Bay 11-7821

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Description: E2 ubiquitin (Ub) conjugating enzymes inhibitor
Alternative Names: Bay 11-7082
Chemical Name: (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
Purity: ≥99% (HPLC)
Citations (8)

Biological Activity for Bay 11-7821

Bay 11-7821 is an E2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines. Also inhibits activation of NLRP3 inflammasome. Binds and inhibits gasdermin D (GSDMD) pore formation. Pyroptosis inhibitor.

Technical Data for Bay 11-7821

M. Wt 207.25
Formula C10H9NO2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 19542-67-7
PubChem ID 5353431
Smiles CC1=CC=C(C=C1)S(=O)(=O)\C=C\C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bay 11-7821

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 5.18 25
DMSO 20.73 100

Preparing Stock Solutions for Bay 11-7821

The following data is based on the product molecular weight 207.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.83 mL 24.13 mL 48.25 mL
5 mM 0.97 mL 4.83 mL 9.65 mL
10 mM 0.48 mL 2.41 mL 4.83 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

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References for Bay 11-7821

References are publications that support the biological activity of the product.

Mori et al (2002) Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 100 1828 PMID: 12176906

Pierce et al (1997) Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 272 21096 PMID: 9261113

Strickson et al (2013) The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem.J. 451 427 PMID: 23441730

Juliana et al (2010) Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J.Biol.Chem. 285 9792 PMID: 20093358

Pandeya et al (2019) Gasdermin D (GSDMD) as a new target for the treatment of infection. Medchemcomm 10 660 PMID: 31191857

If you know of a relevant reference for Bay 11-7821, please let us know.

View Related Products by Product Action

View all Ubiquitin/Ubl E2 Conjugating Enzyme Inhibitors

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8 Citations for Bay 11-7821

Citations are publications that use Tocris products. Selected citations for Bay 11-7821 include:

Clement et al (2014) CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells. Proc Natl Acad Sci U S A 111 E1101 PMID: 24616502

Han et al (2017) Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome. J Ginseng Res 41 513 PMID: 29021698

Yu et al (2014) Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation. PLoS One 9 e112989 PMID: 25398056

Jia et al (2015) β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer. Cell Death Differ 22 298 PMID: 25257174

Do you know of a great paper that uses Bay 11-7821 from Tocris? Please let us know.

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