Dipeptidyl Peptidase IV

Dipeptidyl Peptidase IV (DPP-IV) (also known as CD26) is a ubiquitous, membrane-bound enzyme that has several roles including in nutrition, metabolism, bone marrow mobilization, cancer growth, cell adhesion and within both the immune and endocrine systems.

Gene Data

Dipeptidyl Peptidase IV Inhibitors

Cat. No. Product Name / Activity
6019 Diprotin A
Dipeptidyl peptidase IV (DPP-IV) inhibitor
2783 DPPI 1c hydrochloride
Dipeptidyl peptidase IV (DPP-IV) inhibitor
6507 Saxagliptin hydrochloride
High affinity DPP-IV inhibitor; active in vivo
6816 Sitagliptin phosphate
Potent and selective DPP IV inhibitor
3719 Talabostat mesylate
Potent DPP IV inhibitor; activates NLRP1b inflammasome

Dipeptidyl Peptidase IV (DPP-IV) (also known as CD26) is a ubiquitous, membrane-bound enzyme that has roles in nutrition, metabolism, the immune and endocrine systems, bone marrow mobilization, cancer growth and cell adhesion.

DDP-IV catalyzes the hydrolysis of N-terminal dipeptides from polypeptides with proline or alanine in the penultimate position. This enzyme has many natural substrates including GLP-1, GIP, PACAP 38, NPY and GRP. DPP-IV exists as a homodimer and each monomer consists of two domains; an α/β hydrolase domain and an eight-blade β-propeller domain. DDP-IV binds to, but does not cleave, adenosine deaminase, kidney Na+/H+ ion exchanger and fibronectin, which localizes these molecules to the cell surface. A soluble form of DDP-IV does also exist, although it is only known to function in relation to T-cell proliferation. The human gene encoding DPP-IV is localized to chromosome 2q24.2.

External sources of pharmacological information for Dipeptidyl Peptidase IV :

    Dipeptidyl Peptidase IV Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human DPP4 NM_001935 P27487
    Mouse Dpp4 NM_010074 P28843
    Rat Dpp4 NM_012789 P14740