Bay 11-7821

Pricing Availability Delivery Time Qty
Cat.No. 1744 - Bay 11-7821 | C10H9NO2S | CAS No. 19542-67-7
Description: E2 ubiquitin (Ub) conjugating enzymes inhibitor
Alternative Names: Bay 11-7082
Chemical Name: (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

E2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines. Also inhibits activation of NLRP3 inflammasome.

Technical Data

M. Wt 207.25
Formula C10H9NO2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 19542-67-7
PubChem ID 5353431
InChI Key DOEWDSDBFRHVAP-KRXBUXKQSA-N
Smiles CC1=CC=C(C=C1)S(=O)(=O)\C=C\C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.73 100
ethanol 5.18 25

Preparing Stock Solutions

The following data is based on the product molecular weight 207.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.83 mL 24.13 mL 48.25 mL
5 mM 0.97 mL 4.83 mL 9.65 mL
10 mM 0.48 mL 2.41 mL 4.83 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mori et al (2002) Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 100 1828 PMID: 12176906

Pierce et al (1997) Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 272 21096 PMID: 9261113

Strickson et al (2013) The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem.J. 451 427 PMID: 23441730

Juliana et al (2010) Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J.Biol.Chem. 285 9792 PMID: 20093358


If you know of a relevant reference for Bay 11-7821, please let us know.

View Related Products by Product Action

View all Ubiquitin/Ubl E2 Conjugating Enzyme Inhibitors

Keywords: Bay 11-7821, supplier, Irreversible, inhibitors, inhibits, TNF-α, TNF-alpha-induced, IκB, IκBα, IkappaBalpha, phosphorylation, IkappaB, Nuclear, Factor, Kappa, B, NF-κB, NF-kappaB, and, Cytokine, Signaling, Signalling, Transcription, Factors, Bay11-7821, Bay117082, NF-kB, NLRP3, Bay, 11-7082, NF-kB/IkB, Post-translational, Modifications, Ubiquitin/Ubl, E2, Conjugating, Enzymes, Inflammasomes, Ubiquitin/Ubl, E2, Conjugating, Enzymes, Tocris Bioscience

4 Citations for Bay 11-7821

Citations are publications that use Tocris products. Selected citations for Bay 11-7821 include:

Jiang (2017) Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice. J Neuroinflammation 14 207 PMID: 29070054

Yu et al (2014) Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation. PLoS One 9 e112989 PMID: 25398056

Jia et al (2015) β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer. Cell Death Differ 22 298 PMID: 25257174

Yang et al (2011) Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexamethasone and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells. J Biol Chem 286 27988 PMID: 21705340


Do you know of a great paper that uses Bay 11-7821 from Tocris? If so please let us know.

Reviews for Bay 11-7821

There are currently no reviews for this product. Be the first to review Bay 11-7821 and earn rewards!

Have you used Bay 11-7821?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis