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Submit ReviewC-DIM 12
Description: Nurr1 activator; inhibits NF-κB-dependent gene expression
Chemical Name: 3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole]
Purity: ≥98% (HPLC)
Biological Activity for C-DIM 12
C-DIM 12 is a nurr1 activator. Inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. Neuroprotective in a mouse Parkinson's disease model. Orally bioavailable.
Technical Data for C-DIM 12
| M. Wt | 356.85 |
| Formula | C23H17ClN2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 178946-89-9 |
| PubChem ID | 5302583 |
| InChI Key | LTLRXTDMXOFBDW-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for C-DIM 12
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.69 | 100 | |
| ethanol | 35.69 | 100 |
Preparing Stock Solutions for C-DIM 12
The following data is based on the product molecular weight 356.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.8 mL | 14.01 mL | 28.02 mL |
| 5 mM | 0.56 mL | 2.8 mL | 5.6 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.8 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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Product Datasheets for C-DIM 12
References for C-DIM 12
References are publications that support the biological activity of the product.
De Miranda et al (2013) Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease. J.Pharmacol.Exp.Ther. 345 125 PMID: 23318470
De Miranda et al (2015) The Nurr1 activator 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane blocks inflammatory gene expression in BV-2 microglial cells by inhibiting nuclear factor κB. Mol Pharmacol. 87 1021 PMID: 25858541
If you know of a relevant reference for C-DIM 12, please let us know.
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Keywords: C-DIM 12, C-DIM 12 supplier, C-DIM12, Nurr1, activators, activates, NF-KB, NK-kappaB, NF-κB, signaling, signalling, orally, bioavailable, neuroprotective, neuroinflammation, NF-kB/IkB, Nerve, Growth, Factor, IB-like, Receptors, 5821, Tocris Bioscience
Citations for C-DIM 12
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MAPK Signaling Pathway
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