Luteolin

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Cat.No. 2874 - Luteolin | C15H10O6 | CAS No. 491-70-3
Description: Anti-inflammatory, antioxidant and free radical scavenger
Alternative Names: 3',4',5,7-Tetrahydroxyflavone
Chemical Name: 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activation. Also inhibits TNF-α -induced COX-2 expression. Antiproliferative and chemopreventative; inhibits proliferation of Lewis lung carcinoma cells in vivo.

Technical Data

M. Wt 286.24
Formula C15H10O6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 491-70-3
PubChem ID 5280445
InChI Key IQPNAANSBPBGFQ-UHFFFAOYSA-N
Smiles O=C(C=C(C3=CC(O)=C(O)C=C3)O2)C1=C2C=C(O)C=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 1.43 5
DMSO 14.31 50

Preparing Stock Solutions

The following data is based on the product molecular weight 286.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.99 mL 34.94 mL 69.87 mL
2.5 mM 1.4 mL 6.99 mL 13.97 mL
5 mM 0.7 mL 3.49 mL 6.99 mL
25 mM 0.14 mL 0.7 mL 1.4 mL

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References

References are publications that support the biological activity of the product.

Ju et al (2007) A critical role of luteolin-induced reactive oxygen species in blockage of tumour necrosis factor-activated nuclear factor-κB pathway and sensitization of apoptosis in lung cancer cells. Mol.Pharmacol. 71 1381 PMID: 17296806

Chen et al (2007) Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophage. Life Sci. 81 1602 PMID: 17977562

Kim et al (2007) Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells. Ann.N.Y.Acad.Sci. 1090 597

Kim et al (2011) Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/ threonine kinase, inhibits tumor necrosis factor-α-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells. J.Pharm.Exp.Ther. 338 1013


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Keywords: Luteolin, Luteolin supplier, Anti-inflammatory, antioxidant, free, radical, scavengers, NF-kB, NF-kappaB, NF-κB, inhibitors, inhibits, blocks, activation, 3',4',5,7-Tetrahydroxyflavone, Antioxidants, NF-kB/IkB, 2874, Tocris Bioscience

2 Citations for Luteolin

Citations are publications that use Tocris products. Selected citations for Luteolin include:

Cook et al (2015) Luteolin inhibits progestin-dependent angiogenesis, stem cell-like characteristics, and growth of human breast cancer xenografts. Springerplus 4 444 PMID: 26312209

Cook et al (2017) Luteolin inhibits lung metastasis, cell migration, and viability of triple-negative breast cancer cells. Breast Cancer (Dove Med Press) 9 9 PMID: 28096694


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Literature in this Area

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