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IκB Kinase (IKK) is an enzyme complex that forms part of the NF-κB signaling pathway. The IKK complex is comprised of three subunits (IKKα (IKK1), IKKβ (IKK2) and IKKγ (NEMO)), the α- and β-subunits are catalytically active whereas the γ-subunit has a regulatory function.
|Cat. No.||Product Name / Activity|
|Selective IKKα and IKKβ inhibitor|
|Inhibitor of TBK1 and IKKε; antiallergic agent|
|Selective IKKβ inhibitor|
|Selective allosteric inhibitor of IKK; anti-inflammatory|
|IKKβ inhibitor; inhibits NF-κB pathway; also Nrf2 pathway activator|
|Potent and selective IKKε inhibitor|
|Selective inhibitor of IKK|
|Inhibitor of IKKβ; also exhibits antibacterial activity|
|4899||ML 120B dihydrochloride|
|Novel IKK2-selective inhibitor|
|Potent and selective IKKβ inhibitor|
|4569||PS 1145 dihydrochloride|
|Selective IKK inhibitor; orally active|
|IKKβ inhibitor; attenuates NF-κB-induced gene expression|
|Potent, selective inhibitor of IKKβ|
IκB Kinase (IKK) is an enzyme complex that forms part of the NF-κB signaling pathway. The complex is comprised of three subunits (IKKα (IKK1), IKKβ (IKK2) and IKKγ (NEMO)), the α- and β-subunits are catalytically active whereas the γ-subunit serves a regulatory function.
Activation of NF-κB occurs via degradation of IκB, a process that is initiated by its phosphorylation by IκB kinase (IKK). Phosphorylated IκB becomes dissociated from NF-κB, unmasking the nuclear localization signal (NLS). Phosphorylation also results in IκB ubiquitination and targeting to the proteasome. NF-κB can now enter the nucleus and regulate gene expression.
Tocris offers the following scientific literature for IκB Kinase to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|