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Keywords: Luteolin, Luteolin supplier, Anti-inflammatory, antioxidant, free, radical, scavengers, NF-kB, NF-kappaB, NF-κB, inhibitors, inhibits, blocks, activation, antivirals, influenza, virus, COVID-19, SARS-CoV-2, main, protease, 3CLpro, 3',4',5,7-Tetrahydroxyflavone, Antioxidants, NF-kB/IkB, 2874, Tocris Bioscience
2 Citations for Luteolin
Citations are publications that use Tocris products. Selected citations for Luteolin include:
Cook et al (2015) Luteolin inhibits progestin-dependent angiogenesis, stem cell-like characteristics, and growth of human breast cancer xenografts. Springerplus 4 444 PMID: 26312209
Cook et al (2017) Luteolin inhibits lung metastasis, cell migration, and viability of triple-negative breast cancer cells. Breast Cancer (Dove Med Press) 9 9 PMID: 28096694
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Literature in this Area
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