Glucagon Receptors

The glucagon receptor is a member of the glucagon receptor family that also includes GLP-1, GLP-2, secretin, GHRH and GIP receptors. The glucagon receptor regulates blood glucose levels and is predominantly expressed in the pancreas, liver and kidneys.

Products
Background
Literature
Gene Data

Antagonists

Cat No Product Name / Activity
2216 des-His1-[Glu9]-Glucagon (1-29) amide
Glucagon receptor antagonist
2311 L-168,049
Potent, orally active human glucagon receptor antagonist

Other

Cat No Product Name / Activity
2094 Oxyntomodulin (porcine, bovine)
Endogenous gut peptide; modulates feeding and metabolism

The glucagon receptor is a member of the glucagon receptor family that also includes GLP-1, GLP-2, secretin, GHRH and GIP receptors. The glucagon receptor regulates blood glucose levels via control of hepatic glycogenolysis and gluconeogenesis, and via regulation of insulin release from the β-cells of pancreatic islets.

The glucagon receptor is predominantly expressed in the pancreas, liver and kidneys, but is also found to a lesser extent in the heart, adipose tissue, spleen, thymus and adrenal glands. The human glucagon receptor gene is localized on chromosome 17q25.

External sources of pharmacological information for Glucagon Receptors :

Literature for Glucagon Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Glucagon Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human GCGR NM_000160 P47871
Mouse Gcgr NM_008101 Q61606
Rat Gcgr NM_172091 P30082