Luteolin

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Cat.No. 2874 - Luteolin | C15H10O6 | CAS No. 491-70-3
Description: Anti-inflammatory, antioxidant and free radical scavenger
Alternative Names: 3',4',5,7-Tetrahydroxyflavone
Chemical Name: 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews

Biological Activity for Luteolin

Luteolin is an anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activation. Also inhibits TNF-α -induced COX-2 expression. Antiproliferative and chemopreventative; inhibits proliferation of Lewis lung carcinoma cells in vivo. Inhibits influenza virus replication in vitro by preventing viral entry. Molecular docking studies also indicate binding to SARS-CoV-2 main protease (Mpro or 3CLpro).

Technical Data for Luteolin

M. Wt 286.24
Formula C15H10O6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 491-70-3
PubChem ID 5280445
InChI Key IQPNAANSBPBGFQ-UHFFFAOYSA-N
Smiles O=C(C=C(C3=CC(O)=C(O)C=C3)O2)C1=C2C=C(O)C=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Luteolin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 1.43 5
DMSO 14.31 50

Preparing Stock Solutions for Luteolin

The following data is based on the product molecular weight 286.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.99 mL 34.94 mL 69.87 mL
2.5 mM 1.4 mL 6.99 mL 13.97 mL
5 mM 0.7 mL 3.49 mL 6.99 mL
25 mM 0.14 mL 0.7 mL 1.4 mL

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Keywords: Luteolin, Luteolin supplier, Anti-inflammatory, antioxidant, free, radical, scavengers, NF-kB, NF-kappaB, NF-κB, inhibitors, inhibits, blocks, activation, antivirals, influenza, virus, COVID-19, SARS-CoV-2, main, protease, 3CLpro, 3',4',5,7-Tetrahydroxyflavone, Antioxidants, NF-kB/IkB, 2874, Tocris Bioscience

2 Citations for Luteolin

Citations are publications that use Tocris products. Selected citations for Luteolin include:

Cook et al (2015) Luteolin inhibits progestin-dependent angiogenesis, stem cell-like characteristics, and growth of human breast cancer xenografts. Springerplus 4 444 PMID: 26312209

Cook et al (2017) Luteolin inhibits lung metastasis, cell migration, and viability of triple-negative breast cancer cells. Breast Cancer (Dove Med Press) 9 9 PMID: 28096694


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