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Potent and selective IKKε inhibitor (pIC50 = 7.4). Exhibits >100-fold selectivity for IKKε over IKKα IKKβ, and a range of other kinases.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 469.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.13 mL||10.65 mL||21.3 mL|
|5 mM||0.43 mL||2.13 mL||4.26 mL|
|10 mM||0.21 mL||1.06 mL||2.13 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References are publications that support the biological activity of the product.
Bamborough et al (2006) 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase. Bioorg.Med.Chem.Lett. 16 6236 PMID: 16997559
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Keywords: GSK 319347A, GSK 319347A supplier, GSK319347A, potent, selective, IKKepsilon, ε, inhibitor, inhibits, IkB, Kinase, NF-kB/IkB, 5672, Tocris Bioscience
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