BETP

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Cat.No. 4778 - BETP | C20H17F3N2O2S | CAS No. 1371569-69-5
Description: Positive allosteric modulator of GLP-1 receptors
Chemical Name: 2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)pyrimidine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor. Increases binding affinity of oxyntomodulin for the GLP-1 receptor. Potentiates oxyntomodulin-mediated GLP-1 receptor signaling in vitro and insulin secretion in vivo. Has no effect on GLP-2, GIP, PTH or glucagon receptors.

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Technical Data

M. Wt 406.42
Formula C20H17F3N2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1371569-69-5
PubChem ID 49868481
InChI Key NTDFYGSSDDMNHI-UHFFFAOYSA-N
Smiles CCS(C1=NC(C2=CC=CC(OCC3=CC=CC=C3)=C2)=CC(C(F)(F)F)=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 20.32 50
DMSO 40.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 406.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.3 mL 24.61 mL
5 mM 0.49 mL 2.46 mL 4.92 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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References

References are publications that support the biological activity of the product.

Willard et al (2012) Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin. Mol.Pharmacol. 82 1066 PMID: 22930710

Sloop et al (2010) Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets. Diabetes 59 3099 PMID: 20823098

Cheong et al (2012) Two small molecule agonists of glucagon-like peptide-1 receptor modulate the receptor activation response differently. Biochem.Biophys.Res.Comm. 417 558 PMID: 22177947


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Keywords: BETP, BETP supplier, Allosteric, modulators, GLP-1, GLP1, receptors, glucagon-like, peptide, agonists, Glucagon-Like, Peptide, 1, Receptors, 4778, Tocris Bioscience

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