Glucagon-Like Peptide 1 Receptors

Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally and peripherally. GLP-1 receptors mediate the effects of the incretin axis.

Products
Background
Literature (3)
Gene Data

Glucagon-Like Peptide 1 Receptor Agonists

Cat. No. Product Name / Activity
1933 Exendin-4
Potent GLP-1 receptor agonist
5374 GLP-1 (7-37)
Endogenous bioactive GLP-1 receptor ligand
1851 Glucagon-like peptide 1 (1-37) (human, rat)
Endogenous pancreatic peptide
2082 Glucagon-like peptide 1 (7-36) amide (human, rat)
Potent insulinotropic peptide
6517 Liraglutide
Highly potent, long-acting GLP-1 receptor agonist
2094 Oxyntomodulin (porcine, bovine)
GLP-1 receptor agonist; endogenous preproglucagon derived peptide; modulates feeding and metabolism

Glucagon-Like Peptide 1 Receptor Antagonists

Cat. No. Product Name / Activity
2081 Exendin-3 (9-39) amide
Potent GLP-1 receptor antagonist
3266 GLP-1 (9-36) amide
Metabolite of GLP-1-(7-36) (Cat. No. 2082)
6355 VU 0650991
Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant

Glucagon-Like Peptide 1 Receptor Modulators

Cat. No. Product Name / Activity
4778 BETP
Positive allosteric modulator of GLP-1 receptors
6807 NNC 0640
Negative allosteric modulator of glucagon and GLP-1 receptors

Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally (hypothalamus and brainstem) and peripherally (pancreatic islet cells, stomach and heart).

GLP-1 receptors mediate the effects of the incretin axis; the functional connection between the intestine and the islets of Langerhans in the pancreas. Activation stimulates insulin release from the islet β-cells in a glucose-dependent manner and suppresses glucagon secretion from islet α-cells. In addition, GLP-1 receptors delay gastric emptying and regulate appetite. The human GLP-1 receptor gene is localized on chromosome 6p21.

External sources of pharmacological information for Glucagon-Like Peptide 1 Receptors :

Literature for Glucagon-Like Peptide 1 Receptors

Tocris offers the following scientific literature for Glucagon-Like Peptide 1 Receptors to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Glucagon-Like Peptide 1 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human GLP1R NM_002062 P43220
Mouse Glp1r NM_021332 O35659
Rat Glp1r NM_012728 P32301