IκB Kinase (IKK) is an enzyme complex that forms part of the NF-κB signaling pathway. The IKK complex is comprised of three subunits (IKKα (IKK1), IKKβ (IKK2) and IKKγ (NEMO)), the α- and β-subunits are catalytically active whereas the γ-subunit has a regulatory function.
|Product Name / Activity
|Selective IKKα and IKKβ inhibitor
|Inhibitor of TBK1 and IKKε; antiallergic agent
|Selective allosteric inhibitor of IKK; anti-inflammatory
|Potent and selective IKKε inhibitor
|Selective inhibitor of IKK
|Inhibitor of IKKβ; also exhibits antibacterial activity
|ML 120B dihydrochloride
|Novel IKK2-selective inhibitor
|Potent and selective IKKβ inhibitor
|PS 1145 dihydrochloride
|Selective IKK inhibitor; orally active
|IKKβ inhibitor; attenuates NF-κB-induced gene expression
|Potent, selective inhibitor of IKKβ
IκB Kinase (IKK) is an enzyme complex that forms part of the NF-κB signaling pathway. The complex is comprised of three subunits (IKKα (IKK1), IKKβ (IKK2) and IKKγ (NEMO)), the α- and β-subunits are catalytically active whereas the γ-subunit serves a regulatory function.
Activation of NF-κB occurs via degradation of IκB, a process that is initiated by its phosphorylation by IκB kinase (IKK). Phosphorylated IκB becomes dissociated from NF-κB, unmasking the nuclear localization signal (NLS). Phosphorylation also results in IκB ubiquitination and targeting to the proteasome. NF-κB can now enter the nucleus and regulate gene expression.
External sources of pharmacological information for IκB Kinase :
IκB Kinase Gene Data
|Gene Accession No.
|Protein Accession No.