GSK 319347A

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Potent and selective IKKε inhibitor
Chemical Name: 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for GSK 319347A

GSK 319347A is a potent and selective IKKε inhibitor (pIC50 = 7.4). Exhibits >100-fold selectivity for IKKε over IKKα IKKβ, and a range of other kinases.

Compound Libraries for GSK 319347A

GSK 319347A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK 319347A

M. Wt 469.53
Formula C22H19N3O5S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 862812-98-4
PubChem ID 11626927
Smiles CS(C1=CC=CC=C1COC2=C(C#N)SC(N3C4=CC(OC)=C(OC)C=C4N=C3)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSK 319347A

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.95 100

Preparing Stock Solutions for GSK 319347A

The following data is based on the product molecular weight 469.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL
10 mM 0.21 mL 1.06 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for GSK 319347A

References are publications that support the biological activity of the product.

Bamborough et al (2006) 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase. Bioorg.Med.Chem.Lett. 16 6236 PMID: 16997559

If you know of a relevant reference for GSK 319347A, please let us know.

View Related Products by Product Action

View all IκB Kinase Inhibitors

Keywords: GSK 319347A, GSK 319347A supplier, GSK319347A, potent, selective, IKKepsilon, ε, inhibitor, inhibits, IkB, Kinase, NF-kB/IkB, 5672, Tocris Bioscience

1 Citation for GSK 319347A

Citations are publications that use Tocris products. Selected citations for GSK 319347A include:

Mina J et al (2022) The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings. Mol Oncol 16 130-147 PMID: 34058066

Do you know of a great paper that uses GSK 319347A from Tocris? Please let us know.

Reviews for GSK 319347A

There are currently no reviews for this product. Be the first to review GSK 319347A and earn rewards!

Have you used GSK 319347A?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review