Glucagon-Like Peptide 1 Receptors
Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally and peripherally. GLP-1 receptors mediate the effects of the incretin axis.
Glucagon-Like Peptide 1 Receptor Agonists |
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|---|---|
| Cat. No. | Product Name / Activity |
| 8874 | DMB New |
| GLP-1R agonist, also GSDMD (Gasdermin D) agonist, activator of pyroptosis | |
| 1933 | Exendin-4 |
| Potent GLP-1 receptor agonist | |
| 5374 | GLP-1 (7-37) |
| Endogenous bioactive GLP-1 receptor ligand | |
| 1851 | Glucagon-like peptide 1 (1-37) (human, rat) |
| Endogenous pancreatic peptide | |
| 2082 | Glucagon-like peptide 1 (7-36) amide (human, rat) |
| Potent insulinotropic peptide | |
| 6517 | Liraglutide |
| Highly potent, long-acting GLP-1 receptor agonist | |
Glucagon-Like Peptide 1 Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 2081 | Exendin-3 (9-39) amide |
| Potent GLP-1 receptor antagonist | |
| 3266 | GLP-1 (9-36) amide |
| Metabolite of GLP-1-(7-36) (Cat. No. 2082) | |
| 6355 | VU 0650991 |
| Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant | |
Glucagon-Like Peptide 1 Receptor Modulators |
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| Cat. No. | Product Name / Activity |
| 4778 | BETP |
| Positive allosteric modulator of GLP-1 receptors | |
| 7959 | LSN 3318839 |
| Glucagon-like peptide-1 receptor (GLP1-R) positive allosteric modulator | |
| 6807 | NNC 0640 |
| Negative allosteric modulator of glucagon and GLP-1 receptors | |
Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally (hypothalamus and brainstem) and peripherally (pancreatic islet cells, stomach and heart).
GLP-1 receptors mediate the effects of the incretin axis; the functional connection between the intestine and the islets of Langerhans in the pancreas. Activation stimulates insulin release from the islet β-cells in a glucose-dependent manner and suppresses glucagon secretion from islet α-cells. In addition, GLP-1 receptors delay gastric emptying and regulate appetite. The human GLP-1 receptor gene is localized on chromosome 6p21.
External sources of pharmacological information for Glucagon-Like Peptide 1 Receptors :
Literature for Glucagon-Like Peptide 1 Receptors
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis.
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