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IκB Kinase

IκB Kinase (IKK) is an enzyme complex that forms part of the NF-κB signaling pathway. The IKK complex is comprised of three subunits (IKKα (IKK1), IKKβ (IKK2) and IKKγ (NEMO)), the α- and β-subunits are catalytically active whereas the γ-subunit has a regulatory function.

Products
Background
Gene Data

IκB Kinase Inhibitors
Cat. No. Product Name / Activity
4547 ACHP
Selective IKKα and IKKβ inhibitor
4857 Amlexanox
Inhibitor of TBK1 and IKKε; antiallergic agent
4806 BMS 345541
Selective allosteric inhibitor of IKK; anti-inflammatory
5672 GSK 319347A
Potent and selective IKKε inhibitor
2539 IKK 16
Selective inhibitor of IKK
2611 IMD 0354
Inhibitor of IKKβ; also exhibits antibacterial activity
4899 ML 120B dihydrochloride
Novel IKK2-selective inhibitor
4238 PF 184
Potent and selective IKKβ inhibitor
2559 TPCA-1
Potent, selective inhibitor of IKKβ

Related Targets

    IκB Kinase (IKK) is an enzyme complex that forms part of the NF-κB signaling pathway. The complex is comprised of three subunits (IKKα (IKK1), IKKβ (IKK2) and IKKγ (NEMO)), the α- and β-subunits are catalytically active whereas the γ-subunit serves a regulatory function.

    Activation of NF-κB occurs via degradation of IκB, a process that is initiated by its phosphorylation by IκB kinase (IKK). Phosphorylated IκB becomes dissociated from NF-κB, unmasking the nuclear localization signal (NLS). Phosphorylation also results in IκB ubiquitination and targeting to the proteasome. NF-κB can now enter the nucleus and regulate gene expression.

    External sources of pharmacological information for IκB Kinase :

      IκB Kinase Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      IKKα Human CHUK NM_001278 O15111
      Mouse Chuk NM_007700 NM_007700
      IKKβ Human IKBKB NM_001556 O14920
      Mouse Ikbkb NM_010546 O88351
      Rat Ikbkb NM_053355 Q9QY78
      IKKγ Human IKBKG NM_003639 Q9Y6K9
      Mouse Ikbkg NM_178590 O88522