Glucagon-Like Peptide 1 Receptors
Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally and peripherally. GLP-1 receptors mediate the effects of the incretin axis.
Glucagon-Like Peptide 1 Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1933 | Exendin-4 |
| Potent GLP-1 receptor agonist | |
| 5374 | GLP-1 (7-37) |
| Endogenous bioactive GLP-1 receptor ligand | |
| 1851 | Glucagon-like peptide 1 (1-37) (human, rat) |
| Endogenous pancreatic peptide | |
| 2082 | Glucagon-like peptide 1 (7-36) amide (human, rat) |
| Potent insulinotropic peptide | |
| 6517 | Liraglutide |
| Highly potent, long-acting GLP-1 receptor agonist | |
| 2094 | Oxyntomodulin (porcine, bovine) |
| GLP-1 receptor agonist; endogenous preproglucagon derived peptide; modulates feeding and metabolism | |
Glucagon-Like Peptide 1 Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 2081 | Exendin-3 (9-39) amide |
| Potent GLP-1 receptor antagonist | |
| 3266 | GLP-1 (9-36) amide |
| Metabolite of GLP-1-(7-36) (Cat. No. 2082) | |
| 6355 | VU 0650991 |
| Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant | |
Glucagon-Like Peptide 1 Receptor Modulators |
|
| Cat. No. | Product Name / Activity |
| 4778 | BETP |
| Positive allosteric modulator of GLP-1 receptors | |
| 6807 | NNC 0640 |
| Negative allosteric modulator of glucagon and GLP-1 receptors | |
Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally (hypothalamus and brainstem) and peripherally (pancreatic islet cells, stomach and heart).
GLP-1 receptors mediate the effects of the incretin axis; the functional connection between the intestine and the islets of Langerhans in the pancreas. Activation stimulates insulin release from the islet β-cells in a glucose-dependent manner and suppresses glucagon secretion from islet α-cells. In addition, GLP-1 receptors delay gastric emptying and regulate appetite. The human GLP-1 receptor gene is localized on chromosome 6p21.
External sources of pharmacological information for Glucagon-Like Peptide 1 Receptors :
Literature for Glucagon-Like Peptide 1 Receptors
Tocris offers the following scientific literature for Glucagon-Like Peptide 1 Receptors to showcase our products. We invite you to request* your copy today!
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GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
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Peptide Hormone Receptors Product Listing
A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Our Peptide Hormone Receptors Listing highlights over 200 products for peptide hormone receptors.
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Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis.
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