GLP-1 (9-36) amide

Pricing Availability   Qty
Description: Metabolite of GLP-1-(7-36) (Cat. No. 2082)
Alternative Names: Glucagon-like peptide 1 (9-36) amide
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for GLP-1 (9-36) amide

GLP-1 (9-36) amide is a N-terminal truncated metabolite of glucagon-like peptide GLP-1-(7-36) (Cat. No. 2082) formed by dipeptidyl peptidase-IV cleavage. Acts as an antagonist at the human GLP-1 receptor. Inhibits hepatic glucose production in vivo and is a weak insulinotropic agent.

Technical Data for GLP-1 (9-36) amide

M. Wt 3089.44
Formula C140H214N36O43

(Modification: Arg-28 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 161748-29-4
PubChem ID 90488821
Smiles [H]N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GLP-1 (9-36) amide

Solubility Soluble to 2 mg/ml in 0.025% acetic acid

Product Datasheets for GLP-1 (9-36) amide

Certificate of Analysis / Product Datasheet
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References for GLP-1 (9-36) amide

References are publications that support the biological activity of the product.

Knudsen and Pridal (1996) Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur.J.Pharmacol. 318 429 PMID: 9016935

Elahi et al (2008) GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide is a glucoregulatory peptide. Obesity 16 1501 PMID: 18421270

Deacon et al (1995) Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J.Clin.Endocrinol.Met. 80 952

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Citations for GLP-1 (9-36) amide

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.