Glucagon Receptors

The glucagon receptor is a member of the glucagon receptor family that also includes GLP-1, GLP-2, secretin, GHRH and GIP receptors. The glucagon receptor regulates blood glucose levels and is predominantly expressed in the pancreas, liver and kidneys.

Products
Background
Gene Data

Antagonists

Cat No Product Name / Activity
2216 des-His1-[Glu9]-Glucagon (1-29) amide
Glucagon receptor antagonist
2311 L-168,049
Potent, orally active human glucagon receptor antagonist

Other

Cat No Product Name / Activity
2094 Oxyntomodulin (porcine, bovine)
Endogenous gut peptide; modulates feeding and metabolism

The glucagon receptor is a member of the glucagon receptor family that also includes GLP-1, GLP-2, secretin, GHRH and GIP receptors. The glucagon receptor regulates blood glucose levels via control of hepatic glycogenolysis and gluconeogenesis, and via regulation of insulin release from the β-cells of pancreatic islets.

The glucagon receptor is predominantly expressed in the pancreas, liver and kidneys, but is also found to a lesser extent in the heart, adipose tissue, spleen, thymus and adrenal glands. The human glucagon receptor gene is localized on chromosome 17q25.

External sources of pharmacological information for Glucagon Receptors :

Glucagon Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human GCGR NM_000160 P47871
Mouse Gcgr NM_008101 Q61606
Rat Gcgr NM_172091 P30082