GSK 319347A

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Description: Potent and selective IKKε inhibitor
Chemical Name: 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for GSK 319347A

GSK 319347A is a potent and selective IKKε inhibitor (pIC50 = 7.4). Exhibits >100-fold selectivity for IKKε over IKKα IKKβ, and a range of other kinases.

Compound Libraries for GSK 319347A

GSK 319347A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK 319347A

M. Wt 469.53
Formula C22H19N3O5S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 862812-98-4
PubChem ID 11626927
InChI Key LDTAHRLHGHFHKP-UHFFFAOYSA-N
Smiles CS(C1=CC=CC=C1COC2=C(C#N)SC(N3C4=CC(OC)=C(OC)C=C4N=C3)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSK 319347A

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.95 100

Preparing Stock Solutions for GSK 319347A

The following data is based on the product molecular weight 469.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL
10 mM 0.21 mL 1.06 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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References for GSK 319347A

References are publications that support the biological activity of the product.

Bamborough et al (2006) 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase. Bioorg.Med.Chem.Lett. 16 6236 PMID: 16997559


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Keywords: GSK 319347A, GSK 319347A supplier, GSK319347A, potent, selective, IKKepsilon, ε, inhibitor, inhibits, IkB, Kinase, NF-kB/IkB, 5672, Tocris Bioscience

1 Citation for GSK 319347A

Citations are publications that use Tocris products. Selected citations for GSK 319347A include:

Mina J et al (2022) The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings. Mol Oncol 16 130-147 PMID: 34058066


Do you know of a great paper that uses GSK 319347A from Tocris? Please let us know.

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