Dipeptidyl Peptidase IV

Dipeptidyl Peptidase IV (DPP-IV) (also known as CD26) is a ubiquitous, membrane-bound enzyme that has several roles including in nutrition, metabolism, bone marrow mobilization, cancer growth, cell adhesion and within both the immune and endocrine systems.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
6019 Diprotin A
Dipeptidyl peptidase IV (DPP-IV) inhibitor
2783 DPPI 1c hydrochloride
Dipeptidyl peptidase IV (DPP-IV) inhibitor
2790 K 579
Dipeptidyl peptidase IV (DPP-IV) inhibitor
3506 NVP DPP 728 dihydrochloride
Potent, orally active dipeptidyl peptidase IV (DPP-IV) inhibitor
4145 PK 44 phosphate
Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor

Dipeptidyl Peptidase IV (DPP-IV) (also known as CD26) is a ubiquitous, membrane-bound enzyme that has roles in nutrition, metabolism, the immune and endocrine systems, bone marrow mobilization, cancer growth and cell adhesion.

DDP-IV catalyzes the hydrolysis of N-terminal dipeptides from polypeptides with proline or alanine in the penultimate position. This enzyme has many natural substrates including GLP-1, GIP, PACAP 38, NPY and GRP. DPP-IV exists as a homodimer and each monomer consists of two domains; an α/β hydrolase domain and an eight-blade β-propeller domain. DDP-IV binds to, but does not cleave, adenosine deaminase, kidney Na+/H+ ion exchanger and fibronectin, which localizes these molecules to the cell surface. A soluble form of DDP-IV does also exist, although it is only known to function in relation to T-cell proliferation. The human gene encoding DPP-IV is localized to chromosome 2q24.2.

Literature for Dipeptidyl Peptidase IV

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New Product Guide (Spring/Summer 2017)

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  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Dipeptidyl Peptidase IV Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human DPP4 NM_001935 P27487
Mouse Dpp4 NM_010074 P28843
Rat Dpp4 NM_012789 P14740