C-DIM 12

Cat. No. 5821 Submit a Review Datasheet / COA / SDS

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Description: Nurr1 activator; inhibits NF-κB-dependent gene expression

Chemical Name: 3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole]

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Literature (5)

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for C-DIM 12

C-DIM 12 is a nurr1 activator. Inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. Neuroprotective in a mouse Parkinson's disease model. Orally bioavailable.

Technical Data for C-DIM 12

M. Wt	356.85
Formula	C₂₃H₁₇ClN₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	178946-89-9
PubChem ID	5302583
InChI Key	LTLRXTDMXOFBDW-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for C-DIM 12

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.69	100
	ethanol	35.69	100

Preparing Stock Solutions for C-DIM 12

The following data is based on the product molecular weight 356.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.8 mL	14.01 mL	28.02 mL
5 mM	0.56 mL	2.8 mL	5.6 mL
10 mM	0.28 mL	1.4 mL	2.8 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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Product Datasheets for C-DIM 12

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for C-DIM 12

References are publications that support the biological activity of the product.

De Miranda et al (2013) Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease. J.Pharmacol.Exp.Ther. 345 125 PMID: 23318470

De Miranda et al (2015) The Nurr1 activator 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane blocks inflammatory gene expression in BV-2 microglial cells by inhibiting nuclear factor κB. Mol Pharmacol. 87 1021 PMID: 25858541

If you know of a relevant reference for C-DIM 12, please let us know.

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Keywords: C-DIM 12, C-DIM 12 supplier, C-DIM12, Nurr1, activators, activates, NF-KB, NK-kappaB, NF-κB, signaling, signalling, orally, bioavailable, neuroprotective, neuroinflammation, NF-kB/IkB, Nerve, Growth, Factor, IB-like, Receptors, 5821, Tocris Bioscience

Citations for C-DIM 12

Citations are publications that use Tocris products.

Currently there are no citations for C-DIM 12. Do you know of a great paper that uses C-DIM 12 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

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MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for C-DIM 12

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.