Secretin Receptors

Secretin receptors are members of the glucagon receptor family that also includes glucagon, GLP-1, GLP-2, GHRH and GIP receptors. Secretin receptors are classically localized to the epithelial cells within the pancreatic and biliary ducts, where they bind to the hormone secretin.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1918 Secretin (human)
Gastrointestinal peptide
1919 Secretin (rat)
Gastrointestinal peptide

Secretin receptors are members of the glucagon receptor family that also includes glucagon, GLP-1, GLP-2, GHRH and GIP receptors. Secretin receptors are classically localized to the epithelial cells within the pancreatic and biliary ducts, where they stimulate the release of alkaline bicarbonate-rich fluid to neutralize acidic chyme from the stomach. This protects the duodenal mucosa and provides an optimal intraluminal environment for digestion to take place.

Secretin receptors are also found in the CNS, where they are thought to play a role in the regulation of the hypothalamic-pituitary-axis (HPA) axis. The human secretin receptor gene is localized on chromosome 2p14.1.

External sources of pharmacological information for Secretin Receptors :

Literature for Secretin Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Secretin Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human SCTR NM_002980 P47872
Mouse Sctr NM_001012322 Q5FWI2
Rat Sctr NM_031115 P23811