Bay 11-7085

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Description: Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
Alternative Names: Bay 11-7083
Chemical Name: (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
Purity: ≥99% (HPLC)
Citations (6)
Pathways (1)

Biological Activity for Bay 11-7085

Bay 11-7085 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation (IC50 ~ 10 μM); leads to decreased NF-κB and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo.

Compound Libraries for Bay 11-7085

Bay 11-7085 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Bay 11-7085

M. Wt 249.33
Formula C13H15NO2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 196309-76-9
PubChem ID 5353432
Smiles CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)\C=C\C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bay 11-7085

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 24.93 100
DMSO 24.93 100

Preparing Stock Solutions for Bay 11-7085

The following data is based on the product molecular weight 249.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.01 mL 20.05 mL 40.11 mL
5 mM 0.8 mL 4.01 mL 8.02 mL
10 mM 0.4 mL 2.01 mL 4.01 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets for Bay 11-7085

Certificate of Analysis / Product Datasheet
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References for Bay 11-7085

References are publications that support the biological activity of the product.

Hu et al (2001) An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism. Cancer Res. 61 6290 PMID: 11507084

Pierce et al (1997) Novel inhibitors of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 272 21096 PMID: 9261113

Scaife et al (2002) Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer Res. 62 6870 PMID: 12460901

If you know of a relevant reference for Bay 11-7085, please let us know.

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View all NF-κB and IκB Inhibitors

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6 Citations for Bay 11-7085

Citations are publications that use Tocris products. Selected citations for Bay 11-7085 include:

Kwon et al (2014) Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells. Nat Commun 5 4416 PMID: 25048699

Kwon et al (2016) Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model. J Clin Invest 126 2626 PMID: 27294523

Liang et al (2017) Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders. J Allergy Clin Immunol 139 1217 PMID: 27884600

Clark et al (2015) Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases. PLoS One 10 e0120075 PMID: 25816133

Do you know of a great paper that uses Bay 11-7085 from Tocris? Please let us know.

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Pathways for Bay 11-7085

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.