Bay 11-7085

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Cat.No. 1743 - Bay 11-7085 | C13H15NO2S | CAS No. 196309-76-9
Description: Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
Alternative Names: Bay 11-7083
Chemical Name: (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature
Pathways

Biological Activity

Irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation (IC50 ~ 10 μM); leads to decreased NF-κB and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo.

Technical Data

M. Wt 249.33
Formula C13H15NO2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 196309-76-9
PubChem ID 5353432
InChI Key VHKZGNPOHPFPER-ONNFQVAWSA-N
Smiles CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)\C=C\C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.93 100
ethanol 24.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 249.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.01 mL 20.05 mL 40.11 mL
5 mM 0.8 mL 4.01 mL 8.02 mL
10 mM 0.4 mL 2.01 mL 4.01 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hu et al (2001) An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism. Cancer Res. 61 6290 PMID: 11507084

Pierce et al (1997) Novel inhibitors of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 272 21096 PMID: 9261113

Scaife et al (2002) Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer Res. 62 6870 PMID: 12460901


If you know of a relevant reference for Bay 11-7085, please let us know.

View Related Products by Product Action

View all NF-κB and IκB Inhibitors

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3 Citations for Bay 11-7085

Citations are publications that use Tocris products. Selected citations for Bay 11-7085 include:

Clark et al (2015) Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases. PLoS One 10 e0120075 PMID: 25816133

Przybyla et al (2013) Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3. Stem Cells 31 1097 PMID: 23404867

Hussain et al (2012) Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis. PLoS One 7 e39945 PMID: 22768179


Do you know of a great paper that uses Bay 11-7085 from Tocris? If so please let us know.

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Literature in this Area

Cancer

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  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
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Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Pathways for Bay 11-7085

NF-κB

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.

Protocols

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