Glucagon-like peptide 1 (1-37) (human, rat)

Pricing Availability Delivery Time Qty
Cat.No. 1851 - Glucagon-like peptide 1 (1-37) (human, rat) | His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly | CAS No. 87805-34-3
Description: Endogenous pancreatic peptide
Alternative Names: GLP-1 (1-37) amide
Datasheet
Citations (1)
Literature

Biological Activity

Pancreatic hormone synthesized by post-translational processing of proglucagon. Unlike truncated forms of GLP-1, it has no effect on food intake in rats and does not enhance pancreatic insulin secretion. However it induces insulin expression in intestinal epithelial cells, which can restore glucose homeostasis when implanted into diabetic mice.

Technical Data

M. Wt 4169.52
Formula C186H275N51O59
Sequence HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
Storage Desiccate at -20°C
CAS Number 87805-34-3
PubChem ID 16131070
InChI Key UKVFVQPAANCXIL-FJVFSOETSA-N
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 5 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 4169.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.24 mL 1.2 mL 2.4 mL
5 mM 0.05 mL 0.24 mL 0.48 mL
10 mM 0.02 mL 0.12 mL 0.24 mL
50 mM 0 mL 0.02 mL 0.05 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bell et al (1983) Exon duplication and divergence in the human preproglucagon gene. Nature 304 368 PMID: 6877358

Navarro et al (1996) Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake. J.Neurochem. 67 1982 PMID: 8863504

Suzuki et al (2003) Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells. Proc.Natl.Acad.Sci.USA 100 5034 PMID:


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Keywords: Endogenous pancreatic peptide GLP1 Receptors Glucagon-Like Peptide 1 Glucagon-like peptide1 (1-37) (human rat) GLP1(1-37) amide diabetes GLP-1 (1-37) amide Glucagon-Like Peptide 1 Receptors

1 Citation for Glucagon-like peptide 1 (1-37) (human, rat)

Citations are publications that use Tocris products. Selected citations for Glucagon-like peptide 1 (1-37) (human, rat) include:

Zhang et al (2013) The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval. J Neurosci 33 5006 PMID: 23486971


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