Glucagon-Like Peptide 1 Receptors

Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally and peripherally. GLP-1 receptors mediate the effects of the incretin axis.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1933 Exendin-4
Potent GLP-1 receptor agonist
5374 GLP-1 (7-37)
Endogenous bioactive GLP-1 receptor ligand
1851 Glucagon-like peptide 1 (1-37) (human, rat)
Endogenous pancreatic peptide
2082 Glucagon-like peptide 1 (7-36) amide (human, rat)
Potent insulinotropic peptide

Antagonists

Cat No Product Name / Activity
2081 Exendin-3 (9-39) amide
Potent GLP-1 receptor antagonist
3266 GLP-1 (9-36) amide
Metabolite of GLP-1-(7-36) (Cat. No. 2082)

Modulators

Cat No Product Name / Activity
4778 BETP
Positive allosteric modulator of GLP-1 receptors

Other

Cat No Product Name / Activity
2094 Oxyntomodulin (porcine, bovine)
Endogenous gut peptide; modulates feeding and metabolism

Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally (hypothalamus and brainstem) and peripherally (pancreatic islet cells, stomach and heart).

GLP-1 receptors mediate the effects of the incretin axis; the functional connection between the intestine and the islets of Langerhans in the pancreas. Activation stimulates insulin release from the islet β-cells in a glucose-dependent manner and suppresses glucagon secretion from islet α-cells. In addition, GLP-1 receptors delay gastric emptying and regulate appetite. The human GLP-1 receptor gene is localized on chromosome 6p21.

External sources of pharmacological information for Glucagon-Like Peptide 1 Receptors :

Literature for Glucagon-Like Peptide 1 Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Glucagon-Like Peptide 1 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human GLP1R NM_002062 P43220
Mouse Glp1r NM_021332 O35659
Rat Glp1r NM_012728 P32301