IκB Kinase

IκB Kinase (IKK) is an enzyme complex that forms part of the NF-κB signaling pathway. The IKK complex is comprised of three subunits (IKKα (IKK1), IKKβ (IKK2) and IKKγ (NEMO)), the α- and β-subunits are catalytically active whereas the γ-subunit has a regulatory function.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
4547 ACHP
Selective IKKα and IKKβ inhibitor
4857 Amlexanox
Inhibitor of TBK1 and IKKε; antiallergic agent
5300 BI 605906
Selective IKKβ inhibitor
4806 BMS 345541
Selective allosteric inhibitor of IKK; anti-inflammatory
5672 GSK 319347A
Potent and selective IKKε inhibitor
2539 IKK 16
Selective inhibitor of IKK
2611 IMD 0354
Inhibitor of IKKβ
4899 ML 120B dihydrochloride
Novel IKK2-selective inhibitor
4238 PF 184
Potent and selective IKKβ inhibitor
4569 PS 1145 dihydrochloride
Selective IKK inhibitor; orally active
3318 SC 514
IKKβ inhibitor; attenuates NF-κB-induced gene expression
2559 TPCA-1
Potent, selective inhibitor of IKKβ

Related Targets

    IκB Kinase (IKK) is an enzyme complex that forms part of the NF-κB signaling pathway. The complex is comprised of three subunits (IKKα (IKK1), IKKβ (IKK2) and IKKγ (NEMO)), the α- and β-subunits are catalytically active whereas the γ-subunit serves a regulatory function.

    Activation of NF-κB occurs via degradation of IκB, a process that is initiated by its phosphorylation by IκB kinase (IKK). Phosphorylated IκB becomes dissociated from NF-κB, unmasking the nuclear localization signal (NLS). Phosphorylation also results in IκB ubiquitination and targeting to the proteasome. NF-κB can now enter the nucleus and regulate gene expression.

    Literature for IκB Kinase

    Tocris offers the following scientific literature for IκB Kinase to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


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    Kinases Product Listing

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    IκB Kinase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    IKKα Human CHUK NM_001278 O15111
    Mouse Chuk NM_007700 NM_007700
    IKKβ Human IKBKB NM_001556 O14920
    Mouse Ikbkb NM_010546 O88351
    Rat Ikbkb NM_053355 Q9QY78
    IKKγ Human IKBKG NM_003639 Q9Y6K9
    Mouse Ikbkg NM_178590 O88522