C-DIM 12

Pricing Availability Delivery Time Qty
Cat.No. 5821 - C-DIM 12 | C23H17ClN2 | CAS No. 178946-89-9
Description: Nurr1 activator; inhibits NF-κB-dependent gene expression
Chemical Name: 3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole]
Purity: ≥98% (HPLC)

Biological Activity

Nurr1 activator. Inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. Neuroprotective in a mouse Parkinson's disease model. Orally bioavailable.

Technical Data

M. Wt 356.85
Formula C23H17ClN2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 178946-89-9
PubChem ID 5302583
Smiles ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.69 100
ethanol 35.69 100

Preparing Stock Solutions

The following data is based on the product molecular weight 356.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.8 mL 14.01 mL 28.02 mL
5 mM 0.56 mL 2.8 mL 5.6 mL
10 mM 0.28 mL 1.4 mL 2.8 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

De Miranda et al (2013) Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease. J.Pharmacol.Exp.Ther. 345 125 PMID: 23318470

De Miranda et al (2015) The Nurr1 activator 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane blocks inflammatory gene expression in BV-2 microglial cells by inhibiting nuclear factor κB. Mol Pharmacol. 87 1021 PMID: 25858541

If you know of a relevant reference for C-DIM 12, please let us know.

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