C-DIM 12

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Description: Nurr1 activator; inhibits NF-κB-dependent gene expression
Chemical Name: 3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole]
Purity: ≥98% (HPLC)
Literature (1)
Pathways (1)

Biological Activity for C-DIM 12

C-DIM 12 is a nurr1 activator. Inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. Neuroprotective in a mouse Parkinson's disease model. Orally bioavailable.

Technical Data for C-DIM 12

M. Wt 356.85
Formula C23H17ClN2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 178946-89-9
PubChem ID 5302583
Smiles ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for C-DIM 12

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.69 100
ethanol 35.69 100

Preparing Stock Solutions for C-DIM 12

The following data is based on the product molecular weight 356.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.8 mL 14.01 mL 28.02 mL
5 mM 0.56 mL 2.8 mL 5.6 mL
10 mM 0.28 mL 1.4 mL 2.8 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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References for C-DIM 12

References are publications that support the biological activity of the product.

De Miranda et al (2013) Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease. J.Pharmacol.Exp.Ther. 345 125 PMID: 23318470

De Miranda et al (2015) The Nurr1 activator 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane blocks inflammatory gene expression in BV-2 microglial cells by inhibiting nuclear factor κB. Mol Pharmacol. 87 1021 PMID: 25858541

If you know of a relevant reference for C-DIM 12, please let us know.

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Citations for C-DIM 12

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for C-DIM 12

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.
NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.