GIP Receptor

The GIP (gastric inhibitory polypeptide or glucose-dependent insulinotropic peptide) receptor is a member of the glucagon receptor family that also includes glucagon, GLP-1, GLP-2, secretin and GHRH receptors. The GIP receptor is involved in glucose homeostasis.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
2257 GIP (1-39)
Highly potent insulinotropic peptide
2084 GIP (human)
Potent insulinotropic gut hormone
5837 [Pro3]-GIP (Rat)
High affinity rat GIP receptor partial agonist

Antagonists

Cat No Product Name / Activity
5838 [Pro3]-GIP (Mouse)
GIP receptor antagonist

The GIP (gastric inhibitory polypeptide or glucose-dependent insulinotropic peptide) receptor is a member of the glucagon receptor family that also includes glucagon, GLP-1, GLP-2, secretin and GHRH receptors. The GIP receptor is involved in glucose homeostasis via potentiation of glucose-dependent insulin secretion from the pancreatic islet β-cells. It also inhibits gastric acid secretion. The tissue distribution of this receptor is broad, with high levels of expression in the islet β-cells. The human GIP receptor gene is localized on chromosome 19q13.3.

External sources of pharmacological information for GIP Receptor :

Literature for GIP Receptor

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

GIP Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human GIPR NM_000164 P48546
Mouse Gipr NM_001080815 Q0P543
Rat Gipr NM_012714 P43219